PATTERN OF ADVERSE DRUG REACTION ASSOCIATED TO ANTIPSYCHOTIC DRUGS WITH SPECIAL REFERENCE TO HYPONATRAEMIA IN MEDICAL COLLEGE, KOLKATA: AN OBSERVATIONAL, CROSS-SECTIONAL STUDY
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Keywords
Hyponatremia, Antipsychotics, Risperidone, Olanzapine, Aripiprazole, SIADH, Electrolyte Disturbance, Pharmacovigilance, Geriatric Psychiatry, Serum Sodium, Adverse Drug Reaction.
Abstract
The therapeutic armamentarium for psychotic spectrum disorders has undergone a profound metamorphosis with the advent of antipsychotic pharmacotherapeutics. The evolution from classical first-generation dopamine D2 antagonists, such as haloperidol and chlorpromazine, to more receptor-diverse second-generation antipsychotics (SGAs) including risperidone, olanzapine, and aripiprazole, has redefined the neuropsychopharmacology paradigm²˒³˒²². However, this progress has not been without the collateral burden of a diverse array of adverse drug reactions (ADRs), which complicate long-term clinical management, impede compliance, and potentiate iatrogenic morbidity
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Dr. Suhena Sarkar
MBBS(Hons), MD, Associate Professor, Department of Pharmacology, Medical College, Kolkata, India, {ORCID number 0000-0002-7430-4643}
Dr.Roshni Banerjee
MBBS, Post Graduate Trainee (MD), Department of Pharmacology, Medical College, Kolkata, India
Dr.Papia Sen
Demonstrator, Department of Pharmacology, Medical College, Kolkata, India
Dr.Arpita Bain
MBBS, Post Graduate Trainee (MD), Department of Pharmacology, Medical College, Kolkata, India,{ORCID number 0009-0005-2046-486X}
Dr Birupaksha Biswas
MBBS, MD, Senior Resident, Department of Pathology, Burdwan Medical College & Hospital, Burdwan, India, {ORCID number 0009-0007-5701-9131}