TO STUDY THE PREVALENCE, RISK FACTORS AND GENOTYPE DISTRIBUTION OF HUMAN PAPILLOMAVIRUS INFECTION AMONG WOMEN WITH AND WITHOUT INVASIVE CERVICAL CANCER ATTENDING A TERTIARY CARE CENTRE
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Keywords
Prevalence, Risk Factors, Genotype, Distribution, Human Papillomavirus, Invasive Cervical Cancer.
Abstract
Introduction: Human papillomavirus (HPV) is the name of a group of 200 known viruses. They do not cause concerns in most people, but infection with some high-risk types is common and can cause genital warts or cancer. Human papillomavirus (HPV) infection is a well-established cause of invasive cervical cancer (ICC).
Aim and Objective: To study the prevalence, risk factors and genotype distribution of human papillomavirus infection among women with and without invasive cervical cancer in women.
Material and Methods: A hospital-based study was conducted among 1126 women aged 21–78 years attending a tertiary cancer centre. Cervical samples were tested by cytology and HPV DNA real-time PCR, followed by genotyping. Sociodemographic and clinical variables were assessed.
Results: The overall prevalence of HPV infection was 37.3% (420/1126). Higher HPV positivity was noted in women with cytological abnormalities: 73.7% in ASC-H/HSIL and 92.6% in invasive squamous cell carcinoma, compared with 26.1% in NILM. Histologically confirmed ICC was observed in 17.2% (194/1126), with 95.2% (185/194) being HPV-positive. HPV16 was the most prevalent genotype (76.5%), followed by HPV18 (10.2%). Risk factors significantly associated with HPV infection included age >50 years, low socioeconomic status, illiteracy, high parity, and marital duration >10 years (p<0.001).
Conclusion: HPV infection, particularly HPV16, was highly prevalent among women with premalignant and malignant cervical lesions. These findings highlight the urgent need for widespread HPV vaccination and cervical cancer screening strategies in the region.
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Dr. Mashkoor Ahmad
Assistant Professor, Department of Radiation Oncology, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Dr. Ramakant Tiwari
Assistant Professor, Department: Radiation Oncology, Sudha Medical College and Hospital, Kota, Rajasthan, India.
Dr. Mohammad Ali
Assistant Professor, Department of Radiation Oncology, Hind Institute of Medical Sciences, Safedabad, Barabanki, Uttar Pradesh, India.
Dr. Shoa Zehra
Senior Resident, Department of Microbiology, King George’s Medical University, Lucknow, Uttar Pradesh, India.
Dr Amit Kumar Singh
Assistant professor, Department of Microbiology, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.