CHARACTERIZING BREAST CANCER STAGES ON THE BASIS OF CORRELATION
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Keywords
TNM classification, metastasis, correlation
Abstract
Aim of the study was to characterize the different stages of breast cancer and their role in early diagnosis and prognosis. Qualitative data in different stages of breast cancer showed maximum cases of stage 3 (T3) n= 85 among all stages. Out of 85 patients n=67 belong to T3N0M0, means carcinoma in situ with size of tumor greater than 5cm, no nodal involvement and metastasis. Cases n=2 belong to T3NIMO and T3N2M1, means carcinoma in situ with size of tumor greater than 5cm, fixed nodal involvement with or without metastasis. Maximum frequency of patients noted in stage 4 then stage 2 frequency noted increased. Least were of stage 1. Metastasis to ipsilateral, non-matted and small in size lymph node was more frequent after that to contralateral, either bigger in size or matted lymph nodes. Correlation between different stages and metastasis showing a significant association noted among stages and metastasis to nodes and other organs.
CONCLUSIONS: The study shows good prognosis and beneficial role of TNM staging in hormone receptor-positive breast cancer as it shows delay metastasis to lymph nodes and other tissues.
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Hoor Fatima
MBBS, M.Phil., Ph.D. Associate Professor Biochemistry, SMBBMC Karachi, Pakistan
Ashhad Mazhar Siddiqi
MBBS, M.Phil, Assistant Professor Anatomy Department Dow Medical College Dow University of Health Sciences Karachi
Sikandar Adil Mughal
MBBS, M.Phil, Professor Physiology Physiology Department Dow Medical College Dow University of Health Sciences Karachi
Muhammad Khalid Siddiqui
MBBS, M.Phil, Assistant Professor Physiology Department Dow Medical College Karachi
Mehak Memon
MBBS. M. Phil, Ph.D. Scholar Assistant Professor Biochemistry Department PUMHS Shaheed Banazirabad
Sara Farhan
MBBS, M.Phil Assistant Professor Anatomy DIMC DUHS, Karachi, Pakistan