AVERAGE AMOUNT OF ALCOHOL INTAKE IN PATIENTS ADMITTED WITH ALCOHOLIC HEPATITIS IN INDIA: A RETROSPECTIVE STUDY
Main Article Content
Keywords
Abstract
Background: Alcoholic hepatitis (AH) is a severe inflammatory liver disease caused by prolonged excessive alcohol consumption. Quantifying ethanol intake is essential for understanding its clinical spectrum and guiding preventive strategies.
Objectives: To determine the average daily alcohol intake (in grams of ethanol) among patients admitted with alcoholic hepatitis in a tertiary-care hospital in India.
Methods: A retrospective observational study was conducted over one year in the Department of Medicine. Seventy-nine patients diagnosed with alcoholic hepatitis between October 2024 and September 2025 were included. Data on quantity and type of alcohol consumed were retrieved from hospital records and converted to grams of ethanol using the formula: g ethanol = volume (ml) × ABV (%) × 0.8.
Results: Of the 79 patients (72 males, 7 females; mean age 46 ± 9 years), the mean daily ethanol intake was 118 ± 52 g/day; median 110 g (IQR 80–150 g). Eighty-five percent consumed >80 g/day. Spirits (68%) were the predominant beverage, followed by country liquor (22%) and beer (10%). Mean duration of alcohol use was 11.3 ± 4.8 years.
Conclusion: Patients admitted with alcoholic hepatitis had very high ethanol consumption, exceeding recognized hepatotoxic thresholds. Early screening and community-level interventions are needed to reduce the burden of alcohol-related liver disease.
References
2. Louvet A, Mathurin P. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol. 2015;12(4):231-242.
3. O’Shea RS et al. Alcoholic liver disease. Hepatology. 2010;51(1):307-328.
4. EASL Clinical Practice Guidelines. J Hepatol. 2018;69(1):154-181.
5. Murthy P et al. Alcohol consumption in India – an epidemiological review. Indian J Med Res. 2010;132:663-671.
6. NFHS-5, Ministry of Health and Family Welfare, Government of India; 2022.
7. Prasad R. Alcohol use on the rise in India. Lancet. 2009;373:17-18.
8. Addolorato G et al. Alcoholic liver disease: new perspectives in clinical management. Eur Rev Med Pharmacol Sci. 2020;24(10):5181-5190.
9. Singh SP et al. Clinical profile of alcoholic hepatitis in India. Trop Gastroenterol. 2016;37(2):104-109.
10. Khemichian S, Shah VH. Pathogenesis of alcoholic liver disease. Clin Liver Dis. 2019;23(1):71-84.
11. Seth D et al. Alcohol, liver disease and genetics. Clin Liver Dis. 2015;19(1):161-172.
12. Mathurin P et al. Corticosteroids improve short-term survival in alcoholic hepatitis. Hepatology. 2011;53(6):2183-2190.
13. Seitz HK, Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with alcohol use. Dig Dis. 2010;28(4-5):596-602.
14. WHO Global status report on alcohol and health, 2018.
15. Sharma A et al. Alcoholic liver disease in India: epidemiology and clinical patterns. J Clin Exp Hepatol. 2020;10(2):125-132.
16. Zakhari S. Overview: how is alcohol metabolized by the body? Alcohol Res Health. 2006;29(4):245-254.
