FREQUENCY OF HYPERHOMOCYSTEINEMIA IN YOUNG PATIENTS WITH ACUTE ISCHEMIC STROKE
Main Article Content
Keywords
Hyperhomocysteinemia, ischemic stroke, young adults, risk factors, homocysteine.
Abstract
Introduction: Hyperhomocysteinemia, characterized by elevated homocysteine levels, is an emerging risk factor for acute ischemic stroke in young adults (≤45 years). Its role in stroke pathogenesis, particularly in South Asia, remains understudied despite its potential for early intervention.
Objective: To determine the frequency of hyperhomocysteinemia in young patients with acute ischemic stroke and evaluate its role as a risk factor.
Materials and Method: This cross-sectional study, conducted at Hayatabad Medical Complex Peshawar, Pakistan, from January 2024 to June 2024, enrolled 150 patients aged 18–45 years with confirmed ischemic stroke. Serum homocysteine levels were measured, with >15 µmol/L defined as hyperhomocysteinemia. Data were analyzed using SPSS version 25.
Results: Hyperhomocysteinemia was observed in 44.7% (n=67) of patients, predominantly males (71.6%). It was significantly associated with moderate-to-severe stroke (p<0.05), with smoking (46.3%) and hypertension (35.8%) as common coexisting risk factors.
Conclusion: Hyperhomocysteinemia is prevalent in young stroke patients in Pakistan and is linked to increased stroke severity. Routine screening and targeted interventions, such as vitamin supplementation, could reduce stroke burden.
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Dr Muhammad Owais Khan
Consultant Neurologist, Specialist Registrar Neurology Unit, Hayatabad Medical Complex Peshawar, Pakistan
Dr Harwindar Kumar
FCPS Neurology, MRCP UK, FEBN, Consultant Neurologist Buner Medical Center Buner KPK, Pakistan
Dr Ushna Ahmed Qureshi
Consultant Neurologist, DHQ Teaching Hospital Kohat, Pakistan
Dr Fawad Ali
Senior Registrar Neurology, Medicine Department, Saidu Medical College and Saidu Group of Teaching Hospital Swat SGTH, Pakistan
Dr Rimsha Shais
Final Year (FCPS Resident), Paediatric Unit, Rehman Medical Institute Peshawar, Pakistan
Dr Husnain Hashim
Consultant Neurologist and Stroke Specialist, Assistant Professor, Fauji Foundation Hospital Rawalpindi, Pakistan