TO STUDY THE EXPRESSION OF ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER-2-NEU RECEPTOR IN EPITHELIAL OVARIAN TUMORS
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Keywords
Epithelial ovarian tumors, Estrogen receptor, Progesterone receptor, HER-2/neu, Immunohistochemistry
Abstract
Background: Epithelial ovarian tumors represent the most common category of ovarian neoplasms and exhibit diverse biological behavior, ranging from benign to malignant lesions. Hormonal receptors such as estrogen receptor (ER) and progesterone receptor (PR), along with growth factor receptor HER-2/neu, have been implicated in tumorigenesis, progression, and prognosis of ovarian cancer. Immunohistochemical (IHC) evaluation of these markers provides insight into tumor biology and may guide therapeutic decision-making.
Objective: This study aimed to assess the expression of ER, PR, and HER-2/neu in epithelial ovarian tumors and to correlate their distribution across benign, borderline, and malignant categories.
Materials and Methods: A total of 50 epithelial ovarian tumors were studied, including 8 benign, 9 borderline, and 33 malignant cases. Immunohistochemistry was performed to evaluate ER, PR, and HER-2/neu expression.
Results: Among the 50 cases, benign, borderline, and malignant tumors comprised 16%, 18%, and 66% respectively. Most benign cases occurred in the 31–40 years age group, borderline tumors in 41–50 years, and malignant tumors also peaked in 41–50 years. ER expression was positive in 5 benign, all borderline, and 30 malignant cases. PR positivity was seen in 3 benign, 4 borderline, and 28 malignant tumors. HER-2/neu overexpression was restricted to malignant tumors (5 cases), with no positivity in benign or borderline groups.
Conclusion: ER and PR expression was observed across all categories but was more frequent in malignant tumors, whereas HER-2/neu positivity was exclusive to malignancies. These findings suggest that ER and PR may have prognostic significance, while HER-2/neu expression could serve as an indicator of malignant potential.
References
2. Vanderhyden, B. C., Shaw, T. J., Garson, K., Tonary, A. M. 2003. Ovarian carcinogenesis.
3. Merck Manual of diagnosis and therapy 18th edition; Section Gynaecology and obstetrics.
4. Day N.E, Krishan E. Epidemiology of gynaecology cancers. Gynaecology by Shaw R W. 2 ^ (nd) ed. Edinburgh: Churchill Living Stone, 1997; p.477-87.
5. Ellenson LH, Edyta C and Pirog. The female genital tract. Robbins and Cotran Pathologic Basis of Disease. 8(th) edition, Elsevier, A division of Reed Elsevier India Pvt. Ltd., 2010. Chapter 22:p. 1005-1063.
6. Shabani N, Mylonas I, Jeschke U, Thaqi A, Kuhn C, Puncher T. Expression of estrogen receptor alpha and beta and progesterone receptors A & Bin human mucinous carcinoma of endometrium, (Anticancer Res 2007. 27(4A):2027-33.
7. Pertschuk LP, Beddee AM, Gorelic LS, Shain SA immune cytochemical assay of estrogen receptor in Endometroid carcinoma with monoclonal antibodies Cancer 1986;57:1000-1004.
8. A Berchuck, A Kamel, R Whitaker et al. Overexpression of Her-2-/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Research 1990: 50: 4087-4091.
9. Tyagi SP, Madan A,Mohsin S, Hameed F,Saxena K. Epithelial tumors of the ovary Indian J Pathol Microbiol. 1978 Oct;21(4):281-9.
10. Mary T. Sylvia, Surendra Kumar, Papa Dasari. The expression of immunohistochemical markers estrogen receptor, progesterone receptor, Her-2-neu, p53 and Ki-67 in epithelial ovarian tumors and its correlation with clinicopathologic variables. Indian Journal of Pathology and Microbiology 2012; 55(1): 33-37.
11. Munnel EW, Taylor HC, Jr.: Ovarian carcinoma. A review of 200 primary and 51 secondary cases. Am J Obst and Gynec. 1949; 58:943-59.
12. Rhandhawa I,Lata P. A study of ovarian neoplasms.J Obstet Gynecol India. 1980;30:531-535.
13. Rajagopalan K, Rajagopalan C.K & Gourikutty A.K: Ovarian tumors a clinicopathological study. Ind J path Microb. 1982 79;73-75.
14. Prabhakar BR, Maingi K. Ovarian tumors prevalence in Punjab.Indian J Pathol Microbiol.1989 Oct;32(4):276-81.
15. Misra RK, Sharma SP, Gupta U,Gaur R,Misra SD: Pattern of ovarian neoplasm in eastern U.P. J obstet gynec India, 1991; 41: 242-46.
16. K.I.Quintyne, M., R. Landers, B. M.Cantwel Ovarian cancer expression of ER,PR, EGFR, and HER-2 in Irish women may predict for targeted therapies: A single institution experience. J Clin Oncol 26:2008(May 20 suppl; abstr 22179).
17. Larry C. Ford, Jonathan S. Berek, Leo D. Lagasse, Neville F. Hacker, Yvonne Heins, M.T., Fardad Esmailian, Ronald S. Leuchter, Robert J. Delange, Estrogen and Progestrone receptors in ovarian neoplasms Gynecologic Oncology Volume 15, Issue 3, June 1983, Pages 299-304.
18. N.Agarwal, D.L Roa, K. Murgeshan, U Verma, S. Mittal and T.N Chapekar. Clinical evaluation of steroid receptors in ovarian neoplasms.Int.J. Gynaecol. Obstet. 1987,25 145-149.
19. Bergqvist, S. Kullander and J. Thorell. A study of Estrogen and Progestrone Cytosol Receptor Concentration in Benign and Malignant Ovarian Tumors and A Review of Malignant Ovarian Tumors Treated with Medroxy-Progestrone Acetate Actaobstetr 1981, Vol.60,No. s101, Pages 75-81.
20. Hogdall EV, Christensen L, Hogdall CK, Blaakaer J, Gayther S, Jacobs IJ, Christensen IJ, Kjaer SK prognostic value of estrogen receptor and progesterone receptor tumor expression in Danish ovarian cancer patients: from the 'MALOVA' ovarian cancer study. Oncol Rep.2007 Nov;18(5):1051-9.
21. Tangjitgamol S, Manusirivithaya S, Khunnarong J, Jesadapatarakul S, Tanwanich S Expression of ER and PR in epithelial ovarian cancer:a clinicopathologic study. Int J Gynecol Cancer.2009 May;19(4):620-7.
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Dr Noorjahan Ali
Department Of Pathology, Skims Srinagar Kashmir
Dr Shazieya Akhtar
Department Of Pathology, Skims Srinagar Kashmir
Dr Parveen Shah
Department Of Pathology, Skims Srinagar Kashmir