TOURAINE-SOLENTE-GOLÉ SYNDROME: AN UNUSUAL CASE OF DIGITAL CLUBBING AND HYPERHIDROSIS IN A TEENAGER.

Abstract

Primary hypertrophic osteoarthropathy (PHO), characterised by digital clubbing, periostosis, pachydermia, and hyperhidrosis, is also known as pachydermoperiostosis (PDP). It is a rare genetic condition with three clinical presentations. Here, we describe a 14-year-old boy presenting with recurrent episodes of arthralgia, profuse perspiration, and increasing swelling of his fingers and toes. On examination, all digits exhibited grade 4 clubbing, hyperhidrosis, and anemia. Secondary causes of clubbing and hyperhidrosis were excluded. Although the clinical characteristics met the requirements for PDP, genetic testing was not carried out because of monetary limitations. Male preponderance and varying inheritance patterns characterize PDP, which usually first appears in adolescence, develops over ten years, and stabilizes. Thyroid acropathy and acromegaly are few of many differential diagnoses. This instance emphasizes how critical it is to conduct a comprehensive assessment and identify PDP early, especially in situations when genetic testing is not available.