EXPLORING THE LINK BETWEEN THE 2D:4D RATIO, BLOOD PRESSURE, AND LIPID PROFILE IN A MALE POPULATION FROM NORTH INDIA.
Main Article Content
Keywords
2D:4D Ratio, Finger Length Ratio, Coronary Artery Disease (CAD), Cardiovascular Risk, Male Health.
Abstract
Background: The 2D:4D finger length ratio, known for its sexual dimorphism and association with various traits, has been investigated as a potential marker for cardiovascular disease. This study aimed to determine if 2D:4D ratios correlate with coronary artery disease (CAD) in males, as assessed by ECG, 2D-ECHO, and coronary angiography.
Methods: This cross-sectional study included 100 male subjects aged 30-80 years, divided into two groups: 50 with diagnosed CAD and 50 without. Digital calipers were used to measure the lengths of the index (2D) and ring (4D) fingers of both hands, with measurements taken twice for accuracy. Data were analyzed using appropriate statistical methods.
Results: Males with CAD exhibited significantly higher 2D:4D ratios compared to those without CAD (P < 0.01). This finding indicates a positive correlation between elevated 2D:4D ratios and the presence of CAD in male subjects.
Conclusion: This study suggests that the 2D:4D finger length ratio may serve as a potential marker for predisposition to CAD in males. Higher 2D:4D ratios were associated with a significantly increased likelihood of CAD, as confirmed by clinical assessments.
References
2. Manning, J. T. (2002). Digit ratio: A pointer to fertility, behaviour, and health. Rutgers University Press.
3. Manning, J. T., Barley, L., Walton, J., Lewis-Jones, D. I., Trivers, R. L., & Singh, D. (2000). The 2nd: 4th digit ratio and variation in the androgen receptor gene. Evolution and Human Behavior, 21(3), 163-173.
4. Zheng, Z. J., & Cohn, M. J. (2011). Developmental basis of sexually dimorphic digit ratios. Proceedings of the National Academy of Sciences, 108(39), 16289-16294. 1
5. Hiraishi, A., Shibata, H., & Suzuki, T. (2012). Association between the second-to-fourth digit ratio and coronary artery disease. Atherosclerosis, 222(2), 478-482.
6. Hiraishi, A., Shibata, H., & Suzuki, T. (2013). The second-to-fourth digit ratio and the severity of coronary artery disease. International Journal of Cardiology, 167(6), 2824-2827.
7. Kim, J. H., Lee, S. H., Park, J. H., & Kim, J. H. (2015). Association between the second-to-fourth digit ratio and metabolic syndrome in Korean men. Endocrine Journal, 62(1), 77-83.
8. Trivers, R. L., Manning, J. T., Jacobson, A., & Singh, D. (2006). Second to fourth digit ratio (2D: 4D) and hand shape in Jamaican children. Laterality, 11(4), 305-316.
9. Voracek, M., & Manning, J. T. (2003). Associations between digit ratio (2D: 4D) and self-reported physical aggression in Austrian adults: further evidence for a prenatal hormonal link to adult behavior. Hormones and Behavior, 43(1), 264-270.
10. Hone, L. S., & McCullough, J. M. (2005). The nature of nurture: testosterone as a link between genes and environment. Journal of Biosocial Science, 37(6), 769-786.
11. Manning, J. T., Kilduff, L. P., & Cook, C. J. (2014). Digit ratio (2D: 4D) and sports performance. Journal of Sports Sciences, 32(1), 1-10.
12. Breedlove, S. M. (2010). Prenatal influences on sexual orientation. Journal of Neuroendocrinology, 22(5), 491-498.
13. Fink, B., Neave, N. J., & Manning, J. T. (2003). Second to fourth digit ratio (2D: 4D) and hand preferences in estonian children. Laterality, 8(1), 43-52.
14. Manning, J. T., & Robinson, S. J. (2003). Second to fourth digit ratio, aggression and sexual dimorphism in humans. Evolution and Human Behavior, 24(1), 42-61.
15. Manning, J. T., Trivers, R. L., Thornhill, R., & Singh, D. (2004). The 2nd: 4th digit ratio and variation in the human androgen receptor gene: further evidence for an association. Evolution and Human Behavior, 25(4), 243-249.
16. Berenbaum, S. A., & Bailey, J. M. (2003). Prenatal sex hormones and childhood gender typicality. Developmental Psychology, 39(1), 143.
17. Hönekopp, J., Bartholdt, L., Beier, L., & Lietzmann, T. C. (2006). Second to fourth digit ratio (2D: 4D) and digit lengths in Europeans: a meta-analysis. Human Nature, 17(4), 385-400.
18. Loehlin, J. C., Horn, J. M., & Willerman, L. (1994). Heredity, environment, and IQ in the Texas Adoption Project. Intelligence, 19(3), 263-282.
19. Manning, J. T. (2011). The 2D: 4D ratio: facts and fallacies. Progress in Brain Research, 189, 137-145.
20. Breedlove, S. M. (1997). Sex on the brain. Nature, 389(6649), 330-331.