THE IMPACT OF AEROBIC EXERCISE ON DEPRESSION, ANXIETY, AND STRESS IN PATIENTS WITH CHRONIC RENAL DISEASE- A RANDOMIZED CONTROLLED TRIAL
Main Article Content
Keywords
aerobic exercise, chronic kidney disease, CKD, Depression, Anxiety
Abstract
Background and objectives
Chronic kidney disease (CKD) is a worldwide health issue, and its prevention necessitates the adoption of a healthy lifestyle. Recent studies have endorsed low-intensity exercise for patients with renal disease; however, maintaining a healthy lifestyle remains essential for treating chronic kidney disease. Method: The study investigates the effects of therapeutic aerobic exercise on 150 subjects with chronic renal disease, dividing the patients into two groups: a control group and an intervention group. The intervention group received a six-month aerobic exercise regimen alongside conventional therapy, while the control group received conventional care. Results: The study found that aerobic exercises can improve depression, anxiety, and stress. Conclusion: Aerobic exercise has been shown to improve depression, anxiety, and stress levels in individuals with CKD, but it is crucial to consider the patient's condition and disease stage when recommending fitness regimens.
References
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24. Abd-Elmonem AM, Al-Tohamy AM, Galal REE, Abd-Elhalim FA. Effects of progressive resistance exercises on quality of life and functional capacity in pediatric patients with chronic kidney disease: a randomized trail. J Musculoskelet Neuronal Interact. 2019;19(2):187–95.
25. Ribeiro R, Coutinho GL, Iuras A, Barbosa AM, Souza JAC de, Diniz DP, et al. Effect of resistance exercise intradialytic in renal patients chronic in hemodialysis. J Bras Nefrol. 2013;35(1):13–9.
26. Koehl M, Meerlo P, Gonzales D, Rontal A, Turek FW, Abrous DN. Exercise-induced promotion of hippocampal cell proliferation requires beta-endorphin. FASEB J Off Publ Fed Am Soc Exp Biol. 2008 Jul;22(7):2253–62.
27. Hegadoren KM, O’Donnell T, Lanius R, Coupland NJ, Lacaze-Masmonteil N. The role of beta-endorphin in the pathophysiology of major depression. Neuropeptides. 2009 Oct;43(5):341–53.
28. Krogh J, Nordentoft M, Mohammad-Nezhad M, Westrin A. Growth hormone, prolactin and cortisol response to exercise in patients with depression. J Affect Disord. 2010 Sep;125(1–3):189–97.
29. M A. Physical Activity is a Necessary Part of Care in Patients with Chronic Kidney Disease - Short Historical Overview. Prim Health Care Open Access [Internet]. 2017 [cited 2023 Jul 5];07(02). Available from: https://www.omicsgroup.org/journals/physical-activity-is-a-necessary-part-of-care-in-patients-with-chronickidney-disease--short-historical-overview-2167-1079-1000271.php?aid=90526
2. Harambat J, Madden I. What is the true burden of chronic kidney disease in children worldwide? Pediatr Nephrol. 2023 May;38(5):1389–93.
3. Kumar S, Joshi R, Joge V. Do clinical symptoms and signs predict reduced renal function among hospitalized adults? Ann Med Health Sci Res. 2013;3(4):492.
4. Thurlow JS, Joshi M, Yan G, Norris KC, Agodoa LY, Yuan CM, Nee R. Global Epidemiology of End-Stage Kidney Disease and Disparities in Kidney Replacement Therapy. Am J Nephrol. 2021;52(2):98-107. doi: 10.1159/000514550. Epub 2021 Mar 22. PMID: 33752206; PMCID: PMC8057343.
5. Pallone JM, Santos DGMD, Oliveira Dias AL, Ferreira LGS, Costa da Silva C, Orlandi FS. Loneliness Level and Its Associated Factors in Patients With Hemodialysis. Clin Nurs Res. 2022 Jul;31(6):1164-1171. doi: 10.1177/10547738211061447. Epub 2021 Dec 26. PMID: 34955033.
6. Hmwe NTT, Subramanian P, Tan LP, Chong WK. The effects of acupressure on depression, anxiety and stress in patients with hemodialysis: a randomized controlled trial. Int J Nurs Stud. 2015 Feb;52(2):509–18.
7. Vaziri ND. Gut microbial translocation in the pathogenesis of systemic inflammation in patients with end-stage renal disease. Dig Dis Sci. 2014 Sep;59(9):2020–2.
8. Esgalhado M, Stockler-Pinto MB, de França Cardozo LFM, Costa C, Barboza JE, Mafra D. Effect of acute intradialytic strength physical exercise on oxidative stress and inflammatory responses in hemodialysis patients. Kidney Res Clin Pract. 2015 Mar;34(1):35–40.
9. Seong EY. Acute intradialytic exercise and oxidative stress in hemodialysis patients. Kidney Res Clin Pract. 2015 Mar;34(1):1–3.
10. Heiwe S, Jacobson SH. Exercise training in adults with CKD: a systematic review and meta-analysis. Am J Kidney Dis Off J Natl Kidney Found. 2014 Sep;64(3):383–93.
11. Mafra D, Fouque D. Lower physical activity and depression are associated with hospitalization and shorter survival in CKD. Clin J Am Soc Nephrol CJASN. 2014 Oct 7;9(10):1669–70.
12. Kimmel PL, Peterson RA. Depression in end-stage renal disease patients treated with hemodialysis: tools, correlates, outcomes, and needs. Semin Dial. 2005;18(2):91–7.
13. Lopes AA, Bragg J, Young E, Goodkin D, Mapes D, Combe C, et al. Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney Int. 2002 Jul;62(1):199–207.
14. Drayer RA, Piraino B, Reynolds CF, Houck PR, Mazumdar S, Bernardini J, et al. Characteristics of depression in hemodialysis patients: symptoms, quality of life and mortality risk. Gen Hosp Psychiatry. 2006;28(4):306–12.
15. Lee M, Choi H, Shin J, Suh HS. The Effects of Adding Art Therapy to Ongoing Antidepressant Treatment in Moderate-to-Severe Major Depressive Disorder: A Randomized Controlled Study. Int J Environ Res Public Health. 2022 Dec 21;20(1):91. doi: 10.3390/ijerph20010091. PMID: 36612412; PMCID: PMC9819126.
16. Ashby D, Borman N, Burton J, Corbett R, Davenport A, Farrington K, Flowers K, Fotheringham J, Andrea Fox RN, Franklin G, Gardiner C, Martin Gerrish RN, Greenwood S, Hothi D, Khares A, Koufaki P, Levy J, Lindley E, Macdonald J, Mafrici B, Mooney A, Tattersall J, Tyerman K, Villar E, Wilkie M. Renal Association Clinical Practice Guideline on Haemodialysis. BMC Nephrol. 2019 Oct 17;20(1):379. doi: 10.1186/s12882-019-1527-3. PMID: 31623578; PMCID: PMC6798406.
17. Dai D, Sharma A, Alvarez PJ, Woods SD. Multiple comorbid conditions and healthcare resource utilization among adult patients with hyperkalemia: A retrospective observational cohort study using association rule mining. J Multimorb Comorbidity. 2022 Jan;12:263355652210988.
18. Schrauben SJ, Apple BJ, Chang AR. Modifiable Lifestyle Behaviors and CKD Progression: A Narrative Review. Kidney360. 2022 Apr 28;3(4):752–78.
19. Yu H, Huang M, Tao Y, Li S, Wang J, Li P, Lv H, Ni C. The effects of exercise training interventions on depression in hemodialysis patients. Front Psychiatry. 2024 Jan 8;14:1321413. doi: 10.3389/fpsyt.2023.1321413. PMID: 38260806; PMCID: PMC10800967.
20. Oei TP, Sawang S, Goh YW, Mukhtar F. Using the Depression Anxiety Stress Scale 21 (DASS-21) across cultures. Int J Psychol. 2013;48(6):1018-29.
21. Kouidi E, Iacovides A, Iordanidis P, Vassiliou S, Deligiannis A, Ierodiakonou C, Tourkantonis A. Exercise renal rehabilitation program: psychosocial effects. Nephron. 1997;77(2):152-8. doi: 10.1159/000190266. PMID: 9346380.
22. Evaluation of a pragmatic exercise rehabilitation programme in chronic kidney disease | Nephrology Dialysis Transplantation | Oxford Academic [Internet]. [cited 2024 Aug 4]. Available from: https://academic.oup.com/ndt/article/27/suppl_3/iii126/1823314
23. Levendoğlu F, Altintepe L, Okudan N, Uğurlu H, Gökbel H, Tonbul Z, et al. A twelve week exercise program improves the psychological status, quality of life and work capacity in hemodialysis patients. J Nephrol. 2004;17(6):826–32.
24. Abd-Elmonem AM, Al-Tohamy AM, Galal REE, Abd-Elhalim FA. Effects of progressive resistance exercises on quality of life and functional capacity in pediatric patients with chronic kidney disease: a randomized trail. J Musculoskelet Neuronal Interact. 2019;19(2):187–95.
25. Ribeiro R, Coutinho GL, Iuras A, Barbosa AM, Souza JAC de, Diniz DP, et al. Effect of resistance exercise intradialytic in renal patients chronic in hemodialysis. J Bras Nefrol. 2013;35(1):13–9.
26. Koehl M, Meerlo P, Gonzales D, Rontal A, Turek FW, Abrous DN. Exercise-induced promotion of hippocampal cell proliferation requires beta-endorphin. FASEB J Off Publ Fed Am Soc Exp Biol. 2008 Jul;22(7):2253–62.
27. Hegadoren KM, O’Donnell T, Lanius R, Coupland NJ, Lacaze-Masmonteil N. The role of beta-endorphin in the pathophysiology of major depression. Neuropeptides. 2009 Oct;43(5):341–53.
28. Krogh J, Nordentoft M, Mohammad-Nezhad M, Westrin A. Growth hormone, prolactin and cortisol response to exercise in patients with depression. J Affect Disord. 2010 Sep;125(1–3):189–97.
29. M A. Physical Activity is a Necessary Part of Care in Patients with Chronic Kidney Disease - Short Historical Overview. Prim Health Care Open Access [Internet]. 2017 [cited 2023 Jul 5];07(02). Available from: https://www.omicsgroup.org/journals/physical-activity-is-a-necessary-part-of-care-in-patients-with-chronickidney-disease--short-historical-overview-2167-1079-1000271.php?aid=90526
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Published
Aug 12, 2025
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Dr Alok Kumar Yadav, & Dr. Tripti Shrivastava. (2025). THE IMPACT OF AEROBIC EXERCISE ON DEPRESSION, ANXIETY, AND STRESS IN PATIENTS WITH CHRONIC RENAL DISEASE- A RANDOMIZED CONTROLLED TRIAL. Journal of Population Therapeutics and Clinical Pharmacology, 32(7), 403-409. https://doi.org/10.53555/xcfchx16
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Author Biographies
Dr Alok Kumar Yadav
Associate professor, Department of Physiology, Dr Ulhas Patil Medical College and Hospital, Jalgaon-425309, Maharashtra, India
Dr. Tripti Shrivastava
Professor, Department of Physiology, Datta Meghe Institute of Higher Education & Research, Sawangi (Meghe), Wardha-442107, Maharashtra, India
How to Cite
Dr Alok Kumar Yadav, & Dr. Tripti Shrivastava. (2025). THE IMPACT OF AEROBIC EXERCISE ON DEPRESSION, ANXIETY, AND STRESS IN PATIENTS WITH CHRONIC RENAL DISEASE- A RANDOMIZED CONTROLLED TRIAL. Journal of Population Therapeutics and Clinical Pharmacology, 32(7), 403-409. https://doi.org/10.53555/xcfchx16