CALCIFYING ODONTOGENIC CYST WITH AMELOBLASTOMATOUS PROLIFERATION: A CASE REPORT AND REVIEW OF LITERATURE
Main Article Content
Keywords
.
Abstract
The calcifying odontogenic cyst (COC), also known as a Gorlin cyst, is an uncommon odontogenic lesion, accounting for only 1-2% of all jaw cysts. Initially described by Gorlin in 1962 [3], it exhibits a diverse range of clinical and histopathological characteristics. The coexistence of ameloblastomatous proliferation within a COC is exceptionally rare, with fewer than 25 reported cases globally, posing significant diagnostic and management challenges. [6,7,10] This rare finding not only highlights the uniqueness of the case but also emphasizes the critical need for meticulous histopathological examination to ensure accurate diagnosis and appropriate management, thereby improving patient outcomes.
References
2. Gade LP, Jagtap KS, Lunawat SD, Choudhary SH. Ameloblastomatous calcifying cystic odontogenic tumour involving the mandibular anterior region: An unusual case report. J Oral Maxillofac Pathol 2023; 27:216 9.
3. Gorlin, R.J., Pindborg, J.J., Clausen, F.P., & Vickers, R.A. (1962). The calcifying odontogenic cyst—a possible analogue of the cutaneous calcifying epithelioma of Malherbe. Oral Surgery, Oral Medicine, Oral Pathology, 15(6), 1235-1243.
4. Negi, M., Puri, A., Nangia, R., & Sepolia, N. (2020). Proliferating ameloblastomatous calcifying odontogenic cyst: A rare case report. Journal of Oral Research and Review, 12(2), 91-97.
5. Philipsen, H.P., Reichart, P.A., & Praetorius, F. (2000). Mixed odontogenic tumors and odontogenic carcinomas. In J. Eversole (Ed.), Contemporary Oral and Maxillofacial Pathology (pp. 295-296). St. Louis: Mosby.
6. Praetorius, F., Hjørting-Hansen, E., Gorlin, R.J., & Vickers, R.A. (1981). Calcifying odontogenic cyst. Range, variations and neoplastic potential. Acta Odontologica Scandinavica, 39(4), 227-240.
7. Regezi, J.A., Sciubba, J.J., & Jordan, R.C.K. (2002). Oral Pathology: Clinical Pathologic Correlations. 5th ed. St. Louis: Saunders.
8. Singh, H.P., & Puri, A. (2020). Ameloblastomatous Calcifying Odontogenic Cyst: Report of a Rare Case with Review of Literature. Journal of Oral and Maxillofacial Surgery, 78(3), 486-490.
9. World Health Organization (WHO). (2005). WHO Classification of Head and Neck Tumours. 4th Ed. Lyon: IARC Press.
10. Ledesma-Montes C, Gorlin R J, Shear M, Praetorius F, Mosqueda-Taylor A, Altini[3]M et al. International collaborative study on ghost cell odontogenic tumours: Calcifying cystic odontogenic tumour, dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma. J Oral Pathol Med. 2007. 37:302-08.
11. Shah U, Patel H, Pandya H, Dewan H, Bhavsar B, Steward E. Ameloblastomatous calcifying odontogenic cyst: A rare entity. Ann Maxillofac Surg 2018; 8:108‐15.
12. Hong SP, Ellis GL, Hartman KS. Calcifying odontogenic cyst. A review of ninety‐two cases with reevaluation of their nature as cysts or neoplasms, the nature of ghost cells, and sub classification. Oral Surg Oral Med Oral Pathol 1991;72:56‐64.
13. Rudraraju A, Venigalla A, Babburi S, Soujanya P, Subramanyam RV, Lakshmi KR. Calretinin expression in odontogenic cysts and odontogenic tumors and the possible role of calretinin in pathogenesis of ameloblastoma. J Oral Maxillofac Pathol 2019;23:349 55.
14. D’Silva S, Sumathi MK, Balaji N, Shetty NK, Pramod KM, Cheeramelil J, et al. Evaluation of calretinin expression in ameloblastoma and non neoplastic odontogenic cysts – An immunohistochemical study. J Int Oral Health 2013;5:42 8.
15. Diatta M, Gadji M, Dieme MJ, Abdou B A, Gassama BC, Kane M, Tamba B, Tine SD. Study of Ki67 in odontogenic benign tumors. J Oral Med, Oral Surg, Oral Pathol, Oral Radiol 2023;9(2):75-81
16. Gong, Yanling, et al. "The expression of NF-κB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC." Oral oncology 45.6 (2009): 515-520.
17. Jaafari-Ashkavandi, Zohreh, et al. "Caveolin-1 expression in odontogenic cysts and ameloblastomas." Turkish Journal of Pathology 30.2 (2014).
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Vishnu Chauhan
Government Dental College and Hospital Ahmedabad.
Dr. Sima Odedra
Government Dental College and Hospital Ahmedabad.
Dr. Karma Gohel
Government Dental College and Hospital Ahmedabad.
Dr. Ankita Makwana
Government Dental College and Hospital Ahmedabad.