MANAGEMENT OF VENPULLI (VITILIGO) WITH SIDDHA FORMULATION PAPPULAARISHTAM - A CASE REPORT
Main Article Content
Keywords
Venpulli, Pappulaarishtam, Siddha formulation,VASI Score, Repigmentation.
Abstract
Vitiligo or Venpulli, is depigmented disorder that results in the formation of white patches on the skin due to the loss of melanocytes. This case report explores the efficacy of Pappulaarishtam, a Siddha herbal formulation, in the management of vitiligo.
Objective: This case report aims to evaluate the effectiveness of Pappulaarishtam, a Siddha herbal formulation, in treating vitiligo (Venpulli) focusing on clinical outcomes like repigmentation, adverse effects and exploring its potential as a complementary therapy.
Methodology: A 35-year-old male patient diagnosed with venpulli was administered Pappulaarishtam, a Siddha herbal formulation for six months. The patient was monitored for clinical improvements, repigmentation and VASI Score was recorded for prognosis. Regular follow-up visits were conducted to assess treatment progress.
Result: Significant repigmentation was observed in the affected areas of the skin after three months of treatment with Pappulaarishtam.
Conclusion: Pappulaarishtam shows promising results as an effective and safe alternative treatment for vitiligo, warranting further clinical investigation.
References
2. Thiyagarajan R. Siddha Maruthuvam Sirappu. First ed. Commisionerate of Indian Medicine and Homoeopathy; 2013. Chapter 4, Thorpinigal; p.233,234,237.
3. Jimbow K, Kato T. Vitiligo: A Comprehensive Textbook of Dermatology. 1st ed. Berlin: Springer; 2014. p. [132-140].
4. Taïeb A, Picardo M. Vitiligo: A Monograph on the Basic and Clinical Science. Berlin: Springer; mber] 2009. P.189-195
5. Mahajan VK, Vashist S, Chauhan PS, Mehta KIS, Sharma V, Sharma A. ClinicoEpidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India. Indian Dermatol Online J. 2019 JanFeb;10(1):38 44. doi: 10.4103/idoj.IDOJ_124_18. PMID: 30775297; PMCID: PMC6362747. https://pubmed.ncbi.nlm.nih.gov/30775297/
6. Jat, Yashdeep & Varma, Krishnendra & Kumar, Ujjwal & Mahadik, Aishwarya. (2022). An observational study of Vitiligo. IP Indian Journal of Clinical and Experimental Dermatology. 8. 39-42.
7. Anbarasu K. Yugi vaithya sinthamani, 3rd ed. Thaamarai noolagam; 2018 chapter 12, Kuttarogam, pg-190-200.
8. K.N.Kuppusami Mudhaliar, Siddha vaithiya thirratu,edition 4th ;1998,Indian Medicine and Homeopathy, 168-173.
9. Hu W, Xu Y, Ma Y, Lei J, Lin F, Xu AE. Efficacy of the topical calcineurin inhibitors tacrolimus and pimecrolimus in the treatment of vitiligo in infants under 2 years of age: A randomized, open-label pilot study. Clin Drug Investig. 2019 Dec;39(12):1233–1238. doi:10.1007/s40261-019-00845-x. PMID: 31522334. Available from: https://pubmed.ncbi.nlm.nih.gov/31522334/
10. Wooltorton E. Eczema drugs tacrolimus (Protopic) and pimecrolimus (Elidel): cancer concerns. CMAJ. 2005 Apr 26;172(9):1179–1180. doi:10.1503/cmaj.050373. Epub 2005 Apr 7. PMID: 15817641; PMCID: PMC557066. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC557066/
11. Zou Q, Huang Y, Zhang W, Lu C, Yuan J. A Comprehensive Review of the Pharmacology, Chemistry, Traditional Uses and Quality Control of Star Anise (Illicium verum Hook. F.): An Aromatic Medicinal Plant. Molecules. 2023 Nov 1;28(21):7378. doi: 10.3390/molecules28217378. PMID: 37959797; PMCID: PMC10648513.
12. Wahidah H. Al-Qahtani, Yuvaraj Dinakarkumar, Selvaraj Arokiyaraj, Vigneshwar Saravanakumar, Jothi Ramalingam Rajabathar, Kowsalya Arjun, P.K. Gayathri, Jimmy Nelson Appaturi,Phyto-chemical and biological activity of Myristica fragrans, an ayurvedic medicinal plant in Southern India and its ingredient analysis,Saudi Journal of Biological Sciences,Volume 29, Issue 5,2022,Pages 3815-3821,ISSN 1319-562X,https://doi.org/10.1016/j.sjbs.2022.02.043.(https://www.sciencedirect.com/science/article/pii/S1319562X2200119X)
13. Pagliari S, Forcella M, Lonati E, Sacco G, Romaniello F, Rovellini P, Fusi P, Palestini P, Campone L, Labra M, Bulbarelli A, Bruni I. Antioxidant and Anti-Inflammatory Effect of Cinnamon (Cinnamomum verum J. Presl) Bark Extract after In Vitro Digestion Simulation. Foods. 2023 Jan 18;12(3):452. doi: 10.3390/foods12030452. PMID: 36765979; PMCID: PMC9914695.
14. Batiha GE, Alkazmi LM, Wasef LG, Beshbishy AM, Nadwa EH, Rashwan EK. Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities. Biomolecules. 2020 Jan 30;10(2):202. doi: 10.3390/biom10020202. PMID: 32019140; PMCID: PMC7072209.
15. Rahman MM, Soma MA, Sultana N, Hossain MJ, Sufian MA, Rahman MO, Rashid MA. Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti-inflammatory, analgesic, and antidiarrheal properties. Health Sci Rep. 2023 Oct 25;6(10):e1654. doi: 10.1002/hsr2.1654. PMID: 37885464; PMCID: PMC10599101.
16. Rajeshwari M. Understanding the concept of purgation in Siddha medicine: A review. Int J Ayurveda Pharma Res. 2022 Jun;10(6). Available from: https://www.researchgate.net/publication/362228998_Understanding_the_Concept_of_Purgation_in_Siddha_Medicine_A_Review
17. Diptimayee Jena, D Prasanth, Asra Jabeen, Subhashree Sahoo, Pratishya Bhatta, Aakansha Jeeya, Kirtimaya Mishra. An overview of Prosopis Juliflora's pharmacologic aspects. Int J Pharmacognosy Life Sci 2023;4(1):121-126. DOI: 10.33545/27072827.2023.v4.i1b.83
18. BAUHINIA TOMENTOSA: A PHYTOPHARMACOLOGICAL REVIEW. (2011). International Research Journal of Pharmacy, 2(12), 120-123. https://irjponline.org/index.php/irjp/article/view/3010
19. Yadav V, Krishnan A, Vohora D. A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacology. 2020 Jan 30;247:112255. doi: 10.1016/j.jep.2019.112255. Epub 2019 Sep 27. PMID: 31568819.
20. Chitra SM. In Silico Analysis of Siddha Formulation Thippili Rasayanam Against COVID- 19 in Inhibition of Ribonucleic Acid-Dependent Ribonucleic Acid Polymerase Target Enzyme. Indian Journal of Pharmaceutical Sciences. 2024 Jan 1;86(1).
21. Shanmugavelu M. Noi naadal noi muthal naadal thirattu, 6th edition Vol -1: Department of Indian medicine and Homoeopathy; 2014: Pg 363.
22. Shanmugavelu M. Noi naadal noi muthal naadal thirattu, 6th edition Vol -1: Department of Indian medicine and Homoeopathy; 2014: Pg 363.
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S. Malini
PG Scholar, Department of PG Noinaadal, Government Siddha Medical College, Chennai106, Tamil Nadu, India.
K. Ellora
PG Scholar, Department of PG Noinaadal, Government Siddha Medical College, Chennai106, Tamil Nadu, India.
S.M. Chitra
Lecturer, Department of PG Noinaadal, Government Siddha Medical College, Chennai106, Tamil Nadu, India
M. Muthukumaran
Head of the Department, Department of PG Noinaadal, Government Siddha Medical College, Chennai106, Tamil Nadu, India