BIOAVAILABILITY AND PHARMACOKINETICS ,DRUG LIKELINESS PREDICTIONS OF BIOACTIVE COMPOUNDS OF LICORICE USING SWISS ADME SOFTWARE
Main Article Content
Keywords
ADMET LAB 3.0, licorice, bioactive compounds, medicinal plant, SWISS ADME, drug likeliness.
Abstract
BACKGROUND: Earlier research on licorice focused on documenting their bioactive compound profiles and traditional use. Before making a drug like substance prediction using information from in-silico experimental models. The current work aimed to examine and analyze the ADMET properties. This study assessed the drug-likeliness and ADMET characteristics of bioactive compounds from licorice.
MATERIALS AND METHODS:The current study will be the first to use the free online tool SWISS ADME to report the ADME characteristics of licorice. The ADME properties of five bioactive compounds from licorice were screened and the results were evaluated.
RESULT:Five bioactive compounds were identified to have good gastrointestinal absorption and can penetrate the brain . These compounds include Glycyrrhizic acid showing better lipophilicity, hydrogen bond donor and hydrogen bond acceptor.
CONCLUSION: This method is for determining the ADME characteristics of the bioactive compounds in Licorice. Based on the information, it was predicted that licorice would be effective in managing the disease. To validate these findings, it is advisable to conduct further controlled experimental research exploring the bioactive compounds’ pharmacological effects.
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Dr. N.V.V. Jagan Mohan Reddy
Professor, Department of Pharmaceitics, VJ' College of Pharmacy, Rajahmundry, Andhrapradesh -India
Varriswathi
Assistant Professor, Department of Pharmaceutics, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh- India.
Dr D.Narendra
Principal &Professor, Department of Pharmaceutical analysis, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh – India.
A.Anusha
Student, Department of Pharmacy, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh – India.
A.Uma Maheswari
Student, Department of Pharmacy, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh – India.
B.Aparna
Student, Department of Pharmacy, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh – India.
B.Lasya
Student, Department of Pharmacy, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh – India
B.Lakshmi Sreya
Student, Department of Pharmacy, VJ’s college of Pharmacy, Rajahmundry, Andhra Pradesh – India