VITAMIN D DEFICIENCY AND ITS ASSOCIATION WITH INFLAMMATORY MARKERS IN SICKLE CELL DISEASE PATIENTS: A TERTIARY CARE HOSPITAL STUDY.
Main Article Content
Keywords
Sickle cell disease, Genotype (SS, SB and AS) , Vitamin D, IL6, CRP ,Inflammatory parameter, Low Vit D group and Normal vit D group
Abstract
We investigated vitamin D deficiency in sickle cell disease patients and its association with inflammatory parameters. The study included 64 patients (33 SS and 31 SB) and 21 carriers (AS). Blood was obtained to assess levels of vitamin D, CRP, IL-6, The patients were grouped according to their genotype (SS, SB) and vitamin D status (low or normal). Carriers were also grouped as low or normal vitamin D. Laboratory findings were similar between low and normal Vit D groups in SS, SB and AS genotypes Acute chest syndrome was more frequent in SS-low Vit D (63%) compared to SS-normal Vit D (25%), SB-low Vit D (21%) and SBnormal Vit D (33%) (P = 0.045). Vit D was not a modifier of selected inflammation in sickle cell disease. Acute chest syndrome was comparably more frequent in SS-low vitamin D.
References
2. Brittain JE, Parise LV (2007) Cytokines and plasma factors in sickle cell disease. Curr Opin Hematol 14(5):438–443
3. Taylor SC, Shacks SJ, Qu Z et al (1997) Type 2 cytokine serum levels in healthy sickle cell disease patients. J Natl Med Assoc 89(11):753–757
4. Emokpae MA, Uadia PO, Gadzama AA (2010) Correlation of oxidative stress and inflammatory markers with the severity of sickle cell nephropathy. Ann Afr Med 9(3):141–146
5. Pathare A, Al Kindi S, Alnaqdy AA et al (2004) Cytokine profile of sickle cell disease in Oman. Am J Hematol 77:323–328
6. Prietl B, Treiber G, Pieber TR et al (2013) Vitamin D and immune function. Nutrients 5(7):2502–2521
7. Taylor SC, Shacks SJ, Mitchell RA et al (1995) Serum interleukin-6 levels in the steady state of sickle cell disease. J Interferon Cytokine Res 15(12):1061–1064
8. Jackson TC, Krauss MJ, Debaun MR et al (2012) Vitamin D deficiency and comorbidities in children with sickle cell anemia. Pediatr Hematol Oncol 29(3):261–266
9. Buison AM (2004) Low vitamin D status in children. J Pediatr 145:622–627
10. Rovner AJ, Stallings VA, Kawchak DA et al (2008) High risk of vitamin D deficiency in children with sickle cell disease. J Am Diet Assoc 108(9):1512–1516
11. Van Belle TL, Gysemans C, Mathieu C (2011) Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Best Pract Res Clin Endocrinol Metab 25(4):617–632
12. Chen S, Sims GP, Chen XX et al (2007) Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 179(3):1634–1647
13. Adegoke SA, Smith OS, Adekile AD et al (2017) Relationship between serum 25-hydroxyvitamin D and inflammatory cytokines in paediatric sickle cell disease. Cytokine 96:87–93.
14. Oztas Y, Durukan I, Unal S et al (2011) Plasma protein oxidation is correlated positively with plasma iron levels and negatively with hemolysate zinc levels in sickle-cell anemia patients. Int J Lab Hematol 34(2):129–135
15. Zorca S, Freeman L, Hildesheim M et al (2010) Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension. Br J Haematol 149(3):436–445
16. Rodriguez-Rodriguez E, Perea JM, Jimenez AI et al (2010) Fat intake and asthma in Spanish schoolchildren. Eur J Clin Nutr 64(10):1065–1071
17. Binkley N, Ramamurthy R, Krueger D (2012) Low vitamin D status: definition, prevalence, consequences, and correction. Rheum Dis Clin N Am 38(1):45–59
18. Jorde R, Grimnes G (2011) Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res 50(4):303–312
19. Muldoon MF, Marsland A, Flory JD et al (1997) Immune system differences in men with hypo- or hypercholesterolemia. Clin Immunol Immunopathol 84(2):145–149
20. Rudensky AY (2011) Regulatory T cells and Foxp3. Immunol Rev 241(1):260–268
21. Pathare A, Kindi SA, Daar S et al (2003) Cytokines in sickle cell disease. Hematology 8(5):329–337
22. Rego MJ, da Silva RR, Pereira MC et al (2015) Evaluation of CD4(?)CD25(?)FoxP3(?) T cell populations, IL-10 production, and their correlation with clinical and biochemical parameters in sickle cell anemia patients with leg ulcers. Cytokine 75(2):310–315
23. Lee MT, Licursi M, McMahon DJ (2015) Vitamin D deficiency and acute vaso-occlusive complications in children with sickle cell disease. Pediatr Blood Cancer 62(4):643–647
24. Novelli EM, Gladwin MT (2016) Crises in sickle cell disease. Chest 149(4):1082–1093
25. Tripette J, Connes P, Hedreville M et al (2010) Patterns of exercise-related inflammatory response in sickle cell trait carriers. Br J Sports Med 44(4):232–237
26. Adam SS, Zaher G, Ibrahim M et al (2008) Markers of coagulation activation and inflammation in sickle cell disease and sickle cell trait. Blood 112(11):4813
27. Unal S, Oztas Y, Eskandari G, Gumus LT, Nuriman O (2014) Association between vitamin D and inflammation in sickle cell disease. Blood 124(21):4923
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Pushpendra Narety
Assistant Professor, Department of Biochemistry, BRLSABVMMC, Rajnandgaon
Dr Mridula Bharti
Senior Resident, Department of Biochemistry, Phulo Jhano Medical College, Dumka
Dr Mithilesh Kumar
Junior Resident, Department of Biochemistry, RIMS, Ranchi