Role of vitamin B3 in the prevention of acute kidney injury post-cardiac surgery through measurement of serum Cystatin C and Creatinine

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Wallaa Luay Alfalluji
Ghazwan Talal Mahdi
Ahmed Ammar
Mohammed Shuailah
Mayssa Jalal Majeed


vitamin, kidney, role, measurement.


Background—Acute kidney injury is a risk factor for mortality in cardiac surgery patients. Nicotinamide adenine dinucleotide (NAD+) is a cofactor for numerous enzymes involved in cellular energy metabolism, and for adaptive responses of cells to bioenergetics and oxidative stress and is now a major player in aging and age-related diseases. Plasma cystatin C and creatinine have an important role in the early diagnosis of renal injury post-cardiac surgery.
Method: Using cohort - study design based on 90 subjects all patients subjected to open-heart surgery, were divided into two groups according to the dosing of niacin (vitamin B3) we measured serum cystatin C and creatinine basal level, one day before surgery, one day after surgery and after 7 days after surgery.
Results: Serum cystatin C level and creatinine significantly elevated (p≤0.05) in the second group (control group) (subjects who didn´t receive vitamin B3 supplement from baseline while those who receive vitamin B3 supplement show stable serum cystatin C and creatinine level.
Conclusion: vitamin B3 (niacin) has a beneficial role in renal protection after cardiac surgery.

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