MONOCYTE TO HDL RATIO AS A SHORT-TERM PROGNOSTIC MARKER IN PATIENTS WITH ACUTE CORONARY SYNDROME AND ITS CORRELATION WITH THROMBOLYSIS IN MYOCARDIAL INFARCTION (TIMI) SCORE AND ANGIOGRAPHIC PROFILE
Main Article Content
Keywords
Acute Coronary Syndrome (ACS), monocyte to HDL-c ratio (MHR), Thrombolysis in Myocardial Infarction (TIMI)
Abstract
BACKGROUND: Acute Coronary Syndrome (ACS) is a gamut of clinical conditions which occurs due to imminent, decreased blood flow to myocardial musculature. The MHR, monocyte to HDL-c ratio is a newly originated marker is based on inflammatory activity. MHR has been proposed as the latest predictor and prognostic index of acute coronary syndrome and other cardiovascular diseases.12,13 This study was conducted to assess the prognostic significance of the Monocyte to HDL ratio in ACS patients.
MATERIALS AND METHODS: A total of 41 Patients who were diagnosed with Acute Coronary syndrome without any exclusion criteria were taken in the study. Once the patients were clinically diagnosed with Acute Coronary syndrome using ECG and cardiac panel, a complete history was elicited by the doctor as the principal author as an observer. Later investigations such as CBC, Lipid Profile, echo, and angiography were carried out at the prescribed times. Risk assessment was done for every patient using the TIMI risk assessment score. Along with the data on detailed clinical history, patients’ residential address and contact numbers of the patient and emergency contact was recorded. The patients were consulted over call every month till the end of the study.
RESULTS: The age of the study samples ranged from 36 years to 67 years. The average age of the patients was 54.07土7.31 years. The average TIMI score obtained for the study population was 2.731土1.09. A TIMI score of more than one was obtained among 92.6% of the study population. Maximum patients (36.5%) obtained a TIMI score of 2. The average MHR was 19.62土6.92. MHR value is 74.6% in correlation with the TIMI score. At a cut off value of 23.75 the sensitivity and specificity of MHR for MACE were 87.5% and 88%.
CONCLUSION: MHR is a new cost-effective, logical and good predictive marker for coronary vascular diseases. Multiple studies have emphasized the utilization and findings relating to MHR. MHR can be used as a good prognostic factor for the short term, among patients with Acute Coronary syndrome.
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Dr. P. ARUN PANDIYAN
Assistant professor, Department of General Medicine, Panimalar Medical College Hospital and Research Institute, Chennai, Tamil Nadu
Dr. B. KRISHKA
Assistant professor, Department of General Medicine, Panimalar Medical College Hospital and Research Institute, Chennai, Tamil Nadu
Dr. KAMATHAM BHASKARA RAJU NAMRATHA
Assistant professor, Department of General Medicine, Madha Medical College, Chennai, Tamil Nadu