A COMPARATIVE STUDY OF CLINICAL EFFICACY AND SAFETY OF GLUCOSAMINE PLUS CHONDROITIN SULPHATE VERSUS NSAIDS IN PATIENTS SUFFERING FROM OSTEOARTHRITIS
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Keywords
Osteoarthritis; Glucosamine chondroitin sulphate; WOMAC Scores
Abstract
Introduction: Osteoarthritis (OA) is a chronic degenerative joint disease in elderly with higher incidence (22-39%) in India. Despite data from previous studies the prescription of glucosamine plus chondroitin sulphate (GCS) in real-time clinical practice remains meagre. Hence, this study is conducted with the following objectives
Objectives: (1) To evaluate the efficacy of GCS and (2) To compare the efficacy and safety of GCS and NSAIDS in OA.
Materials and Methodology: This was a prospective observational study conducted among OA patients in a tertiary care teaching hospital during July 1st - October 31st 2024 after approval from Institutional Ethics Committee.
Results: Majority of the subjects were females (53.66%). By the end of the study, the mean (SD) total WOMAC score of GCS group was significantly reduced to 23.24 (14.35) with a mean difference (SE) of 13.71 (7.08) and to 18.8 (9.81) with a mean difference (SE) of 20.05 (8.52) in NSAIDs group. The mean difference (SE) of mean change (SD) WOMAC total score and sub scale score for physical function were statistically significant (p = 0.0006) between the study groups. Most common adverse effect among GCS users was abdominal bloating with flatulence while in NSAIDs users was gastro-oesophageal reflux and heart burn. CONCLUSION: This study shows the pragmatic evidence on clinical efficacy of GCS in OA of knee with maximal benefit by around 8 weeks. Though not suitable for acute OA knee but may serve as an effective alternative to NSAIDs for long-term management.
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Dr. Balla Krishna Sowmya
Assistant Professor, Department of Pharmacology, Mamata Academy of Medical Sciences, Bachupally, Telangana, India
Dheeraj Neerati
Medical Intern, Mamata Academy of Medical Sciences, Bachupally, Telangana, India
Harshitha Nookala
Medical Intern, Mamata Academy of Medical Sciences, Bachupally, Telangana, India
G V Sumakavya
Phase III MBBS student, Mamata Academy of Medical Sciences, Bachupally, Telangana, India
Dr. Sujith Kumar Vakati
Professor, Department of Orthopaedics, Mamata Academy of Medical Sciences, Bachupally, Telangana, India