TEMPORAL ASSESSMENT OF DELTAMETHRIN-INDUCED ORGAN WEIGHT VARIATIONS AND ENDOCRINE ALTERATIONS IN FEMALE ALBINO RATS
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Keywords
Deltamethrin, Female albino rats, Reproductive toxicity, Organ weight changes, Estrous cycle disruption
Abstract
The reproductive and systemic effects of deltamethrin exposure in female albino rats were examined in this study. For continuous intervals of two and four weeks, adult rats were given 50 mg/kg body weight of deltamethrin orally. Daily food and water intake, clinical symptoms, and behavioural changes were tracked in the control, vehicle-treated, and deltamethrin-exposed groups. The treated and control groups' feed and water intake did not differ significantly. On the other hand, four weeks of extended exposure led to clear toxic symptoms, such as loose faecal pellets, hyperirritability, and treatment-related death. Reproductive toxicity was demonstrated by the significant changes in body and organ weights brought on by deltamethrin exposure, as well as the disturbance of the oestrous cycle. At both time points, treated rats showed less body weight growth than controls. The weights of the liver and spleen decreased, but the weight of the kidney increased, according to the relative organ weight study. Furthermore, following two and four weeks of exposure, the thyroid and adrenal glands showed notable weight increases, indicating endocrine involvement. These results demonstrate that female rats exposed to deltamethrin orally over an extended period experience dose-dependent changes in their reproductive and systemic functions. Hormonal regulatory interference and cumulative toxic burden may be the cause of the observed physiological and organ-specific alterations. Overall, the findings highlight the possible risks to reproduction associated with extended exposure to deltamethrin and the significance of assessing pyrethroid safety considering female reproductive health.
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Dr. Anil Kumar
*Department of Anatomy, American International Institute of Medical Sciences (AIIMS), Near Transport Nagar, Airport Road, Bedwas, Udaipur - 313002 (Rajasthan)