FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL ANTIFUNGAL POLYMERIC FILM
Main Article Content
Keywords
Polymeric film, Transdermal drug delivery system, Fungal infection, Luliconazole, Antifungal
Abstract
Polymeric films are thin, flexible layers made of natural or synthetic polymers used in drug delivery, packaging, and biomedical applications. They offer advantages such as controlled drug release, ease of administration, and improved patient compliance. Most research on luliconazole focuses on topical or nano-based delivery, but a transdermal film is a relatively unexplored yet promising approach. This project bridges a gap in dermatological drug delivery, making it a novel and impactful study. Unique Drug Delivery Approach Transdermal films for antifungal drugs are not extensively explored, especially for luliconazole, which is conventionally used in topical creams, gels, or solutions. A polymeric film formulation could enhance patient compliance, reduce systemic side effects, and provide controlled drug release Luliconazole is a potent imidazole antifungal with broad-spectrum activity, but its transdermal delivery has not been widely studied. Developing a film formulation could improve its skin penetration, stability, and efficacy compared to conventional dosage forms.
References
1. Kullar R, Saini S, Steth N, Rana AC. Emulgel a surrogate approach for topical used hydrophobic drugs. Int J Pharm Biol Sci 2011; 1:117-28.
2. Single V, Saini S, Joshi B, Rana AC. Emulgel: a new platform for topical drug delivery. Int J Pharm Biol Sci 2012; 3:485-98.
3. Cilurzo, F., Cupone, I. E., Minghetti, P., et al. (2008). Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 70(3), 895–900.
4. Shilakari. G, (2013) Novel vesicular carriers for topical drug delivery and their application; International Journal of Pharmaceutical Sciences Review and Research 21,14,77-86
5. Ei-Badry, M., Hassan, M. A., Ibrahim, M. A., and Elsaghir, H. (2013). Performance of poloxamer 407 as hydrophilic carrier on the binary mixtures with nimesulide. Farmacia.
6. Ravikumar, A.A.; Kulkarni, P.K.; Osmani, R.A.M.; Hani, U.; Ghazwani, M.; Fatease, A.A.; Alamri, A.H.; Gowda, D.V. (2022) Carvedilol, Precipitation Inhibition by the Incorporation of polymeric precipitation inhibitors using a stable amorphous solid dispersion, approach: formulation, characterization and in vitro in vivo evaluation. polymers,14,4977
7. Anter, H.M, Abu Hashim, I.I.; Awadin, W.; Meshali, M.M. (2019). Novel Chitosan Oligosaccharide based Nanoparticles for Gastric Mucosal Administration of the phytochemical “Apocynin”. int.J. Nanomed.14,4911-4929
8. Shinde, C.G, Venkatesh, M.P.; Rajesh, K.S.; Srivastava, A.; Osmani, R.A.; Sonawane, Y.H. (2016). Intra-articular delivery of a methotrexate loaded nanostructured lipid carrier based smart gel for effective treatment of rheumatic diseases. RSC Adv,6,12913-12924
9. Dasgupta S, K Ghosh S, Ray S, Mazumder B. Solid lipid nanoparticles (SLNs) gels for topical delivery of aceclofenac in vitro and in vivo evaluation. Current drug delivery. 2013 Dec 1;10(6):656-66.
10. Patel, S., et al. (2020). "Transdermal drug delivery systems: A review." International Journal of Pharmaceutical Sciences
11. Khanna, D., and S. Bharti. "Luliconazole for the treatment of fungal infections: An evidence-based review. Core Evid. 2014; 9: 113–24.
12. World Health Organization. (2022). "Global trends in fungal infections."
13. El-Housiny, Shaimaa, et al. "Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study." Drug delivery 25.1 (2018): 78-90.
14. Shah, M., et al. "Solid lipid nanoparticles of a water-soluble drug, ciprofloxacin hydrochloride." Indian journal of pharmaceutical sciences 74.5 (2012): 434.
15. Desai, Noopur J., and Dilip G. Maheshwari. "UV spectrophotometric method for the estimation of luliconazole in marketed formulation (lotion)." Pharma Science Monitor 5.2 (2014): 48-54.
16. El-Housiny, Shaimaa, et al. "Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study." Drug delivery 25.1 (2018): 78-90
17. Bräm S, Wolfram E, Recent Advances in Effect-directed Enzyme Assays based on thin layer Chromatography, Phytochemical Analysis, 2017; 28(2): 74-86.
18. Uprit, Shubham, et al. "Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia." Saudi Pharmaceutical Journal 21.4 (2013): 379-385.
19. Pawar PM, Solanki KP, Mandali VA. Recent Advancements in Transdermal Drug Delivery System. International Journal of Pharmaceutical and Clinical Research. 2018;10(3):65-73.
20. Foldvari M, Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharmaceutical science & technology today. 2000 Dec 1;3(12):417-25.
2. Single V, Saini S, Joshi B, Rana AC. Emulgel: a new platform for topical drug delivery. Int J Pharm Biol Sci 2012; 3:485-98.
3. Cilurzo, F., Cupone, I. E., Minghetti, P., et al. (2008). Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics, 70(3), 895–900.
4. Shilakari. G, (2013) Novel vesicular carriers for topical drug delivery and their application; International Journal of Pharmaceutical Sciences Review and Research 21,14,77-86
5. Ei-Badry, M., Hassan, M. A., Ibrahim, M. A., and Elsaghir, H. (2013). Performance of poloxamer 407 as hydrophilic carrier on the binary mixtures with nimesulide. Farmacia.
6. Ravikumar, A.A.; Kulkarni, P.K.; Osmani, R.A.M.; Hani, U.; Ghazwani, M.; Fatease, A.A.; Alamri, A.H.; Gowda, D.V. (2022) Carvedilol, Precipitation Inhibition by the Incorporation of polymeric precipitation inhibitors using a stable amorphous solid dispersion, approach: formulation, characterization and in vitro in vivo evaluation. polymers,14,4977
7. Anter, H.M, Abu Hashim, I.I.; Awadin, W.; Meshali, M.M. (2019). Novel Chitosan Oligosaccharide based Nanoparticles for Gastric Mucosal Administration of the phytochemical “Apocynin”. int.J. Nanomed.14,4911-4929
8. Shinde, C.G, Venkatesh, M.P.; Rajesh, K.S.; Srivastava, A.; Osmani, R.A.; Sonawane, Y.H. (2016). Intra-articular delivery of a methotrexate loaded nanostructured lipid carrier based smart gel for effective treatment of rheumatic diseases. RSC Adv,6,12913-12924
9. Dasgupta S, K Ghosh S, Ray S, Mazumder B. Solid lipid nanoparticles (SLNs) gels for topical delivery of aceclofenac in vitro and in vivo evaluation. Current drug delivery. 2013 Dec 1;10(6):656-66.
10. Patel, S., et al. (2020). "Transdermal drug delivery systems: A review." International Journal of Pharmaceutical Sciences
11. Khanna, D., and S. Bharti. "Luliconazole for the treatment of fungal infections: An evidence-based review. Core Evid. 2014; 9: 113–24.
12. World Health Organization. (2022). "Global trends in fungal infections."
13. El-Housiny, Shaimaa, et al. "Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study." Drug delivery 25.1 (2018): 78-90.
14. Shah, M., et al. "Solid lipid nanoparticles of a water-soluble drug, ciprofloxacin hydrochloride." Indian journal of pharmaceutical sciences 74.5 (2012): 434.
15. Desai, Noopur J., and Dilip G. Maheshwari. "UV spectrophotometric method for the estimation of luliconazole in marketed formulation (lotion)." Pharma Science Monitor 5.2 (2014): 48-54.
16. El-Housiny, Shaimaa, et al. "Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study." Drug delivery 25.1 (2018): 78-90
17. Bräm S, Wolfram E, Recent Advances in Effect-directed Enzyme Assays based on thin layer Chromatography, Phytochemical Analysis, 2017; 28(2): 74-86.
18. Uprit, Shubham, et al. "Preparation and characterization of minoxidil loaded nanostructured lipid carrier gel for effective treatment of alopecia." Saudi Pharmaceutical Journal 21.4 (2013): 379-385.
19. Pawar PM, Solanki KP, Mandali VA. Recent Advancements in Transdermal Drug Delivery System. International Journal of Pharmaceutical and Clinical Research. 2018;10(3):65-73.
20. Foldvari M, Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharmaceutical science & technology today. 2000 Dec 1;3(12):417-25.
Article Sidebar
Published
Jul 24, 2025
Article Details
How to Cite
Amol Gayke, Neha Bhoite, Vikas Shinde, Nikita Udhan, Gayatri Shinde, Poonam Chitte, Amruta Kamble, Vaishnavi Kotkar, Chandrashekar Wake, & Sushil Patil. (2025). FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL ANTIFUNGAL POLYMERIC FILM. Journal of Population Therapeutics and Clinical Pharmacology, 32(6), 1139-1153. https://doi.org/10.53555/eqsbjj76
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Author Biographies
Amol Gayke
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaNeha Bhoite
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaVikas Shinde
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaNikita Udhan
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaGayatri Shinde
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaPoonam Chitte
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaAmruta Kamble
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaVaishnavi Kotkar
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaChandrashekar Wake
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaSushil Patil
Jagdamba Education Society's, SND College of Pharmacy, Affiliated to Savitribai Phule Pune University, Pune, Babhulgaon Kh., Maharashtra 423401, IndiaHow to Cite
Amol Gayke, Neha Bhoite, Vikas Shinde, Nikita Udhan, Gayatri Shinde, Poonam Chitte, Amruta Kamble, Vaishnavi Kotkar, Chandrashekar Wake, & Sushil Patil. (2025). FORMULATION AND IN VITRO EVALUATION OF TRANSDERMAL ANTIFUNGAL POLYMERIC FILM. Journal of Population Therapeutics and Clinical Pharmacology, 32(6), 1139-1153. https://doi.org/10.53555/eqsbjj76