EFFECT OF CONTINUOUS POSITIVE AIRWAY PRESSURE THERAPY ON LIPID PROFILE OF OBSTRUCTIVE SLEEP APNEA PATIENTS
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Keywords
Apnea-Hypopnea Index, sleep efficiency%, Body Mass Index, Obstructive sleep apnea
Abstract
: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder which causes repetitive episodes of partial or complete obstruction of upper airway during sleep, which lead to intermittent hypoxia, Sleep fragmentation, oxidative stress or inflammation. If OSAS is not treated on time then it may cause dyslipidaemia. Continuous positive airway pressure (CPAP) eliminates OSAS and help you breathe during sleep. In this study attempt is made to find that whether CPAP therapy in patients having OSAS really improve dyslipidaemia.
Materials and Method: Polysomnography for all these volunteers were done from 10 pm to 6 am after obtaining their written consent at Sleep Research Centre. Subjects having AHI ≥ 5, which was obtained from polysomnogram, were included in the study. At around 6:30 am, after polysomnography recording is over, blood sample was collected for finding lipid profile of these subjects. Then subjects were made to use CPAP while sleeping in night for 2 months. After Two months of CPAP use polysomnography recording and lipid profile test of these subjects were done again. Then comparison between all parameters of subjects before CPAP use and after CPAP use were done.
Results: CPAP use increases sleep efficiency%, mean TBI SPo2%, High-density lipoprotein (HDL) significantly. It decreases Apnea-Hypopnea Index (AHI) significantly. It also insignificantly decreases Total cholesterol (TC), Triglycerides (TG), low density lipoprotein (LDL), Very Low-Density Lipoprotein (VLDL).
Conclusions: CPAP treatment causes significant reduction in OSA, increases oxygen saturation and sleep efficiency significantly but improve dyslipidaemia insignificantly.
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Dr. Santosh Kumar Sah
Associate professor, Department of Physiology, Krishna Mohan Medical College & Hospital, Mathura, U.P India
Dr. Safia Maqbool
Associate professor, Department of Microbiology, Krishna Mohan Medical College and Hospital, Mathura, U.P India
Dr. Ankur Shah
Associate Professor, Department of Biochemistry, Pacific Medical College & Hospital, Udaipur, Rajasthan.