CAUSES OF THROMBOCYTOPENIA IN A TERTIARY CARE CENTRE IN UTTAR PRADESH, INDIA: A RETROSPECTIVE STUDY OF 1050 PATIENTS

Abstract

**Background:** Thrombocytopenia is a common hematological disorder with diverse causes, ranging from infections to hematological malignancies and drug reactions.

**Aims:** To analyze the causes, severity, and demographic distribution of thrombocytopenia in patients attending a tertiary care centre in Uttar Pradesh, India.

**Materials and Methods:** A retrospective study of 1050 patients with thrombocytopenia between September 2024 and August 2025 was conducted. Clinical records, laboratory investigations, and etiological diagnoses were reviewed. Thrombocytopenia was categorized as mild (100,000–150,000/μL), moderate (50,000–99,999/μL), and severe (<50,000/μL). Data were analyzed descriptively, and results were represented using tables and figures.
**Results:** Infectious causes were most common (54.3%), with dengue (31.6%) and malaria (12.8%) predominating. Non-infectious causes included drug-induced thrombocytopenia (10.9%), aplastic anemia (8.3%), and chronic liver disease (7.4%). Severe thrombocytopenia was observed in 27.6% of patients. The majority were males (58%) and aged 21–40 years (44%).
**Conclusion:** Infectious etiologies, particularly dengue and malaria, remain the leading causes of thrombocytopenia in this region. Early identification and targeted management are essential to reduce morbidity.