SPECIES DISTRIBUTION AND ANTIFUNGAL SUSCEPTIBILITY OF INVASIVE CANDIDIASIS IN TERTIARY CARE RURAL HOSPITAL IN CENTRAL INDIA: AN OBSERVATIONAL STUDY
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Keywords
Invasive candidiasis, Candida, antifungal resistance, species distribution, (BacT/ALERT 3D)
Abstract
Invasive candidiasis (IC), a potentially lethal illness that affects hospitalised patients, is still mostly ignored by the public health sector. People with impaired immune systems are at serious risk due to the paucity of worldwide epidemiological data on IC and the limits of diagnosis. Effective therapy requires exposure to antifungal medications and knowledge of the presence of Candida species.
Materials & Methods:Over the course of 18 months, 35 different species of Candida were identified in IC patients' blood and other sterile bodily fluids. "An automated technique was used to determine fungal susceptibility and species identification. (BacT/ALERT 3D and Vitek 2).
Results:In the present study it was observed thatNon-albicans Candida species predominated (83%), withC. parapsilosis (26%), C.tropicalis(17%), C. ciferrii (14%), C. famata (8%), C. auris (6%), C. glabrata (3%), and C. krusei (3%). C. albicans comprised16%of the isolates. Overall, 69% of the samples tested were resistant to fluconazole, while 60% of the samples tested were somewhat resistant to micafungin and caspofungin. With 88% of isolates being responsive, amphotericin B showed the greatest level of sensitivity.
Conclusion:The research sheds light on the evolving epidemiology of candida species that cause IC, which is vital knowledge. In addition, it discusses how to choose empirical antifungal drugs for treating infections caused by candida species other than C. albicans.
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Dr. Shweta Kumari
Assistant professor, Department of Microbiology, Integral Institute of Medical Science and Research, Lucknow, Uttar Pradesh, India.
Dr. Dipak Thamke
Professor, Department of Microbiology, MGIMS Sevagram, Wardha, Maharastra, India.
Dr.Ajay Kumar
Assistant professor, Department of Plastic surgery ,Command hospital Lucknow, , Uttar Pradesh, India.