EFFECT OF MONOSODIUM GLUTAMATE ON THE MICROSCOPIC ANATOMY OF THYROID GLAND IN MALE RABBITS
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Abstract
: Monosodium Glutamate is a commonly used food additive owing to its “meaty” taste. However prolonged intake of MSG adversely affects all organs of the body.
AIMS AND OBJECTIVES: This study aims to study the histological effect of monosodium glutamate on thyroid gland of adult male rabbits.
METHODOLOGY: The animals were divided into three groups of 5 rabbits each; Group A (control), Group B (low dose) fed 4g/kg of MSG, and Group C (high dose) fed 6g/kg of MSG. One animal from each group was sacrificed at the end of 6th, 12th, 18th and 24th week. Thyroid glands were dissected and sections were stained with haematoxylin and eosin stain. These were examined under a compound microscope and images taken.
RESULTS: Histologically significant changes were observed in Group B and Group C. Follicular hyperplasia and hypertrophy was seen. The lining epithelium of the follicular cells became of the squamous type and follicles were filled with abundant colloid.
CONCLUSION: Oral administration of MSG has a profound impact on thyroid tissue integrity and function. Therefore, its use should be restricted as much as possible given its widespread cytotoxic effects on various organs of the body.
References
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Falak S. Pandit
Senior Resident, Department of Anatomy, Government Medical College, Srinagar, Kashmir
Mohammad S. Itoo
Professor, Department of Anatomy, Government Medical College, Srinagar, Kashmir, India
Nazish A. Chisti
Senior Resident, Department of Anatomy, Government Medical College, Srinagar, Kashmir
Ghulam M. Bhat
Head of Department, Anatomy, Government Medical College, Srinagar, Kashmir, India
Lateef A. Wani
Professor, Department of Pathology, Government Medical College, Srinagar, Kashmir, India