Effect of Photo-Bio modulation on lipid profile in Patients with type 2 diabetes mellitus: A Randomized Clinical Trial
Main Article Content
Keywords
laser watch, low level Laser therapy, Type 2 diabetes mellitus (T2DM), Lipid profile. .
Abstract
Objective: to investigate the low level laser therapy (LLLT) efficiency by using laser watch as an adjunctive therapy of dyslipidemia in type 2 diabetes mellitus (T2DM) patients.
Methods: The study included sixty adult patients with diabetic dyslipidemia of both gender. They were split into two groups. Study group received anti diabetic drugs along with laser watch therapy (3 sessions /week for 12 weeks), while control group received only anti diabetic drugs. Blood sugar (FBS, 2HPP and HbA1C) and lipid panel (TG, TC, LDL and HDL) were measured before and at completion of the study.
Results: A significant improvement in blood sugar and serum lipid profile was seen in both groups (P < 0.001), the study group, however, displayed more significant outcomes (P < 0.001).
Conclusion: LLLT using laser watch can be used as a complementary treatment for dyslipidemia in T2DM patients to improve blood lipid profile and blood sugar
References
1. American Diabetes Association. Introduction: Standards of medical care in diabetes – 2018. Diabetes Care. 2018; 41(Suppl. 1):S1–S2; doi:10.2337/dc18-Sint01
2. IDF Diabetes Atlas 2019: Worldwide toll of diabetes. [Jun; 2020]; http://www.diabetesatlas.org/en/sections/worldw ide-toll-of-diabetes.html 2020. Federation I. D.(2019). IDF diabetes atlas ninth. Dunia: IDF.
3. Baynest HW. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J Diabetes Metab. 2015; 6(5):1000541; doi:10.4172/2155-6156.1000541.
4. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011 Dec; 94(3): 311-21. doi: 10.1016/j.diabres.2011.10.029. Epub 2011 Nov
12. PMID: 22079683.5. Jialal I, Singh G. Management of diabetic dyslipidemia: An update. World J Diabetes. 2019 May 15; 10(5):280-290. doi:10.4239/wjd.v10.i5.280. PMID: 31139315; PMCID: PMC6522756.
6. Mithal A, Majhi D, Shunmugavelu M, Talwarkar PG, Vasnawala H, Raza AS. Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID). Indian J Endocrinol Metab. 2014 Sep; 18(5): 642-7. doi: 10.4103/2230-8210.139220. PMID: 25285280;
PMCID: PMC4171886.
7. Qi L, Ding X, Tang W, Li Q, Mao D, Wang Y. Prevalence and Risk Factors Associated with Dyslipidemia in Chongqing, China. Int J Environ Res Public Health. 2015 Oct 26; 12(10):13455- 65. doi: 10.3390/ijerph121013455. PMID: 26516874; PMCID: PMC4627042.
8. Lazarte J, Hegele RA. Dyslipidemia management in adults with diabetes. Canadian journal of diabetes. 2020 Feb 1; 44(1):53–60.
doi: 10.1016/j.jcjd.2019.07.003.
9. Banach M, Surma S, Reiner Z, Katsiki N, Penson PE, Fras Z, et al. Personalized management of dyslipidemias in patients with diabetes—it is time for a new approach (2022). Cardiovasc Diabetol.2022: 21, 263 https://doi.org/10.1186/s12933-022-01684-5.
10. Verma SK, Maheshwari S, Singh RK, Chaudhari PK. Laser in dentistry: an innovative tool in modern dental practice. Natl J Maxillofac Surg. 2012; 3(2):124–132; doi: 10.4103/0975- 5950.111342.
11. Lin F, Josephs SF, Alexandrescu DT, Ramos F, Bogin V, Gammill V, et al. Lasers, stem cells, and COPD. J Transl Med. 2010 Feb; 8:16; doi: 10.1186/1479-5876-8-16. PMID: 20158898; PMCID: PMC2830167.
12. Makela AM. Theoretical backgrounds for light application in diabetes. Laser Florence; 2004.
13. Litscher G, Litscher D. A laser watch for simultaneous laser blood irradiation and laser acupuncture at the wrist. Integr Med Int. 2016; 3(1–2):75–81; doi: 10.1159/00044 8099.
14. Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci. 2014; 5(2):58– 62; doi:
10.22037/JLMS.V5I2.5540.
15. Litscher G, Bahr F, Litscher D. Yellow laser stimulation on the skull – first evidence of microcirculatory changes in the laboratory [in
German]. Akupunktur & Aurikulomedizin. 2015; 41(1):33–36; doi: 10.1007/s15009-015- 5319-y.
16. Hamblin MR. Ultraviolet irradiation of blood: “The cure that time forgot”? Adv Exp Med Biol. 2017; 996:295– 309; doi: 10.1007/978-3-319-56017-5_25.
17. Haslam DW, Wittert G, Seiler S, Tønnessen E. Fast Facts: Obesity. Intervals, thresholds, and long slow distance: the role of intensity and duration in endurance training. Sportscience.2009: 13: 32-53.
18. Mehta RK, Koirala P, Mallick RL, Parajuli S, Jha R. Dyslipidemia in Patients with Type 2 Diabetes Mellitus in a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2021 Apr 30; 59(236):305-309. doi: 10.31729/jnma.6278. PMID: 34508529; PMCID: PMC8369597.
19. Jackson FR, Roche GC and Wisler K. Reduction in cholesterol and triglyceride serum levels following low-level laser irradiation: a noncontrolled, nonrandomized pilot study. Am J Cosmet Surg. 2010; 27:177-84.
20. Serry ZM, El-Khashab SO, El-Monaem HA, Hamdy Elrefaey B. Response of glycaemic control to extravascular low level laser therapy in type 2 diabetic patients: a randomized clinical trial. Physiotherapy Quarterly.2021; 29(4):42-48. doi:10.5114/pq.2021.105752.
21. Kazemikhoo N, Ansari F, Nilforoushzadeh. The hypoglycemic effect of intravenous laser therapy in diabetic mellitus type 2 patients; a systematic review and metaanalyses. iMedPub Journals. 2015; 1(1):7; doi: 10.21767/ 2471- 299X.1000007.
22. Longo L. The role of laser in diabetes management. In: Waynant R, Tata DB (eds.), Proceedings of Light-Activated Tissue Regeneration and Therapy Conference. Boston: Springer; 2008; 215–220.
23. Irani S, Mohseni Salehi Monfared SS, AkbariKamrani M, Ostad SN, Abdollahi M, Larijani B. Effect of low-levellaser irradiation on in vitro function of pancreatic islets. Transplant Proc. 2009; 41(10):4313–4315; doi: 10.1016/ j.transproceed.2009.09.065.
24. Hakami AR, Alasmari S, Makkawi M, Mansour AA, Ahmad I, Al Shahrani M, et al. Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro. Med Lasers. 2020; 9 (2): 172- 178 https://doi.org/10.25289/ML.2020.9.2.172.
25. Melekhovets O, Smiianov Y, Rudenko L, Zhaldak D , Melekhovets J, Kovalenko E, et al. Efficiency of the Intravenous Laser Therapy in
Metabolic Disorders Correction. Acta Balneol, TOM LIX. 2017; 1(147):16-21.
26. Liu TC, Cheng L, Su W, Zhang Y, Shi Y, Liu A, et al Randomized, Double-Blind, and PlaceboControlled Clinic Report of Intranasal LowIntensity Laser Therapy on Vascular Diseases. International Journal of Photoenergy.2012; 2012 (489713) | https://doi.org/10.1155/2012/489713.
27. Lizarelli RFZ, Grecco C, Regalo SCH, Esteban Florez FL, Bagnato VS. A pilot study on the effects of transcutaneous and transmucosal laser irradiation on blood pressure, glucose and cholesterol in women. Heliyon. 2021 May 24; 7(5):e07110. doi: 10.1016/j.heliyon.2021.e07110. PMID:34136688; PMCID: PMC8180620.
28. Said MT and Elnhas NG. Impact of Cold Laser on Lipid Profile in Abdominal Obese. International Journal of PharmTech Research
Women. 2016; 9(10):115-120. CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455- 9563
29. Rushdi T. Effect of Low-Level Laser Therapy on cholesterol and triglyceride serum levels in ICU patients. Egyptian Journal of Cardiothoracic Anesthesia (EJCTA). 2010; 4(2):95-99.
30. Avci P, Nyame TT, Gupta GK, Sadasivam M, Hamblin MR. Low-level laser therapy for fat layer reduction: a comprehensive review. Lasers Surg Med. 2013 Aug; 45(6):349-57. doi:10.1002/lsm.22153. Epub 2013 Jun 7. PMID: 23749426; PMCID: PMC3769994.
31. Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O et al. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011 june; 21(6):722–729. doi: 10.1007/s11695- 010- 0126-y. PMID: 20393809; PMCID: PMC5225499.
32. Jackson RF, Stern FA, Neira R, Ortiz-Neira CL, Maloney J. Application of low-level laser therapy for noninvasive body contouring. Lasers Surg Med. 2012 Mar; 44(3):211-7. doi:10.1002/lsm.22007. Epub 2012 Feb 23. Erratum in: Lasers Surg Med. 2012 Sep; 44(7):597.
PMID: 22362380.
33. Jackson RF, Dedo DD, Roche GC, Turok DI, Maloney RJ. Low-level laser therapy as a noninvasive approach for body contouring: a
randomized, controlled study. Lasers Surg Med. 2009 Dec; 41(10):799-809. doi: 10.1002/lsm.20855. PMID: 20014253.
34. Mohamed RA, Yousef AM, Ata HK. Effect of electro acupuncture versus low level laser therapy on lipid profile in obesity. Phys Ther Rehabil. 2018; 5:9. http://dx.doi.org/10.7243/2055-2386- 5-9.
35. Al-Agamy NN, Al-Nahas N G, Obay HE. Cryolipolysis versus lipolysis versus cold laser on lipid profile and body composition in women with central obesity. Turkish Journal of Physiotherapy and Rehabilitation. 2021; 32(3). ISSN 2651-4451| e-ISSN 2651-446X.
www.turkjphysiotherrehabil.org
36. Nagy EN, Ibrahim FM, Jouda AA, Elsayed MM. The Effect of Laser Therapy Along With Mediterranean Diet versus Mediterranean Diet
Only on Older Adults with Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial. J Lasers Med Sci. 2021 Jul 24; 12:e39. doi:
10.34172/jlms.2021.39. PMID: 34733762; PMCID: PMC8558722.
37. Olban M, Wachowicz B, Koter M, Bryszewska M. The biostimulatory effect of red laser irradiation on pig blood platelet function. Cell
Biol Int. 1998; 22(3):245-8. doi:10.1006/cbir.1998.0251. PMID: 9974218.
38. Maahs DM, Ogden LG, Dabelea D, SnellBergeon JK, Daniels SR, Hamman RF, et al. Association of glycaemia with lipids in adults with type 1 diabetes: modification by dyslipidaemia medication. Diabetologia. 2010 Dec; 53(12):2518-25. doi: 10.1007/s00125-010- 1886-6. Epub 2010 Sep 4. PMID: 20820753; PMCID: PMC3405233.
39. Pietri AO, Dunn FL, Grundy SM, Raskin P. The effect of continuous subcutaneous insulin infusion on very-low-density lipoprotein
triglyceride metabolism in type I diabetes mellitus. Diabetes. 1983 Jan; 32(1):75-81. doi: 10.2337/diab.32.1.75. PMID: 6848399.
40. Tames FJ, Mackness MI, Arrol S, Laing I, Durrington PN. Non-enzymatic glycation of apolipoprotein B in the sera of diabetic and nondiabetic subjects. Atherosclerosis. 1992;93:237– 44.
2. IDF Diabetes Atlas 2019: Worldwide toll of diabetes. [Jun; 2020]; http://www.diabetesatlas.org/en/sections/worldw ide-toll-of-diabetes.html 2020. Federation I. D.(2019). IDF diabetes atlas ninth. Dunia: IDF.
3. Baynest HW. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J Diabetes Metab. 2015; 6(5):1000541; doi:10.4172/2155-6156.1000541.
4. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011 Dec; 94(3): 311-21. doi: 10.1016/j.diabres.2011.10.029. Epub 2011 Nov
12. PMID: 22079683.5. Jialal I, Singh G. Management of diabetic dyslipidemia: An update. World J Diabetes. 2019 May 15; 10(5):280-290. doi:10.4239/wjd.v10.i5.280. PMID: 31139315; PMCID: PMC6522756.
6. Mithal A, Majhi D, Shunmugavelu M, Talwarkar PG, Vasnawala H, Raza AS. Prevalence of dyslipidemia in adult Indian diabetic patients: A cross sectional study (SOLID). Indian J Endocrinol Metab. 2014 Sep; 18(5): 642-7. doi: 10.4103/2230-8210.139220. PMID: 25285280;
PMCID: PMC4171886.
7. Qi L, Ding X, Tang W, Li Q, Mao D, Wang Y. Prevalence and Risk Factors Associated with Dyslipidemia in Chongqing, China. Int J Environ Res Public Health. 2015 Oct 26; 12(10):13455- 65. doi: 10.3390/ijerph121013455. PMID: 26516874; PMCID: PMC4627042.
8. Lazarte J, Hegele RA. Dyslipidemia management in adults with diabetes. Canadian journal of diabetes. 2020 Feb 1; 44(1):53–60.
doi: 10.1016/j.jcjd.2019.07.003.
9. Banach M, Surma S, Reiner Z, Katsiki N, Penson PE, Fras Z, et al. Personalized management of dyslipidemias in patients with diabetes—it is time for a new approach (2022). Cardiovasc Diabetol.2022: 21, 263 https://doi.org/10.1186/s12933-022-01684-5.
10. Verma SK, Maheshwari S, Singh RK, Chaudhari PK. Laser in dentistry: an innovative tool in modern dental practice. Natl J Maxillofac Surg. 2012; 3(2):124–132; doi: 10.4103/0975- 5950.111342.
11. Lin F, Josephs SF, Alexandrescu DT, Ramos F, Bogin V, Gammill V, et al. Lasers, stem cells, and COPD. J Transl Med. 2010 Feb; 8:16; doi: 10.1186/1479-5876-8-16. PMID: 20158898; PMCID: PMC2830167.
12. Makela AM. Theoretical backgrounds for light application in diabetes. Laser Florence; 2004.
13. Litscher G, Litscher D. A laser watch for simultaneous laser blood irradiation and laser acupuncture at the wrist. Integr Med Int. 2016; 3(1–2):75–81; doi: 10.1159/00044 8099.
14. Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci. 2014; 5(2):58– 62; doi:
10.22037/JLMS.V5I2.5540.
15. Litscher G, Bahr F, Litscher D. Yellow laser stimulation on the skull – first evidence of microcirculatory changes in the laboratory [in
German]. Akupunktur & Aurikulomedizin. 2015; 41(1):33–36; doi: 10.1007/s15009-015- 5319-y.
16. Hamblin MR. Ultraviolet irradiation of blood: “The cure that time forgot”? Adv Exp Med Biol. 2017; 996:295– 309; doi: 10.1007/978-3-319-56017-5_25.
17. Haslam DW, Wittert G, Seiler S, Tønnessen E. Fast Facts: Obesity. Intervals, thresholds, and long slow distance: the role of intensity and duration in endurance training. Sportscience.2009: 13: 32-53.
18. Mehta RK, Koirala P, Mallick RL, Parajuli S, Jha R. Dyslipidemia in Patients with Type 2 Diabetes Mellitus in a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2021 Apr 30; 59(236):305-309. doi: 10.31729/jnma.6278. PMID: 34508529; PMCID: PMC8369597.
19. Jackson FR, Roche GC and Wisler K. Reduction in cholesterol and triglyceride serum levels following low-level laser irradiation: a noncontrolled, nonrandomized pilot study. Am J Cosmet Surg. 2010; 27:177-84.
20. Serry ZM, El-Khashab SO, El-Monaem HA, Hamdy Elrefaey B. Response of glycaemic control to extravascular low level laser therapy in type 2 diabetic patients: a randomized clinical trial. Physiotherapy Quarterly.2021; 29(4):42-48. doi:10.5114/pq.2021.105752.
21. Kazemikhoo N, Ansari F, Nilforoushzadeh. The hypoglycemic effect of intravenous laser therapy in diabetic mellitus type 2 patients; a systematic review and metaanalyses. iMedPub Journals. 2015; 1(1):7; doi: 10.21767/ 2471- 299X.1000007.
22. Longo L. The role of laser in diabetes management. In: Waynant R, Tata DB (eds.), Proceedings of Light-Activated Tissue Regeneration and Therapy Conference. Boston: Springer; 2008; 215–220.
23. Irani S, Mohseni Salehi Monfared SS, AkbariKamrani M, Ostad SN, Abdollahi M, Larijani B. Effect of low-levellaser irradiation on in vitro function of pancreatic islets. Transplant Proc. 2009; 41(10):4313–4315; doi: 10.1016/ j.transproceed.2009.09.065.
24. Hakami AR, Alasmari S, Makkawi M, Mansour AA, Ahmad I, Al Shahrani M, et al. Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro. Med Lasers. 2020; 9 (2): 172- 178 https://doi.org/10.25289/ML.2020.9.2.172.
25. Melekhovets O, Smiianov Y, Rudenko L, Zhaldak D , Melekhovets J, Kovalenko E, et al. Efficiency of the Intravenous Laser Therapy in
Metabolic Disorders Correction. Acta Balneol, TOM LIX. 2017; 1(147):16-21.
26. Liu TC, Cheng L, Su W, Zhang Y, Shi Y, Liu A, et al Randomized, Double-Blind, and PlaceboControlled Clinic Report of Intranasal LowIntensity Laser Therapy on Vascular Diseases. International Journal of Photoenergy.2012; 2012 (489713) | https://doi.org/10.1155/2012/489713.
27. Lizarelli RFZ, Grecco C, Regalo SCH, Esteban Florez FL, Bagnato VS. A pilot study on the effects of transcutaneous and transmucosal laser irradiation on blood pressure, glucose and cholesterol in women. Heliyon. 2021 May 24; 7(5):e07110. doi: 10.1016/j.heliyon.2021.e07110. PMID:34136688; PMCID: PMC8180620.
28. Said MT and Elnhas NG. Impact of Cold Laser on Lipid Profile in Abdominal Obese. International Journal of PharmTech Research
Women. 2016; 9(10):115-120. CODEN (USA): IJPRIF, ISSN: 0974-4304, ISSN(Online): 2455- 9563
29. Rushdi T. Effect of Low-Level Laser Therapy on cholesterol and triglyceride serum levels in ICU patients. Egyptian Journal of Cardiothoracic Anesthesia (EJCTA). 2010; 4(2):95-99.
30. Avci P, Nyame TT, Gupta GK, Sadasivam M, Hamblin MR. Low-level laser therapy for fat layer reduction: a comprehensive review. Lasers Surg Med. 2013 Aug; 45(6):349-57. doi:10.1002/lsm.22153. Epub 2013 Jun 7. PMID: 23749426; PMCID: PMC3769994.
31. Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O et al. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011 june; 21(6):722–729. doi: 10.1007/s11695- 010- 0126-y. PMID: 20393809; PMCID: PMC5225499.
32. Jackson RF, Stern FA, Neira R, Ortiz-Neira CL, Maloney J. Application of low-level laser therapy for noninvasive body contouring. Lasers Surg Med. 2012 Mar; 44(3):211-7. doi:10.1002/lsm.22007. Epub 2012 Feb 23. Erratum in: Lasers Surg Med. 2012 Sep; 44(7):597.
PMID: 22362380.
33. Jackson RF, Dedo DD, Roche GC, Turok DI, Maloney RJ. Low-level laser therapy as a noninvasive approach for body contouring: a
randomized, controlled study. Lasers Surg Med. 2009 Dec; 41(10):799-809. doi: 10.1002/lsm.20855. PMID: 20014253.
34. Mohamed RA, Yousef AM, Ata HK. Effect of electro acupuncture versus low level laser therapy on lipid profile in obesity. Phys Ther Rehabil. 2018; 5:9. http://dx.doi.org/10.7243/2055-2386- 5-9.
35. Al-Agamy NN, Al-Nahas N G, Obay HE. Cryolipolysis versus lipolysis versus cold laser on lipid profile and body composition in women with central obesity. Turkish Journal of Physiotherapy and Rehabilitation. 2021; 32(3). ISSN 2651-4451| e-ISSN 2651-446X.
www.turkjphysiotherrehabil.org
36. Nagy EN, Ibrahim FM, Jouda AA, Elsayed MM. The Effect of Laser Therapy Along With Mediterranean Diet versus Mediterranean Diet
Only on Older Adults with Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial. J Lasers Med Sci. 2021 Jul 24; 12:e39. doi:
10.34172/jlms.2021.39. PMID: 34733762; PMCID: PMC8558722.
37. Olban M, Wachowicz B, Koter M, Bryszewska M. The biostimulatory effect of red laser irradiation on pig blood platelet function. Cell
Biol Int. 1998; 22(3):245-8. doi:10.1006/cbir.1998.0251. PMID: 9974218.
38. Maahs DM, Ogden LG, Dabelea D, SnellBergeon JK, Daniels SR, Hamman RF, et al. Association of glycaemia with lipids in adults with type 1 diabetes: modification by dyslipidaemia medication. Diabetologia. 2010 Dec; 53(12):2518-25. doi: 10.1007/s00125-010- 1886-6. Epub 2010 Sep 4. PMID: 20820753; PMCID: PMC3405233.
39. Pietri AO, Dunn FL, Grundy SM, Raskin P. The effect of continuous subcutaneous insulin infusion on very-low-density lipoprotein
triglyceride metabolism in type I diabetes mellitus. Diabetes. 1983 Jan; 32(1):75-81. doi: 10.2337/diab.32.1.75. PMID: 6848399.
40. Tames FJ, Mackness MI, Arrol S, Laing I, Durrington PN. Non-enzymatic glycation of apolipoprotein B in the sera of diabetic and nondiabetic subjects. Atherosclerosis. 1992;93:237– 44.
Article Sidebar
Published
Mar 13, 2023
Article Details
How to Cite
Hany Mahmoud Fares, Hend Abd El-Moneam Abd El-Moneam, Asmaa Abdel Maksoud Ghanem, Basant Hamdy Elrefaey, & Tamer I. Abo Elyazed. (2023). Effect of Photo-Bio modulation on lipid profile in Patients with type 2 diabetes mellitus: A Randomized Clinical Trial. Journal of Population Therapeutics and Clinical Pharmacology, 30(3), 78–87. https://doi.org/10.47750/jptcp.2023.30.03.010
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.