A REVIEW OF THE DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ESTIMATION OF VORTIOXETINE HYDROBROMIDE AND LURASIDONE HYDROCHLORIDE
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Keywords
Vortioxetine Hydrobromide; Lurasidone Hydrochloride; Analytical Method Development; RP‑HPLC; LC‑MS/MS; Stability‑indicating methods.
Abstract
Analytical method development and validation are fundamental to pharmaceutical quality control, ensuring the identity, purity and potency of drug substances and finished products. Vortioxetine hydrobromide, an antidepressant with multimodal action, and Lurasidone hydrochloride, an atypical antipsychotic, are both clinically important central nervous system agents. A broad range of analytical techniques from simple spectrophotometric assays to chromatographic and mass‑spectrometric methods has been applied to their analysis in bulk drug, formulations and biological conditions. The aim of this review is to focus on update of method development and validation for vortioxetine and lurasidone, emphasizing UV spectrophotometry, RP-HPLC, UPLC, HPTLC, and LC–MS/MS. Comparative evaluation and future directions.
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Riya Patel
Department of Pharmaceutical Quality Assurance, Khyati College of Pharmacy.
Dr. Neha Tiwari
*Khyati College of Pharmacy, Palodia, Ahmedabad, Gujarat.
Dr. Pragnesh Patani
Head of Pharmacology department, Khyati College of Pharmacy, Ahmedabad, Gujarat, India.