THE ROLE OF HISTOLOGIC RISK ASSESSMENT AS A PROGNOSTIC INDICATOR IN ORAL SQUAMOUS CELL CARCINOMA
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Keywords
Histological risk score, oral squamous cell carcinoma, prognosis, histological parameters.
Abstract
Background: Oral squamous cell carcinoma (OSCC) is the most common carcinoma affecting the oral cavity comprising of more than 90% of all oral cancers.The tumor staging of OSCC shows heterogenous prognosis with increased number of patients with loco regional recurrence (LRR) and decreased disease free survival (DFS) related to mortality.
Aims and Objectives: To evaluate the parameters used in Brandwein‑Gensler risk model along with lympho‑vascular invasion (LVI), depth of invasion (DOI) and lymph node metastases in predicting loco regional recurrence (LRR)in OSCC.
Materials and Methods: This was a retrospective study on
T1/2 OSCC patients over a period of 2 years who received treatment by surgical
resection. LRR was examined based on recurrence of OSCC at the initial site or in regional lymph nodes.
Results: During our study period a total of 56 cases befitted our inclusion criteria. Univariate analysis identified LVI (P =0.627), DOI (P = 0.116), nodal involvement (P =0.107), WPOI (P =0.084), LHR (P = 0.280) and only risk category (P< 0.001) showed strong statistically significant risk factor for LRR.
Conclusion: Adequate assessment of all the parameters on routine H and E by including Brandwein‑Gensler histological risk scoring model at the initial assessment can help in the prognosis and further treatment of the patients with OSCC.
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Chaithra H
Associate Professor, Department of Pathology, Sri Siddhartha Medical college Tumkur‑ 572107, karnataka, India.
Geetha J P
Professor & HOD, Department of Pathology, Sri Siddhartha Medical college Tumkur‑ 572107, Karnataka, India.
Lokesh M R
Professor, Department of General Medicine, Sri Siddhartha Medical college Tumkur‑ 572107, Karnataka, India.