THE ROLE OF TUMOR NECROSIS FACTOR SUPERFAMILY MEMBER 14 (TNFSF14/LIGHT) IN PERIODONTAL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Abstract
Periodontitis is a multifactorial, chronic inflammatory disease initiated by dysbiotic microbial biofilms that leads to the progressive destruction of the periodontium, the specialized tissues that surround and support the teeth¹⁻³. If left untreated, this destruction can result in tooth loss, significantly impacting oral health, quality of life, and systemic health⁴. The global prevalence of severe periodontitis is estimated to be around 10-15% of the adult population, making it a major public health concern⁵.
References
1. Hajishengallis, G., & Lamont, R. J. (2021). Polymicrobial synergy and dysbiosis in inflammatory disease. Trends in immunology, 42(7), 590-603.
2. Kinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017). Periodontal diseases. Nature reviews Disease primers, 3(1), 1-14.
3. Loesche, W. J., & Grossman, N. S. (2001). Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clinical microbiology reviews, 14(4), 727-752.
4. Genco, R. J., & Borgnakke, W. S. (2020). Risk factors for periodontal disease. Periodontology 2000, 82(1), 59-94.
5. Frencken, J. E., Sharma, P., Stenhouse, L., Green, D., Laverty, D., & Dietrich, T. (2017). Global epidemiology of dental caries and severe periodontitis–a comprehensive review. Journal of clinical periodontology, 44, S94-S105.
6. Hajishengallis, G. (2015). Periodontitis: from microbial immune subversion to systemic inflammation. Nature reviews immunology, 15(1), 30-44.
7. Graves, D. T. (2008). The potential role of chemokines and inflammatory cytokines in periodontal wound healing. Periodontology 2000, 48(1), 8-19.
8. Silva, N., Dutzan, N., Hernandez, M., Dezerega, A., & Gamonal, J. (2008). Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells. Journal of clinical periodontology, 35(3), 206-214.
9. Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nature reviews immunology, 3(9), 745-756.
10. Croft, M., Benedict, C. A., & Ware, C. F. (2013). Clinical targeting of the TNF and TNFR superfamilies. Nature reviews Drug discovery, 12(2), 147-168.
11. Kirkwood, K. L., Cirelli, J. A., Rogers, J. E., & Giannobile, W. V. (2007). Novel host response therapeutic approaches to treat periodontal diseases. Periodontology 2000, 43(1), 294-315.
12. Mauri, D. N., Ebner, R., Montgomery, R. I., et al. (1998). LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity, 8(1), 21-30.
13. Steinberg, M. W., Cheung, T. C., & Ware, C. F. (2008). The signaling of transmembrane lymphotoxin-α and LIGHT. Frontiers in bioscience: a journal and virtual library, 13, 4841-4857.
14. Granger, S. W., & Rickert, S. (2003). LIGHT-ing the way to new therapies. Current opinion in pharmacology, 3(5), 533-539.
15. Scheu, S., Alferink, J., Pötzel, T., et al. (2002). Targeted disruption of LIGHT causes defects in T cell activation and reveals a specialized role for LIGHT in initiating T helper cell responses. The Journal of experimental medicine, 195(12), 1613-1624.
16. Fava, R. A., Notidis, E., Hunt, J., et al. (2003). A role for LIGHT in the pathogenesis of joint inflammation and destruction. The Journal of Immunology, 171(1), 115-126.
17. Cohavy, O., Targan, S. R., & Mizoguchi, E. (2005). Spontaneous colitis in developing T cell receptor α-chain and T cell receptor β-chain double-knockout mice indicates a role for the T cell receptor-independent pathway in immunologically mediated bowel disease. Clinical and experimental immunology, 139(2), 246-254.
18. Schreyer, S. A., Vick, C. M., & LeBoeuf, R. C. (2002). Loss of lymphotoxin-α, but not tumor necrosis factor, protects against diet-induced atherosclerosis in mice. The Journal of clinical investigation, 110(1), 89-96.
19. Vernal, R., Dutzan, N., Chaparro, A., et al. (2008). Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. Journal of clinical periodontology, 35(11), 923-929.
20. Bostanci, N., & Belibasakis, G. N. (2012). Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS microbiology letters, 333(1), 1-9.
21. Ottonello, L., Frumento, G., Arduino, N., et al. (2004). The T-cell-derived cytokine LIGHT enhances the matrix-degrading activity of fibroblasts. The Journal of Immunology, 173(4), 2733-2741.
22. Özçaka Ö, Nalbantsoy A, Buduneli N, Lappin DF. Salivary and gingival crevicular fluid levels of LIGHT in patients with chronic periodontitis. Journal of Clinical Periodontology. 2011;38(11):989-995.
23. Lappin DF, Apatzidou DA, Millhouse E, Riggio MP, Kinane DF. The RANKL/OPG/LIGHT/DcR3 axis in periodontal disease. Journal of Clinical Periodontology. 2013;40(3):218-226.
24. Bozkurt FY, Yetkin Ay Z, Sütçü R, Delibaş N, Demirel R. Salivary and serum concentrations of LIGHT in patients with chronic and aggressive periodontitis. Journal of Periodontology. 2014;85(11):1556-1562.
25. Araujo VM, Melo IM, Lima V. Gingival crevicular fluid levels of LIGHT in periodontal disease. Journal of Periodontal Research. 2015;50(4):548-554.
26. Severino F, de Lima CL, Ribeiro IWJ, et al. Salivary levels of LIGHT and DcR3 in chronic periodontitis. Archives of Oral Biology. 2019;107:104505.
27. Gürkan A, Eren G, Trak M, Akbaş F. Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum LIGHT and decorin levels in patients with stage III grade C periodontitis. Journal of Periodontal Research. 2020;55(5):673-682.
28. Lamster, I. B., & Ahlo, J. K. (2007). Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases. Annals of the New York Academy of Sciences, 1098(1), 216-229.
29. D’Aiuto, F., Gkranias, N., & Bhowruth, D. (2018). Systemic effects of periodontitis–a dental clinical perspective. Chinese Journal of Dental Research, 21(2), 97.
30. Shaikh, R. B., & Santis, A. G. (2002). LIGHT: a new beacon in the T-cell-mediated inflammatory response. Immunology today, 23(2), 66-69.
31. Cochran, D. L. (2008). Inflammation and bone loss in periodontal disease. Journal of periodontology, 79, 1569-1576.
32. Rooney, I. A., Butrovich, K. D., & Ware, C. F. (2000). The lymphotoxin-β receptor. Journal of leukocyte biology, 68(3), 305-312.
33. Gommerman, J. L., & Browning, J. L. (2003). Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nature Reviews Immunology, 3(8), 642-655.
2. Kinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017). Periodontal diseases. Nature reviews Disease primers, 3(1), 1-14.
3. Loesche, W. J., & Grossman, N. S. (2001). Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clinical microbiology reviews, 14(4), 727-752.
4. Genco, R. J., & Borgnakke, W. S. (2020). Risk factors for periodontal disease. Periodontology 2000, 82(1), 59-94.
5. Frencken, J. E., Sharma, P., Stenhouse, L., Green, D., Laverty, D., & Dietrich, T. (2017). Global epidemiology of dental caries and severe periodontitis–a comprehensive review. Journal of clinical periodontology, 44, S94-S105.
6. Hajishengallis, G. (2015). Periodontitis: from microbial immune subversion to systemic inflammation. Nature reviews immunology, 15(1), 30-44.
7. Graves, D. T. (2008). The potential role of chemokines and inflammatory cytokines in periodontal wound healing. Periodontology 2000, 48(1), 8-19.
8. Silva, N., Dutzan, N., Hernandez, M., Dezerega, A., & Gamonal, J. (2008). Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells. Journal of clinical periodontology, 35(3), 206-214.
9. Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nature reviews immunology, 3(9), 745-756.
10. Croft, M., Benedict, C. A., & Ware, C. F. (2013). Clinical targeting of the TNF and TNFR superfamilies. Nature reviews Drug discovery, 12(2), 147-168.
11. Kirkwood, K. L., Cirelli, J. A., Rogers, J. E., & Giannobile, W. V. (2007). Novel host response therapeutic approaches to treat periodontal diseases. Periodontology 2000, 43(1), 294-315.
12. Mauri, D. N., Ebner, R., Montgomery, R. I., et al. (1998). LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity, 8(1), 21-30.
13. Steinberg, M. W., Cheung, T. C., & Ware, C. F. (2008). The signaling of transmembrane lymphotoxin-α and LIGHT. Frontiers in bioscience: a journal and virtual library, 13, 4841-4857.
14. Granger, S. W., & Rickert, S. (2003). LIGHT-ing the way to new therapies. Current opinion in pharmacology, 3(5), 533-539.
15. Scheu, S., Alferink, J., Pötzel, T., et al. (2002). Targeted disruption of LIGHT causes defects in T cell activation and reveals a specialized role for LIGHT in initiating T helper cell responses. The Journal of experimental medicine, 195(12), 1613-1624.
16. Fava, R. A., Notidis, E., Hunt, J., et al. (2003). A role for LIGHT in the pathogenesis of joint inflammation and destruction. The Journal of Immunology, 171(1), 115-126.
17. Cohavy, O., Targan, S. R., & Mizoguchi, E. (2005). Spontaneous colitis in developing T cell receptor α-chain and T cell receptor β-chain double-knockout mice indicates a role for the T cell receptor-independent pathway in immunologically mediated bowel disease. Clinical and experimental immunology, 139(2), 246-254.
18. Schreyer, S. A., Vick, C. M., & LeBoeuf, R. C. (2002). Loss of lymphotoxin-α, but not tumor necrosis factor, protects against diet-induced atherosclerosis in mice. The Journal of clinical investigation, 110(1), 89-96.
19. Vernal, R., Dutzan, N., Chaparro, A., et al. (2008). Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. Journal of clinical periodontology, 35(11), 923-929.
20. Bostanci, N., & Belibasakis, G. N. (2012). Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS microbiology letters, 333(1), 1-9.
21. Ottonello, L., Frumento, G., Arduino, N., et al. (2004). The T-cell-derived cytokine LIGHT enhances the matrix-degrading activity of fibroblasts. The Journal of Immunology, 173(4), 2733-2741.
22. Özçaka Ö, Nalbantsoy A, Buduneli N, Lappin DF. Salivary and gingival crevicular fluid levels of LIGHT in patients with chronic periodontitis. Journal of Clinical Periodontology. 2011;38(11):989-995.
23. Lappin DF, Apatzidou DA, Millhouse E, Riggio MP, Kinane DF. The RANKL/OPG/LIGHT/DcR3 axis in periodontal disease. Journal of Clinical Periodontology. 2013;40(3):218-226.
24. Bozkurt FY, Yetkin Ay Z, Sütçü R, Delibaş N, Demirel R. Salivary and serum concentrations of LIGHT in patients with chronic and aggressive periodontitis. Journal of Periodontology. 2014;85(11):1556-1562.
25. Araujo VM, Melo IM, Lima V. Gingival crevicular fluid levels of LIGHT in periodontal disease. Journal of Periodontal Research. 2015;50(4):548-554.
26. Severino F, de Lima CL, Ribeiro IWJ, et al. Salivary levels of LIGHT and DcR3 in chronic periodontitis. Archives of Oral Biology. 2019;107:104505.
27. Gürkan A, Eren G, Trak M, Akbaş F. Effect of non-surgical periodontal treatment on gingival crevicular fluid and serum LIGHT and decorin levels in patients with stage III grade C periodontitis. Journal of Periodontal Research. 2020;55(5):673-682.
28. Lamster, I. B., & Ahlo, J. K. (2007). Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases. Annals of the New York Academy of Sciences, 1098(1), 216-229.
29. D’Aiuto, F., Gkranias, N., & Bhowruth, D. (2018). Systemic effects of periodontitis–a dental clinical perspective. Chinese Journal of Dental Research, 21(2), 97.
30. Shaikh, R. B., & Santis, A. G. (2002). LIGHT: a new beacon in the T-cell-mediated inflammatory response. Immunology today, 23(2), 66-69.
31. Cochran, D. L. (2008). Inflammation and bone loss in periodontal disease. Journal of periodontology, 79, 1569-1576.
32. Rooney, I. A., Butrovich, K. D., & Ware, C. F. (2000). The lymphotoxin-β receptor. Journal of leukocyte biology, 68(3), 305-312.
33. Gommerman, J. L., & Browning, J. L. (2003). Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nature Reviews Immunology, 3(8), 642-655.
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Jan 20, 2023
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Dr. Tejinder Pal Singh, Dr. Taruna Mahant, & Dr. Rajat Kumar. (2023). THE ROLE OF TUMOR NECROSIS FACTOR SUPERFAMILY MEMBER 14 (TNFSF14/LIGHT) IN PERIODONTAL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal of Population Therapeutics and Clinical Pharmacology, 30(1), 8066-8071. https://doi.org/10.53555/s2v17w73
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Author Biographies
Dr. Tejinder Pal Singh
Associate Professor, Dept of Periodontology & Oral Implantology Gian Sagar Dental College & Hospital, Ramnagar, Rajpura
Dr. Taruna Mahant
Assistant Professor, Dept of Oral Medicine & Radiology, Gian Sagar Dental College & Hospital, Ramnagar, Rajpura
Dr. Rajat Kumar
Dental Surgeon, Dental Aesthetics, Kamal Colony Sirhind Road, Patiala
How to Cite
Dr. Tejinder Pal Singh, Dr. Taruna Mahant, & Dr. Rajat Kumar. (2023). THE ROLE OF TUMOR NECROSIS FACTOR SUPERFAMILY MEMBER 14 (TNFSF14/LIGHT) IN PERIODONTAL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Journal of Population Therapeutics and Clinical Pharmacology, 30(1), 8066-8071. https://doi.org/10.53555/s2v17w73