PROSPECTIVE EVALUATION OF SERUM VITAMIN D LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS AND CORRELATION WITH GLYCEMIC CONTROL
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Keywords
Type 2 Diabetes Mellitus, Vitamin D, HbA1c, Glycemic Control, Biochemistry
Abstract
Background: Type 2 Diabetes Mellitus (T2DM) is a growing global health concern. Recent evidence suggests a potential link between Vitamin D deficiency and poor glycemic control. This study aimed to evaluate serum Vitamin D levels in T2DM patients and analyze their correlation with glycemic parameters.
Methods: This prospective observational study was conducted in the Department of Biochemistry, FH Medical College, Agra over 12 months. A total of 150 diagnosed T2DM patients were included. Serum 25(OH) Vitamin D and glycemic parameters (HbA1c, Fasting Blood Glucose [FBG], Postprandial Blood Glucose [PPBG]) were measured and analyzed.
Results: Vitamin D deficiency (<20 ng/mL) was observed in 68% of patients. A statistically significant inverse correlation was found between serum Vitamin D levels and HbA1c (r = –0.42, p < 0.01). Similar trends were seen with FBG and PPBG.
Conclusion: Vitamin D deficiency is highly prevalent in T2DM patients and is significantly associated with poor glycemic control. Screening and supplementation of Vitamin D may serve as an adjunct in the management of T2DM.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Ashish Jain
Associate Professor, Department of Biochemistry, FH Medical College, Agra, India
Mani Kant Choudhary
Assistant Professor, Department of Biochemistry, FH Medical College, Agra, India
Arvind Bharti
Assistant Professor, Department of Biochemistry, FH Medical College, Agra, India
Bhumija Sharma
Lecturer – Human Molecular & Genetics, School of Dentistry and Health Sciences,
Charles Sturt University, Wagga Wagga, Australia