Mean Ocular Perfusion Pressures Circadian Fluctuation and Its Relationship with different types of Glaucoma
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Abstract
Purpose: This study investigates the circadian fluctuation of mean ocular perfusion pressure (MOPP) and its association with different types of glaucoma, aiming to determine its role in disease pathophysiology and progression.
References
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2. Berisha, F., Hoffmann, E. M., & Pfeiffer, N. (2016). Retinal blood flow in glaucoma. Current Opinion in Ophthalmology, 27(2), 124–131.
3. Bowe, A., Grünig, M., Schubert, J., & Schilling, M. (2011). Circadian fluctuation of ocular perfusion pressure in glaucoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology, 249(8), 1163–1168.
4. Caprioli, J., & Coleman, A. L. (2010). Blood pressure, perfusion pressure, and glaucoma. Current Opinion in Ophthalmology, 21(2), 80–85.
5. Charlson, M. E., de Moraes, C. G., Link, A., Wells, M. T., Harmon, G., & Ritch, R. (2014). Nocturnal systemic hypotension increases the risk of glaucoma progression. Ophthalmology, 121(10), 2004–2012.
6. Choi, J., & Kook, M. S. (2015). Systemic hypotension and nighttime blood pressure reduction are associated with progression of normal-tension glaucoma. Ophthalmology, 122(6), 1093–1101.
7. Costa, V. P., Harris, A., Anderson, D., Stodtmeister, R., Cremasco, F., & Kergoat, H. (2014). Ocular perfusion pressure in glaucoma. Acta Ophthalmologica, 92(4), e252–e266.
8. Flammer, J., & Mozaffarieh, M. (2008). What is the present pathogenetic concept of glaucomatous optic neuropathy? Survey of Ophthalmology, 53(Suppl 1), S162–S173.
9. Gherghel, D., Orgul, S., Gugleta, K., Gekkieva, M., & Flammer, J. (2004). Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage. American Journal of Ophthalmology, 138(5), 744–750.
10. Grieshaber, M. C., Flammer, J., & Orgul, S. (2007). Relationship between ocular blood flow and glaucoma. Current Opinion in Ophthalmology, 18(2), 100–105.
11. Kaiser, H. J., Flammer, J., Wenk, M., & Lütscher, T. F. (2013). Endothelin-1 plasma levels in normal-tension glaucoma: abnormal circadian rhythm. Graefe's Archive for Clinical and Experimental Ophthalmology, 231(8), 613–618.
12. Leske, M. C., Heijl, A., Hyman, L., Bengtsson, B., & Komaroff, E. (2008). Factors for glaucoma progression and the effect of treatment: the Early Manifest Glaucoma Trial. Archives of Ophthalmology, 126(3), 378–385.
13. Liu, J. H. K., Zhang, X., Kripke, D. F., & Weinreb, R. N. (2003). Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Investigative Ophthalmology & Visual Science, 44(4), 1586–1590.
14. Quaranta, L., Katsanos, A., Russo, A., & Riva, I. (2016). 24-hour intraocular pressure and ocular perfusion pressure in glaucoma. Survey of Ophthalmology, 61(1), 26–41.
2. Berisha, F., Hoffmann, E. M., & Pfeiffer, N. (2016). Retinal blood flow in glaucoma. Current Opinion in Ophthalmology, 27(2), 124–131.
3. Bowe, A., Grünig, M., Schubert, J., & Schilling, M. (2011). Circadian fluctuation of ocular perfusion pressure in glaucoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology, 249(8), 1163–1168.
4. Caprioli, J., & Coleman, A. L. (2010). Blood pressure, perfusion pressure, and glaucoma. Current Opinion in Ophthalmology, 21(2), 80–85.
5. Charlson, M. E., de Moraes, C. G., Link, A., Wells, M. T., Harmon, G., & Ritch, R. (2014). Nocturnal systemic hypotension increases the risk of glaucoma progression. Ophthalmology, 121(10), 2004–2012.
6. Choi, J., & Kook, M. S. (2015). Systemic hypotension and nighttime blood pressure reduction are associated with progression of normal-tension glaucoma. Ophthalmology, 122(6), 1093–1101.
7. Costa, V. P., Harris, A., Anderson, D., Stodtmeister, R., Cremasco, F., & Kergoat, H. (2014). Ocular perfusion pressure in glaucoma. Acta Ophthalmologica, 92(4), e252–e266.
8. Flammer, J., & Mozaffarieh, M. (2008). What is the present pathogenetic concept of glaucomatous optic neuropathy? Survey of Ophthalmology, 53(Suppl 1), S162–S173.
9. Gherghel, D., Orgul, S., Gugleta, K., Gekkieva, M., & Flammer, J. (2004). Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage. American Journal of Ophthalmology, 138(5), 744–750.
10. Grieshaber, M. C., Flammer, J., & Orgul, S. (2007). Relationship between ocular blood flow and glaucoma. Current Opinion in Ophthalmology, 18(2), 100–105.
11. Kaiser, H. J., Flammer, J., Wenk, M., & Lütscher, T. F. (2013). Endothelin-1 plasma levels in normal-tension glaucoma: abnormal circadian rhythm. Graefe's Archive for Clinical and Experimental Ophthalmology, 231(8), 613–618.
12. Leske, M. C., Heijl, A., Hyman, L., Bengtsson, B., & Komaroff, E. (2008). Factors for glaucoma progression and the effect of treatment: the Early Manifest Glaucoma Trial. Archives of Ophthalmology, 126(3), 378–385.
13. Liu, J. H. K., Zhang, X., Kripke, D. F., & Weinreb, R. N. (2003). Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Investigative Ophthalmology & Visual Science, 44(4), 1586–1590.
14. Quaranta, L., Katsanos, A., Russo, A., & Riva, I. (2016). 24-hour intraocular pressure and ocular perfusion pressure in glaucoma. Survey of Ophthalmology, 61(1), 26–41.
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Published
Jul 25, 2025
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How to Cite
Palaboina Rupanjali Yadav, & Narayan.M. (2025). Mean Ocular Perfusion Pressures Circadian Fluctuation and Its Relationship with different types of Glaucoma. Journal of Population Therapeutics and Clinical Pharmacology, 32(6), 1219-1228. https://doi.org/10.53555/m41tp569
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Author Biographies
Palaboina Rupanjali Yadav
Post Graduate Student, Department of Ophthalmology, PESIMSR, Kuppam
Narayan.M
HOD, Department of Ophthalmology, PESIMSR, Kuppam
How to Cite
Palaboina Rupanjali Yadav, & Narayan.M. (2025). Mean Ocular Perfusion Pressures Circadian Fluctuation and Its Relationship with different types of Glaucoma. Journal of Population Therapeutics and Clinical Pharmacology, 32(6), 1219-1228. https://doi.org/10.53555/m41tp569