PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGINOSA ISOLATED FROM WOUND INFECTIONS: A HOSPITAL-BASED STUDY AT PJMCH, DUMKA, JHARKHAND
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Keywords
Pseudomonas aeruginosa, Antibiotic susceptibility
Abstract
Background: Pseudomonas aeruginosa is a common opportunistic pathogen frequently associated with hospital-acquired infections, particularly wound and pus infections. Its increasing resistance to multiple antibiotics poses a significant therapeutic challenge. This study was undertaken to evaluate the prevalence and antibiotic susceptibility pattern of P. aeruginosa isolated from pus samples in a tertiary care hospital.
Methods: A total of 376 pus samples were processed in the Department of Microbiology, PJMCH, Dumka, Jharkhand, from January to December 2023. Isolates were identified using standard microbiological methods, and antimicrobial susceptibility testing was performed by Kirby–Bauer disc diffusion according to CLSI guidelines.
Results: Out of 376 samples, 37 (9.84%) yielded P. aeruginosa. The highest prevalence was noted in the 40–49 years age group (37.84%) with male predominance (67.57%). Antibiotic susceptibility testing revealed highest sensitivity to piperacillin/tazobactam (78.38%), imipenem (78.38%), aztreonam (78.38%), and meropenem (75.68%), while resistance was most frequent against ofloxacin (48.65%) and ciprofloxacin (37.84%). The overall prevalence of multidrug-resistant (MDR) isolates was 21.62%.
Conclusion: P. aeruginosa remains an important cause of wound infections with considerable antimicrobial resistance. Continuous surveillance of antibiograms and judicious use of antimicrobials are essential to guide empirical therapy and prevent the emergence of MDR strains.
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Dr. Ramjanam Prasad
Senior Resident, Department of Microbiology, Phulo Jhano Medical College Dumka, Jharkhand, India
Dr. Vikas Oraon
Assistant Professor, Department of Microbiology, Phulo Jhano Medical College Dumka, Jharkhand, India
Dr. Pinki Kumari
Professor, Department of Microbiology, Phulo Jhano Medical College Dumka, Jharkhand, India
Dr. Jiwesh Kumar Thakur
Professor, Department of Surgery, Gouri Devi Institute of Medical Sciences and Hospital, Durgapur, West Bengal, India
Dr. Satyendra Prasad Yadav
Senior Resident, Department of Microbiology, Phulo Jhano Medical College Dumka, Jharkhand, India