Prevalence Of Odontogenic Tumours In Association With Age And Gender - An Institutional Study
Main Article Content
Keywords
odontogenic tumour; age; gender; prevalence; association; innovative technique
Abstract
Background: Odontogenic tumours are a complex, heterogenous group of lesions ranging from hamartomas to malignancies. There is a lack in the number of studies recording the prevalence rates and epidemiology of odontogenic tumours among the Indian population.
Aim: The current study aims to establish the association between age, gender and odontogenic tumour occurence.
Methodology: Data was collected from patients’ dental records from the department of oral pathology to meet the inclusion and exclusion criteria. A total of 640 records of patients who had undergone histopathological diagnosis were selected by random sampling and presence or absence of odontogenic tumours was analyzed in different gender and age. Descriptive analysis and chi-square tests were performed.
Results: Of the 640 examined subjects, only 11 patients were diagnosed with odontogenic tumour (0.1%). This study reveals that the prevalence of odontogenic among the study population was low. Unicystic ameloblastoma was the most commonly occurring OT. No significant correlation was found among gender or age.
Conclusion: Odontogenic tumour is a rare occurrence for the given patient demographics. However, knowledge regarding the relative incidence of odontogenic tumours across the globe, will likely improve the understanding of these lesions and this will in turn contribute significantly in determining treatment, its clinical outcomes and prognosis.
References
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25. Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, et al. Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Dec;86(6):707–14.
26. Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X, et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg. 2007 Jan;36(1):20–5.
27. Jaeger F, de Noronha MS, Silva MLV, Amaral MBF, Grossmann S de MC, Horta MCR, et al. Prevalence profile of odontogenic cysts and
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28. Raj A, Ramesh G, Nagarajappa R, Pandey A, Raj A. Prevalence of odontogenic lesions among the Kanpur population: an institutional study. J Exp Ther Oncol. 2017 May;12(1):35–42.
29. Santos JN, Pinto LP, de Figueredo CR, de Souza LB. Odontogenic tumors: analysis of 127 cases. Pesqui Odontol Bras. 2001 Oct;15(4):308–13.
30. Sousa FB, Etges A, Corrêa L. Pediatric oral lesions: a 15-year review from Sao Paulo, Brazil. Journal of Clinical [Internet]. 2002; Available from: https://meridian.allenpress.com/jcpd/article/26/4/413/76841
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32. Olgac V, Koseoglu BG, Aksakalli N. Odontogenic tumours in Istanbul: 527 cases. Br J Oral Maxillofac Surg. 2006 Oct;44(5):386–8.
33. Guerrisi M, Piloni MJ, Keszler A. Odontogenic tumors in children and adolescents. A 15-year retrospective study in Argentina. Med Oral Patol Oral Cir Bucal. 2007 May 1;12(3):E180–5.
34. Elarbi M, El-Gehani R, Subhashraj K, Orafi M. Orofacial tumors in Libyan children and adolescents. A descriptive study of 213 cases. Int J Pediatr Otorhinolaryngol. 2009 Feb;73(2):237–42.
35. Adebiyi KE, Ugboko VI, Omoniyi-Esan GO, Ndukwe KC, Oginni FO. Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med. 2006 Nov 24;2:42.
36. Tawfik MA, Zyada MM. Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):e67–73.
37. Fernandes AM, Duarte ECB, Pimenta FJGS, Souza LN, Santos VR, Mesquita RA, et al. Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Med. 2005 Nov;34(10):583–7.
38. Wu PC, Chan KW. A survey of tumours of the jawbones in Hong Kong Chinese: 1963–1982. Br J Oral Maxillofac Surg. 1985 Apr 1;23(2):92–
102.
39. Odukoya O. Odontogenic tumors: analysis of 289 Nigerian cases. J Oral Pathol Med. 1995 Nov;24(10):454–7.
40. Aregbesola B, Soyele O, Effiom O, Gbotolorun O, Taiwo O, Amole I. Odontogenic tumours in Nigeria: A multicentre study of 582 cases and
review of the literature. Med Oral Patol Oral Cir Bucal. 2018 Nov 1;23(6):e761–6.
41. Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005 Jun;63(6):811–9.
42. Tamme T, Soots M, Kulla A, Karu K, Hanstein SM, Sokk A, et al. Odontogenic tumours, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia. J Craniomaxillofac Surg. 2004 Jun;32(3):161–5.
43. Patil S, Halgatti V, Khandelwal S, Santosh BS, Maheshwari S. Prevalence of cysts and tumors around the retained and unerupted third molars in the Indian population. J Oral Biol Craniofac Res. 2014 May;4(2):82–7.
44. Anand S, Kashyap B, Kumar GR, Shruthi BS, Supriya AN. Pericoronal radiolucencies with significant pathology: clinico-histopathologic evaluation. Biomed J. 2015 Mar;38(2):148–52.
2. Regezi DDS MS J, James Sciubba D, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. Elsevier Health Sciences; 2016. 496 p.
3. Morgan PR. Odontogenic tumors: a review. Periodontol 2000. 2011 Oct;57(1):160–76.
4. Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran Pathologic Basis of Disease, Professional Edition E-Book. Elsevier Health Sciences; 2014. 1408 p.
5. Varkhede A, Tupkari JV, Sardar M. Odontogenic tumors: a study of 120 cases in an Indian teaching hospital. Med Oral Patol Oral Cir Bucal. 2011 Nov 1;16(7):e895–9.
6. Sriram G, Shetty RP. Odontogenic tumors: a study of 250 cases in an Indian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol
Endod. 2008 Jun;105(6):e14–21.
7. Garg K, Chandra S, Raj V, Fareed W, Zafar M. Molecular and genetic aspects of odontogenic tumors: a review. Iran J Basic Med Sci. 2015 Jun;18(6):529–36.
8. Saghravanian N, Jafarzadeh H, Bashardoost N, Pahlavan N, Shirinbak I. Odontogenic tumors in an Iranian population: a 30-year evaluation. J Oral Sci. 2010 Sep;52(3):391–6.
9. Soluk-Tekkeşin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2017
(4th) Edition. Turk Patoloji Derg [Internet]. 2018;34(1). Available from: http://dx.doi.org/10.5146/tjpath.2017.01410
10. Johnson NR, Gannon OM, Savage NW, Batstone MD. Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 2014 Feb;5(1):9–14.
11. Ramos G de O, Porto JC, Vieira DSC, Siqueira FM, Rivero ERC. Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil. Braz Oral Res. 2014;28:33–8
12. Kramer IR, Pindborg JJ, Shear M. The WHO Histological Typing of Odontogenic Tumours. A commentary on the Second Edition. Cancer. 1992 Dec 15;70(12):2988–94.
13. Gupta B, Ponniah I. The pattern of odontogenic tumors in a government teaching hospital in the southern Indian state of Tamil Nadu. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jul;110(1):e32–9.
14. Neelakantan P, Grotra D, Sharma S. Retreatability of 2 mineral trioxide aggregatebased root canal sealers: a cone-beam computed tomography analysis. J Endod. 2013 Jul;39(7):893–6.
15. Aldhuwayhi S, Mallineni SK, Sakhamuri S, Thakare AA, Mallineni S, Sajja R, et al. Covid-19 Knowledge and Perceptions Among Dental
Specialists: A Cross-Sectional Online Questionnaire Survey. Risk Manag Healthc Policy. 2021 Jul 7;14:2851–61.
16. Sheriff KAH, Ahmed Hilal Sheriff K, Santhanam A. Knowledge and Awareness towards Oral Biopsy among Students of Saveetha Dental College [Internet]. Vol. 11, Research Journal of Pharmacy and Technology. 2018. p. 543. Available from: http://dx.doi.org/10.5958/0974-360x.2018.00101.4
17. Markov A, Thangavelu L, Aravindhan S, Zekiy AO, Jarahian M, Chartrand MS, et al. Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders. Stem Cell Res Ther. 2021 Mar 18;12(1):192.
18. Jayaraj G, Ramani P, Herald J. Sherlin, Premkumar P, Anuja N. Inter-observer agreement in grading oral epithelial dysplasia – A systematic review [Internet]. Vol. 27, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2015. p. 112–6. Available from:
http://dx.doi.org/10.1016/j.ajoms.2014.01.006
19. Paramasivam A, Priyadharsini JV, Raghunandhakumar S, Elumalai P. A novel COVID-19 and its effects on cardiovascular disease. Hypertens Res. 2020 Jul;43(7):729–30.
20. Li Z, Veeraraghavan VP, Mohan SK, Bolla SR, Lakshmanan H, Kumaran S, et al. Apoptotic induction and anti-metastatic activity of eugenol encapsulated chitosan nanopolymer on rat glioma C6 cells via alleviating the MMP signaling pathway [Internet]. Vol. 203, Journal of Photochemistry and Photobiology B: Biology. 2020. p. 111773. Available from: http://dx.doi.org/10.1016/j.jphotobiol.2019.111773
21. Gan H, Zhang Y, Zhou Q, Zheng L, Xie X, Veeraraghavan VP, et al. Zingerone induced caspase-dependent apoptosis in MCF-7 cells and prevents 7,12-dimethylbenz(a)anthraceneinduced mammary carcinogenesis in experimental rats. J Biochem Mol Toxicol. 2019 Oct;33(10):e22387.
22. Dua K, Wadhwa R, Singhvi G, Rapalli V, Shukla SD, Shastri MD, et al. The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress. Drug Dev Res. 2019 Sep;80(6):714–30.
23. Mohan M, Jagannathan N. Oral field cancerization: an update on current concepts. Oncol Rev. 2014 Mar 17;8(1):244.
24. Nalabolu GRK, Mohiddin A, Hiremath SKS, Manyam R, Bharath TS, Raju PR. Epidemiological study of odontogenic tumours:
An institutional experience. J Infect Public Health. 2017 May;10(3):324–30.
25. Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, et al. Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Dec;86(6):707–14.
26. Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X, et al. Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg. 2007 Jan;36(1):20–5.
27. Jaeger F, de Noronha MS, Silva MLV, Amaral MBF, Grossmann S de MC, Horta MCR, et al. Prevalence profile of odontogenic cysts and
tumors on Brazilian sample after the reclassification of odontogenic keratocyst. J Craniomaxillofac Surg. 2017 Feb;45(2):267–70.
28. Raj A, Ramesh G, Nagarajappa R, Pandey A, Raj A. Prevalence of odontogenic lesions among the Kanpur population: an institutional study. J Exp Ther Oncol. 2017 May;12(1):35–42.
29. Santos JN, Pinto LP, de Figueredo CR, de Souza LB. Odontogenic tumors: analysis of 127 cases. Pesqui Odontol Bras. 2001 Oct;15(4):308–13.
30. Sousa FB, Etges A, Corrêa L. Pediatric oral lesions: a 15-year review from Sao Paulo, Brazil. Journal of Clinical [Internet]. 2002; Available from: https://meridian.allenpress.com/jcpd/article/26/4/413/76841
31. Osterne RLV, Brito RG de M, Alves APNN, Cavalcante RB, Sousa FB. Odontogenic tumors: a 5-year retrospective study in a Brazilian population and analysis of 3406 cases reported in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Apr;111(4):474–81.
32. Olgac V, Koseoglu BG, Aksakalli N. Odontogenic tumours in Istanbul: 527 cases. Br J Oral Maxillofac Surg. 2006 Oct;44(5):386–8.
33. Guerrisi M, Piloni MJ, Keszler A. Odontogenic tumors in children and adolescents. A 15-year retrospective study in Argentina. Med Oral Patol Oral Cir Bucal. 2007 May 1;12(3):E180–5.
34. Elarbi M, El-Gehani R, Subhashraj K, Orafi M. Orofacial tumors in Libyan children and adolescents. A descriptive study of 213 cases. Int J Pediatr Otorhinolaryngol. 2009 Feb;73(2):237–42.
35. Adebiyi KE, Ugboko VI, Omoniyi-Esan GO, Ndukwe KC, Oginni FO. Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med. 2006 Nov 24;2:42.
36. Tawfik MA, Zyada MM. Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):e67–73.
37. Fernandes AM, Duarte ECB, Pimenta FJGS, Souza LN, Santos VR, Mesquita RA, et al. Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Med. 2005 Nov;34(10):583–7.
38. Wu PC, Chan KW. A survey of tumours of the jawbones in Hong Kong Chinese: 1963–1982. Br J Oral Maxillofac Surg. 1985 Apr 1;23(2):92–
102.
39. Odukoya O. Odontogenic tumors: analysis of 289 Nigerian cases. J Oral Pathol Med. 1995 Nov;24(10):454–7.
40. Aregbesola B, Soyele O, Effiom O, Gbotolorun O, Taiwo O, Amole I. Odontogenic tumours in Nigeria: A multicentre study of 582 cases and
review of the literature. Med Oral Patol Oral Cir Bucal. 2018 Nov 1;23(6):e761–6.
41. Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005 Jun;63(6):811–9.
42. Tamme T, Soots M, Kulla A, Karu K, Hanstein SM, Sokk A, et al. Odontogenic tumours, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia. J Craniomaxillofac Surg. 2004 Jun;32(3):161–5.
43. Patil S, Halgatti V, Khandelwal S, Santosh BS, Maheshwari S. Prevalence of cysts and tumors around the retained and unerupted third molars in the Indian population. J Oral Biol Craniofac Res. 2014 May;4(2):82–7.
44. Anand S, Kashyap B, Kumar GR, Shruthi BS, Supriya AN. Pericoronal radiolucencies with significant pathology: clinico-histopathologic evaluation. Biomed J. 2015 Mar;38(2):148–52.
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Feb 13, 2023
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Sudarsan R, & Abilasha R. (2023). Prevalence Of Odontogenic Tumours In Association With Age And Gender - An Institutional Study. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 222–231. https://doi.org/10.47750/jptcp.2022.1004
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