“CLINICAL PROFILE OF THALASSEMIA, IRON DEFICIENCY ANEMIA, G6PD DEFICIENCY ANEMIA, LYMPHOMA AND LEUKEMIA IN KHYBER PAKHTUNKHWA PAKISTAN”
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Keywords
Anemia, IDA, Thalassemia, Leukemia, G6PD Deficiency Anemia
Abstract
Background: In Khyber Pakhtunkhwa (KP), Pakistan, anemia and hematologic malignancies are major challenges of the KP steady public health since there are limitations in genetic, dietary, socioeconomic, and diagnosis issues. Such conditions as Thalassemia, Iron Deficiency Anemia (IDA), G6PD Deficiency, Leukemia and Lymphoma.
Objective: To assess the clinical, demographic and diagnostic characteristics of five major hematologic disorders in KP.
Methods: The descriptive cross-sectional study was conducted at the Lady Reading Hospital Department of Hematology in Peshawar from January to June 2025. After ethical approval, non-probability sequential sampling selected 200 patient records. Demographics, symptoms at presentation, study tests (CBC, peripheral smear, electrophoresis, ferritin, G6PD analysis, bone marrow biopsy), and family history were acquired from hospital records and laboratory databases. Descriptive analysis was done in R (4.2.3).
Results: The most affected occupational groups were the students, housewives and tailors. Thalassemia and G6PD Deficiency were highly familiarly associated. Geographic concentration in Kohat, Mansehra and Swabi was reported in IDA and Leukemia. Gender distribution indicated that Thalassemia is common in females whereas Leukemia and IDA are common in males. The patterns of symptoms depended on the diagnosis, but fatigue, bone pain and fever were prevalent symptoms. Thalassemia had the lowest level of hemoglobin whereas Leukemia cases had elevated levels of WBCs and reduced numbers of platelets.
Conclusion: Anemia and hematologic malignancies in KP are occupational, geographical, and gender-specific. Genetic disorders are strongly linked to family history. Even in low-income nations, diagnostic profiling can improve early diagnosis, community health, and health care planning.
References
2. Gelaw Y, Getaneh Z, Melku M. Anemia as a risk factor for tuberculosis : a systematic review and meta-analysis. 2021;1–15.
3. Aziz S, Id A, Abbasi Z, Shahid B, Moin G, Hambidge M, et al. Prevalence and determinants of anemia among women of reproductive age in Thatta Pakistan : Findings from a cross-sectional study. 2020;1–16. Available from: http://dx.doi.org/10.1371/journal.pone.0239320
4. Bhadra P, Deb A. A Review on Nutritional Anemia A Review on Nutritional Anemia. 2020;(September).
5. Gedfie S, Getawa S, Melku M. Prevalence and Associated Factors of Iron Deficiency and Iron Deficiency Anemia Among Under-5 Children : A Systematic Review and Meta-Analysis. 2022;
6. Abbas RS. Study the Incidence , Types of Anemia and Associated Risk Factors in Pregnant Women. 2020;(December).
7. Jeihooni AK, Hoshyar S, Harsini PA, Rakhshani T. The effect of nutrition education based on PRECEDE model on iron deficiency anemia among female students. BMC Womens Health [Internet]. 2021;1–9. Available from: https://doi.org/10.1186/s12905-021-01394-2
8. Qadir MA, Rashid N, Mengal MA, Hasni MS, Khan GM, Shawani NA, et al. Iron-Deficiency Anemia in Women of Reproductive Age in Urban Areas of Quetta District , Pakistan. 2022;2022.
9. Yu Z, Xiong Q, Wang Z, Li L. Global , regional , and national burden of glucose-6-phosphate dehydrogenase ( G6PD ) de fi ciency from 1990 to 2021 : a systematic analysis of the global burden of disease study 2021. 2025;(May):1–10.
10. Division M, Mahamoud NK, Mwambi B, Oyet C, Segujja F, Okiria JC, et al. Prevalence of Anemia and Its Associated Socio- Demographic Factors Among Pregnant Women Attending an Antenatal Care Clinic at Kisugu Prevalence of Anemia and Its Associated Socio-Demographic Factors Among Pregnant Women Attending an Antenatal Care Clinic at Kisugu Health Center IV , Makindye Division , Kampala , Uganda. 2020;2736.
11. Palaka E, Grandy S, Haalen H Van, Mcewan P, Darlington O. The Impact of CKD Anaemia on Patients : Incidence , Risk Factors , and Clinical Outcomes — A Systematic Literature Review. 2020;2020.
12. Musallam KM, Lombard L, Kistler KD, Zagadailov E, Gilroy KS, Taher AT, et al. Epidemiology of clinically significant forms of alpha- and beta- thalassemia : A global map of evidence and gaps. 2023;(June):1436–51.
13. Sarna A, Mps AP, Mph SR, Agrawal PK, Acharya R, Mph RJ, et al. Characterisation of the types of anaemia prevalent among children and adolescents aged 1 – 19 years in India : a population-based study. Lancet child Adolesc Heal [Internet]. 4(7):515–25. Available from: http://dx.doi.org/10.1016/S2352-4642(20)30094-8
14. Hassan Z, Ali I, Khan F. Glucose-6-phosphate Dehydrogenase Deficiency in Patients Attending Tertiary Care Health Setting in Peshawar. 2020;2:72–5.
15. Barton JC, Wiener HW, Barton JC, Acton RT. Prevalence of Iron Deficiency Using 3 Definitions Among Women in the US and Canada. 2024;7(6):1–12.
16. Shah N, Bhor M, Id LX, Paulose J, Yuce H. Sickle cell disease complications : Prevalence and resource utilization. 2019;2–13.
17. Abbas M, Muhammad B, Ali A, Gul M, Malook A. Outcome of Iron Deficiency Anemia in patients presenting with Breath Holding Spellsat Lady Reading Hospital Peshawar. 2023;17(8):15–8.
18. Ujjan JA, Unar K. To Find Out The Prevalence Of Thalassaemia In Sukkur Pakistan. 2023;(July).
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Tufeel Ahmad
(Sub Inspector Emergency Rescue Services 1122, Peshawar)
Abdullah Shah
(Medical Receptionist at Aga Khan Hospital Laboratory)
Riaz khan Dawar
(Senior lecturer at sarhad University Peshawar)
Romaisa Siddique
(BS- Medical lab Technology, Sarhad University Peshawar, Pakistan)
Sher Alam
(Lab Technologist at Khair Ul Nas Medical Laboratory Bara)
Dr. Ali Man shah
Assistant professor Sarhad University Information Technology Peshawar, Pakistan
Kaleem Ullah Ullah
(Senior Lecturer at Sarhad University Peshawar Pakistan)
Wahid Ullah
(Assistant Professor at Sarhad University Peshawar, Pakistan)