EFFICACY OF PLATELET-RICH PLASMA IN KNEE OSTEOARTHRITIS: A ONE-YEAR PROSPECTIVE FOLLOW-UP STUDY
Main Article Content
Keywords
Platelet-Rich Plasma; Knee Osteoarthritis; Intra-articular Injection; Regenerative Medicine; VAS; WOMAC; One-Year Follow-Up
Abstract
Background: Knee osteoarthritis (OA) is a leading cause of pain and disability. Platelet-rich plasma (PRP) is an autologous biologic with regenerative potential. This study evaluated the efficacy and safety of intra-articular PRP in primary knee OA over one year.
Methods: Prospective, single-center study at Kamal Hospital, Tarn Taran (2017). Seventy-nine patients (102 knees) with Kellgren–Lawrence grade II–III OA received a single PRP injection. Assessments at baseline, 3, 6, and 12 months included VAS (pain) and WOMAC (function). Repeated-measures ANOVA tested changes over time (p<0.05 significant).
Results: VAS improved from 77.9 to 39.2 and WOMAC from 63.1 to 36.9 at 12 months (both p<0.001). At one year, 83.5% achieved ≥50% pain reduction. Adverse events were minor and transient (post-injection pain/stiffness in 24.1%).
Conclusion: Intra-articular PRP yielded clinically meaningful, sustained improvements in knee OA through one year, with an excellent safety profile.
References
2. Filardo G, et al. Am J Sports Med. 2011;39(6):1144–51.
3. Sánchez M, et al. Arthroscopy. 2012;28(8):1070–8.
4. Filardo G, et al. BMC Musculoskelet Disord. 2012;13:229.
5. Cerza F, et al. Int Orthop. 2012;36:1941–7.
6. Patel S, et al. Am J Sports Med. 2013;41(2):356–64.
7. Chang KV, et al. Arch Phys Med Rehabil. 2014;95(9):1759–72.
8. Laudy ABM, et al. Am J Sports Med. 2015;43(8):2028–37.
9. Filardo G, et al. Am J Sports Med. 2015;43(7):1575–82.
10. Sánchez M, et al. Cartilage. 2016;7(4):232–41.
11. Cole BJ, et al. Arthroscopy. 2017;33(9):1743–56.
12. Dai WL, et al. Arthroscopy. 2017;33(3):659–70.
13. Di Martino A, et al. Am J Sports Med. 2018;46(2):372–80.
14. Kon E, et al. Open Orthop J. 2013;7:120–8.
15. Sharma R, et al. Int J Orthop Traumatol Surg Sci. 2017;3(Spl Issue II):646–53.
16. Singh B, et al. Int J Orthop Traumatol Surg Sci. 2017;3(Spl Issue I):481–3.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Parampreet Singh
Consultant Orthopaedics, Kamal Hospital, Tarn Taran, Punjab, India
Nikhil Drolia
Consultant Orthopaedics, Patliputra Nursing Home, Dhanbad, India
Anupreet Kaur
Consultant Pathologist, Amandeep Hospital, Amritsar, India