ANTICANCER POTENTIALS OF INDIAN MADDER (RUBIA CORDIFOLIA L.):AN OVERVIEW
Main Article Content
Keywords
Rubia cordifolia, cancer, cell line, medicine,anti-cancer
Abstract
Rubia cordifolia is used as an age-old drug for cancer remedies. Even today, the potential activity of the plant is identified in various cell lines. The anthraquinones, flavonoids, etc are the compounds responsible for its anti-proliferating properties. It is believed that the possible mechanism behind the anti-proliferation is inhibition of DNA synthesis. The anthaquinone moiety, rubiadin, is found to be the most identified anticancer compound in the form of RA series. The recent advancement in biogenic nanoparticles using R. cordifolia was also found to be very effective in cancer treatment. Further clinical studies are needed before using this drug for modern pharmacopeia. The review article is intended to give an overall view of this magnificent plant in the treatment of cancer
References
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8. Itokawa, H., Saitou, K., Morita, H., Takeya, K., & Yamada, K. (1992). Structures and conformations of metabolites of antitumor cyclic hexapeptides, RA-VII and RA-X. Chemical and pharmaceutical bulletin, 40(11), 2984-2989.
9. Itokawa, H., Takeya, K., Mori, N., Hamanaka, T., Sonobe, T., & Mihara, K. (1984). Isolation and antitumor activity of cyclic hexapeptides isolated from Rubiae radix. Chemical and pharmaceutical bulletin, 32(1), 284-290.
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11. Itokawa, H., Yamamiya, T., Morita, H., & Takeya, K. (1992). New antitumour bicyclic hexapeptides, RA-IX and-X from Rubia cordifolia. Part 3. Conformation–antitumour activity relationship. Journal of the Chemical Society, Perkin Transactions 1, (4), 455-459.
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21. Patel, P.R., Nagar. A.A., Patel, R.C., Rathod, D.K., &Patel ,V.R. (2011) In vitro anticancer activity of Rubia cordifolia against HELA and HEP-2 cell lines, Int. J. Pharm. Pharm. Sci., 3, 70-71.115.
22. Patel, P.R., Raval, B.P., Karanth, H.A., Patel, V.R., Potent antitumor activity of Rubia cordifolia, Int. J. Phytomed. 2, 2010, 44-46.114.
23. Prajapati, H. A., Patel, D. H., Mehta, S. R., & Subramanian, R. B. (2003). Direct in vitro regeneration of CurculigoorchioidesGaertn., an endangered anticarcinogenic herb. Current science, 84(6), 747-749.
24. Priya, M.D., & Siril, E. A. (2013). Pharmacognostic studies on Indian madder (Rubia cordifolia L.). Journal of pharmacognosy and Phytochemistry, 1(5), 112-119.
25. Shilpa, P. N., Sivaramakrishnan, V., & Devaraj, S. N. (2012). Induction of apoptosis by methanolic extract of Rubia cordifolia Linn in HEp-2 cell line is mediated by reactive oxygen species. Asian Pac J Cancer Prev, 13(6), 2753-2758.
26. Shoemaker, M., Hamilton, B., Dairkee, S. H., Cohen, I., & Campbell, M. J. (2005). In vitro anticancer activity of twelve Chinese medicinal herbs. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 19(7), 649-651.
27. Sisubalan, N, Ramkumar, V.S,; Arivalagan, P; Karthikeyan, C & Indira, K. (2018). Environmental Science and Pollution Research; Heidelberg, 25 (11) 10482-10492. DOI:10.1007/s11356-017-0003
28. Sivarajan, V. V., & Balachandran, I. (1994). Ayurvedic drugs and their plant sources. Oxford and IBH publishing house, Nes Delhi.
29. Tiwari, S., Upadhyaya, R., Shroti, R., & Upadhyaya, S. T. (2012). Rubia cordifolia root extract induces apoptosis in cancer cell line. Sci. Secure J, 1(2), 39-42.
2. Adwankar, M. K., & Chitnis, M. P. (1982). In vivo Anti-cancer activity of RC-18: A Plant Isolate from Rubia cordifolia, Linn, against a spectrum of experimental tumour models. Chemotherapy, 28(4), 291-293.
3. Adwankar, M. K., Chitnis, M. P., Khandalekar, D. D., &Bhadsavale, C. G. (1980). Anti-cancer activity of the extracts of Rubia cordifolia Linn.(NSC b668893). Indian J Exp Biol. 18: 102-109
4. Balachandran P, Ibrahim MA, Zhang J, Wang M, Pasco DS, Muhammad I. Crosstalk of Cancer Signaling Pathways by Cyclic Hexapeptides and Anthraquinones from Rubia cordifolia. Molecules. 2021 Jan 31;26(3):735. doi: 10.3390/molecules26030735. PMID: 33572569; PMCID: PMC7866972.
5. Barlow, R., Barnes, D. A., Campbell, A. M., Nigam, P. S., & Owusu-Apenten, R. K. (2015). Antioxidant, anticancer and antimicrobial, effects of Rubia cordifolia aqueous root extract. Journal of Advances in Biology & Biotechnology 5(1): 1-8,
6. Chandraker, S. K., Lal, M., Khanam, F., Dhruve, P., Singh, R. P., & Shukla, R. (2022). Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract. Scientific reports, 12(1), 8831.
7. Hamanaka, T., Ohgoshi, M., Kawahara, K., Yamakawa, K., Tsuruo, T., &Tsukagoshi, S. (1987). A novel antitumor cyclic hexapeptide (RA-700) obtained from Rubiae radix. Journal of pharmacobio-dynamics, 10(11), 616-623.
8. Itokawa, H., Saitou, K., Morita, H., Takeya, K., & Yamada, K. (1992). Structures and conformations of metabolites of antitumor cyclic hexapeptides, RA-VII and RA-X. Chemical and pharmaceutical bulletin, 40(11), 2984-2989.
9. Itokawa, H., Takeya, K., Mori, N., Hamanaka, T., Sonobe, T., & Mihara, K. (1984). Isolation and antitumor activity of cyclic hexapeptides isolated from Rubiae radix. Chemical and pharmaceutical bulletin, 32(1), 284-290.
10. Itokawa, H., Takeya, K., Mori, N., Takanashi, M., Yamamoto, H., Sonobe, T., &Kidokoro, S. (1984). Cell growth-inhibitory effects of derivatives of antitumor cyclic hexapeptide RA-V obtained from Rubiae radix (V). GANN Japanese Journal of Cancer Research, 75(10), 929-936.
11. Itokawa, H., Yamamiya, T., Morita, H., & Takeya, K. (1992). New antitumour bicyclic hexapeptides, RA-IX and-X from Rubia cordifolia. Part 3. Conformation–antitumour activity relationship. Journal of the Chemical Society, Perkin Transactions 1, (4), 455-459.
12. Kato, T., Suzumura, Y., Takamoto, S., & Ota, K. (1987). Antitumor activity and toxicity in mice of RA-700, a cyclic hexapeptide. Anticancer Research, 7(3 Pt B), 329-334.
13. Khare, C. P. (2004). Encyclopedia of Indian medicinal plants: National Western therapy, Ayurvedic and another traditional usage, Botany. Springer.
14. Kintzios, S. E. (2006). Terrestrial plant-derived anticancer agents and plant species used in anticancer research. Critical reviews in plant sciences, 25(2), 79-113.
15. Lee YM, Auh QS, Lee DW, Kim JY, Jung HJ, Lee SH, Kim EC,Involvement of Nrf2-Mediated Upregulation of Heme Oxygenase-1 in Mollugin-Induced Growth Inhibition and Apoptosis in Human Oral Cancer Cells. Bio Med. Res. Int., 2013, 2013, e210604
16. Maitreya, B. B. (2015). An overview of Ethnomedicinal plants of Family Rubiaceae from Sabarmati River of Gujarat state, India. International Journal of Pharmacy & Life Sciences, 6(5).
17. Morita, H., Yamamiya, T., Takeya, K., Itokawa, H., Sakuma, C., Yamada, J., & Suga, T. (1993). Conformational recognition of RA-XII by 80S Ribosomes: a differential line broadening study in 1H NMR spectroscopy. Chemical and Pharmaceutical Bulletin, 41(4), 781-783.
18. Mughees M, Sharma Y, Ahmad J, Ahmad A (2016) Comparitive analysis of anticancer activity of Rubia cordifolia L. &Adultrant on MCF-7 cell and SCAR Marker Development. Int J Plant, Animal Environ Sci, 7: 70-79
19. Okhtia, Z. A., Al-Sudani, B. T., & Abdalah, M. E. (2020). Study the effect of Rubia cordifolia extract on different types of cancer cell lines and different microbial. Sys Rev Pharm, 11: 994-1000.
20. Patel, P.R,. Patel N.N.,, Suthar, M.P., Rajesh, K.S. & Patel, L.D. (2013) In vitro anti-cancer activity of Rubia cordifolia against HepG 32 Cell Line, Pharmagene, 1(1),-3.113.
21. Patel, P.R., Nagar. A.A., Patel, R.C., Rathod, D.K., &Patel ,V.R. (2011) In vitro anticancer activity of Rubia cordifolia against HELA and HEP-2 cell lines, Int. J. Pharm. Pharm. Sci., 3, 70-71.115.
22. Patel, P.R., Raval, B.P., Karanth, H.A., Patel, V.R., Potent antitumor activity of Rubia cordifolia, Int. J. Phytomed. 2, 2010, 44-46.114.
23. Prajapati, H. A., Patel, D. H., Mehta, S. R., & Subramanian, R. B. (2003). Direct in vitro regeneration of CurculigoorchioidesGaertn., an endangered anticarcinogenic herb. Current science, 84(6), 747-749.
24. Priya, M.D., & Siril, E. A. (2013). Pharmacognostic studies on Indian madder (Rubia cordifolia L.). Journal of pharmacognosy and Phytochemistry, 1(5), 112-119.
25. Shilpa, P. N., Sivaramakrishnan, V., & Devaraj, S. N. (2012). Induction of apoptosis by methanolic extract of Rubia cordifolia Linn in HEp-2 cell line is mediated by reactive oxygen species. Asian Pac J Cancer Prev, 13(6), 2753-2758.
26. Shoemaker, M., Hamilton, B., Dairkee, S. H., Cohen, I., & Campbell, M. J. (2005). In vitro anticancer activity of twelve Chinese medicinal herbs. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 19(7), 649-651.
27. Sisubalan, N, Ramkumar, V.S,; Arivalagan, P; Karthikeyan, C & Indira, K. (2018). Environmental Science and Pollution Research; Heidelberg, 25 (11) 10482-10492. DOI:10.1007/s11356-017-0003
28. Sivarajan, V. V., & Balachandran, I. (1994). Ayurvedic drugs and their plant sources. Oxford and IBH publishing house, Nes Delhi.
29. Tiwari, S., Upadhyaya, R., Shroti, R., & Upadhyaya, S. T. (2012). Rubia cordifolia root extract induces apoptosis in cancer cell line. Sci. Secure J, 1(2), 39-42.
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Published
Dec 20, 2022
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How to Cite
Devi Priya M., Vinod Kumar TG, Francis Mathew, & Asha Saji. (2022). ANTICANCER POTENTIALS OF INDIAN MADDER (RUBIA CORDIFOLIA L.):AN OVERVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 29(5), 101-105. https://doi.org/10.53555/wm7z9315
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Author Biographies
Devi Priya M.
Department of Botany, St. Thomas College, Pazhavangadi PO, Ranni
Vinod Kumar TG
Department of Botany, St. Thomas College, Pazhavangadi PO, Ranni
Francis Mathew
Department of Botany, St. Thomas College, Pazhavangadi PO, Ranni
Asha Saji
Department of Botany, St. Thomas College, Pazhavangadi PO, Ranni
How to Cite
Devi Priya M., Vinod Kumar TG, Francis Mathew, & Asha Saji. (2022). ANTICANCER POTENTIALS OF INDIAN MADDER (RUBIA CORDIFOLIA L.):AN OVERVIEW. Journal of Population Therapeutics and Clinical Pharmacology, 29(5), 101-105. https://doi.org/10.53555/wm7z9315