DRUG DESIGN AND CHARACTERIZATION OF NANOSPONGES FOR ENHANCED SOLUBILITY OF POORLY SOLUBLE DRUGS
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Keywords
Nanosponges, β-Cyclodextrin, Poorly Soluble Drugs, Solubility Enhancement, Drug Delivery, Ibuprofen, Cross-linking.
Abstract
Nanosponges (NSs) represent a novel class of nanomaterials that have gained significant attention for their unique structural and physicochemical properties, particularly in the field of drug delivery. Aim of this study to provide a comprehensive overview of nanosponge-based drug delivery systems, focusing on their fundamental concepts, methods of preparation, and evaluation techniques. It further explores the current challenges encountered in both research and industrial- scale manufacturing. NSs are nano-sized, porous structures capable of encapsulating a wide variety of therapeutic agents—including proteins, enzymes, hydrophilic and lipophilic drugs, vaccines, and antibodies—enhancing their solubility, stability, bioavailability, and providing controlled or extended release. These systems can be synthesized using both organic and inorganic materials, offering several advantages such as biocompatibility, cost-effectiveness, improved stability, taste masking, and reduced side effects. This review also discusses various types of nanosponges, their synthesis methods, diverse applications, and characterization approaches. Overall, NSs show immense promise as multifunctional carriers, with the potential to significantly advance the field of nanomedicine.
Conclusion: Nanosponges significantly enhanced the solubility and release profile of the drug, suggesting a potential oral delivery platform for hydrophobic therapeutics.
References
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