CLINICAL PROFILE OF PAEDIATRIC PATIENTS WITH URINARY TRACT INFECTION IN A TERTIARY CARE CENTRE
Main Article Content
Keywords
Urinary tract infection, Pediatrics, Clinical profile, Escherichia coli, Risk factors
Abstract
: Urinary tract infection (UTI) is one of the most common bacterial infections in children, with varied clinical presentations and potential for long-term renal damage if untreated. Understanding the clinical profile helps in early diagnosis and management.
Objectives: To study the clinical features, laboratory findings, microbiological profile, and risk factors associated with pediatric UTIs in a tertiary care hospital.
Materials and Methods: This observational study was conducted in the department of Paediatrics at a tertiary care hospital. Our study included 100 children aged 1 month to 18 years with culture-proven UTI. Detailed demographic, clinical, laboratory, and microbiological data were collected and analyzed.
Results: Of the 100 cases, 65% were females and 35% males, with the highest prevalence in the 1–5 years age group (40%). The predominant presenting feature was fever (82%), followed by dysuria (45%), increased frequency of micturition (40%), and abdominal pain (35%). Infants commonly presented with nonspecific symptoms such as poor feeding (15%) and irritability (12%). Laboratory evaluation revealed pyuria in 80% and leukocytosis in 55% of cases. Urine culture showed Escherichia coli (70%) as the most common pathogen, followed by Klebsiella (15%), Proteus (8%), and Enterococcus (7%). Identifiable risk factors included poor perineal hygiene (15%), vesicoureteral reflux (12%), and constipation (10%).
Conclusion: UTI is more prevalent among females and in the 1–5 years age group. Fever is the most frequent symptom, but nonspecific manifestations in infants make diagnosis challenging. E. coli remains the leading pathogen. Recognition of associated risk factors such as poor hygiene, VUR, and constipation is essential for prevention and recurrence control.
References
2. Smellie JM, Rigden SP, Prescod NP. Urinary tract infection: a comparison of four methods of investigation. Arch Dis Child. 1995;72(3):247–250.
3. Coulthard MG, Lambert HJ, Keir MJ. Occurrence of renal scars in children after their first referral for urinary tract infection. BMJ. 1997;315:918–919.
4. Swerkersson S, Jodal U, Åhrén C, Hansson S. Urinary tract infection in small children: the evolution of renal damage over time. Pediatr Nephrol. 2017;32(10):1907–1913.
5. Zorc JJ, Kiddoo DA, Shaw KN. Diagnosis and management of pediatric urinary tract infections. Clin Microbiol Rev. 2005;18(2):417–422.
6. Elder JS. Urinary tract infections. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, editors. Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier; 2020. p. 2761–2771.
7. NICE Clinical Guideline. Urinary tract infection in under 16s: diagnosis and management. National Institute for Health and Care Excellence (NICE); 2018.
8. Hoberman A, Wald ER, Hickey RW, et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999;104(1):79–86.
9. Tullus K. Difficulties in diagnosing urinary tract infections in small children. Pediatr Nephrol. 2011;26(11):1923–1926.
10. Bryce A, Hay AD, Lane IF, Thornton HV, Wootton M, Costelloe C. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli: a systematic review and meta-analysis. BMJ. 2016;352:i939.
11. Saha S, Nayak S, Bhattacharyya I, Saha S. Pattern of antibiotic resistance in uropathogens: a retrospective hospital-based study. Indian J Med Microbiol. 2019;37(1):46–51.
12. Montini G, Tullus K, Hewitt I. Febrile urinary tract infections in children. N Engl J Med. 2011;365(3):239–250.
13. Shaikh N, Morone NE, Lopez J, Chianese J, Sangvai S, D’Amico F, Hoberman A, Wald ER. Does this child have a urinary tract infection? JAMA. 2007;298(24):2895-2904.
14. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics. 2010;126(6):1084-1091.
15. Bagga A, Sharma J. Urinary tract infections in children. In: Ghai OP, Paul VK, Bagga A, editors. Ghai Essential Pediatrics. 7th ed. New Delhi: CBS Publishers; 2011. p. 523-526.
16. Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011;128(3):595-610.
17. Bhat RG, Katy TA, Place FC. Pediatric urinary tract infections. Emerg Med Clin North Am. 2011;29(3):637-653.
18. Kothari A, Sagar V. Antibiotic resistance in pathogens causing community-acquired urinary tract infections in India: a multicenter study. J Infect Dev Ctries. 2008;2(5):354-358.
19. Sanghvi KP, Anjan A. Risk factors for urinary tract infection in children. Int J Contemp Pediatr. 2017;4(2):436-440.
20. Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, et al. Recurrent urinary tract infections in children with and without vesicoureteral reflux. Pediatrics. 2016;137(1):e20152982.