TO DETERMINE THE PATHOGENIC PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN IN BRONCHIECTASIS PATIENTS IN SOUTHERN KPK

Main Article Content

Qaisar Iqbal
Tahir Ullah Khan
Nafid Ullah Khan
Mohib Ullah Khan
Wajid Khan
Kamran Khan

Keywords

Bronchiectasis, respiratory pathogens

Abstract

Objective: To determine the pathogenic profile and antimicrobial susceptibility pattern in bronchiectasis in southern KPK.


Materials and Methods: This Cross-sectional, descriptive study was conducted in department of Medicine, MTI - DHQ Hospital, Bannu from 1st December, 2024 to 31st May, 2025. Patients included in this study were known to have bronchiectasis on the basis of radiological findings and presenting to pulmonology OPD with fever and copious amount of sputum for more than two weeks. Sputum cultures were collected according to standard laboratory protocol and analyzed as per established guidelines. Data was analyzed through latest SPSS Version.


Results: In this study, a total of 76 patients with bronchiectasis were assessed with sputum culture and antibiotic susceptibility pattern of the common respiratory pathogens were measured. Every respiratory pathogen was assessed for 5 common antibiotics and antibiotic susceptibility pattern was established.


Conclusion: Knowledge of the pathogenic profile and antibiotic susceptibility pattern of common respiratory pathogens in bronchiectasis is important in terms of developing effective treatment strategies. Further research to effectively address the issue of antibiotic resistance and develop novel antibiotics id is needed.

Abstract 75 | Pdf Downloads 25

References

1. Shahid S, bin Abdul Jabbar A, Wagley A, Musharraf MD, Zahid H, Zubair SM, Irfan M. Non-cystic fibrosis bronchiectasis: a retrospective review of clinical, radiological, microbiological and lung function profile at a tertiary care center of a low-middle-income country. Monaldi Archives for Chest Disease. 2024;94(3).
2. Hoole AS, Ilyas A, Munawar S, Cant M, Hameed R, Gill S, Riaz J, Siddiq I. Post Tuberculosis (TB) Bronchiectasis versus Non-TB Bronchiectasis in Northern Pakistan: A single centre retrospective cohort study on frequency, demographics, microbiology, and complications. medRxiv. 2024 Feb 20:2024-02.
3. Shahid S, Jabeen K, Iqbal N, Farooqi J, Irfan M. Respiratory pathogens in patients with acute exacerbation of non-cystic fibrosis bronchiectasis from a developing country. Monaldi Archives for Chest Disease. 2021.
4. Ahmed I, Tiberi S, Farooqi J, Jabeen K, Yeboah-Manu D, Migliori GB, Hasan R. Non-tuberculous mycobacterial infections—A neglected and emerging problem. International Journal of Infectious Diseases. 2020 Mar 1;92:S46-50.
5. Shahid S, bin Abdul Jabbar A, Wagley A, Musharraf MD, Zahid H, Zubair SM, Irfan M. Non-cystic fibrosis bronchiectasis: a retrospective review of clinical, radiological, microbiological and lung function profile at a tertiary care center of a low-middle-income country. Monaldi Archives for Chest Disease. 2024;94(3).
6. Brohi NA, Saifullah N, Jamali SA, Chachar H, Qazi MA, Jamali AA. ASSESSMENT OF PATIENTS HAVING ACUTE EXACERBATION OF BRONCHIECTASIS AND FACTORS LEADING TO MORTALITY IN THE HOSPITALIZED PATIENTS AT PULMONOLOGY DEPARTMENT JINNAH POSTGRADUATE MEDICAL CENTRE KARACHI. Journal of Peoples University of Medical & Health Sciences Nawabshah.(JPUMHS). 2022 Mar 31;12(1):23-30.
7. Gao YH, Guan WJ, Zhu YN, Chen RC, Zhang GJ. Antibiotic-resistant Pseudomonas aeruginosa infection in patients with bronchiectasis: prevalence, risk factors and prognostic implications. International journal of chronic obstructive pulmonary disease. 2018 Jan 9:237-46.
8. Inchingolo R, Pierandrei C, Montemurro G, Smargiassi A, Lohmeyer FM, Rizzi A. Antimicrobial resistance in common respiratory pathogens of chronic bronchiectasis patients: a literature review. Antibiotics. 2021 Mar 20;10(3):326.
9. 9. King PT. The pathophysiology of bronchiectasis. International journal of chronic obstructive pulmonary disease. 2009 Nov 29:411-9.
10. Keir HR, Chalmers JD. Pathophysiology of bronchiectasis. InSeminars in respiratory and critical care medicine 2021 Aug (Vol. 42, No. 04, pp. 499-512). Thieme Medical Publishers, Inc..
11. Smith MP. Diagnosis and management of bronchiectasis. Cmaj. 2017 Jun 19;189(24):E828-35.
12. Cabrera R, Fernández-Barat L, Vázquez N, Alcaraz-Serrano V, Bueno-Freire L, Amaro R, López-Aladid R, Oscanoa P, Muñoz L, Vila J, Torres A. Resistance mechanisms and molecular epidemiology of Pseudomonas aeruginosa strains from patients with bronchiectasis. Journal of Antimicrobial Chemotherapy. 2022 Jun 1;77(6):1600-10.
13. Smith AL, Fiel SB, Mayer-Hamblett N, Ramsey B, Burns JL. Susceptibility testing of Pseudomonas aeruginosa isolates and clinical response to parenteral antibiotic administration: lack of association in cystic fibrosis. Chest. 2003 May 1;123(5):1495-502.
14. Hill D, Rose B, Pajkos A, Robinson M, Bye P, Bell S, Elkins M, Thompson B, MacLeod C, Aaron SD, Harbour C. Antibiotic susceptibilities of Pseudomonas aeruginosa isolates derived from patients with cystic fibrosis under aerobic, anaerobic, and biofilm conditions. Journal of clinical microbiology. 2005 Oct;43(10):5085-90.

15. Watts SC, Judd LM, Carzino R, Ranganathan S, Holt KE. Genomic diversity and antimicrobial resistance of Haemophilus colonizing the airways of young children with cystic fibrosis. Msystems. 2021 Aug 31;6(4):10-128.

16. Simon HB, Southwick FS, Moellering RC, Sherman E. Hemophilus influenzae in hospitalized adults: current perspectives. The American Journal of Medicine. 1980 Aug 1;69(2):219-26.

17. Mossman AK, Svishchuk J, Waddell BJ, Izydorczyk CS, Buckley PT, Hilliard JJ, Al-Ghalith G, Zheng L, Lynch AS, Mody CH, Lisboa LF. Staphylococcus aureus in Non–Cystic Fibrosis Bronchiectasis: Prevalence and Genomic Basis of High Inoculum β-Lactam Resistance. Annals of the American Thoracic Society. 2022 Aug;19(8):1285-93.