RELATIONSHIP OF ADIPONECTIN WITH INSULIN RESISTANCE, LIPID PROFILE AND BODY MASS INDEX
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Abstract
Adiponectin is a fat derived protein. It is linked to obesity and its co-morbidities especially insulin resistance, type 2 diabetes, and certain components of metabolic syndrome.
Objective: The objective of this study was to correlate serum adiponectin levels with Insulin sensitivity, Lipid Profile and with BMI in self-reported healthy individuals. and to evaluate the relationship between serum adiponectin levels and key metabolic parameters including insulin resistance (HOMA-IR), lipid profile, and body mass index (BMI) in self-reported healthy individuals from the Pakistani population.
Methods: We designed a cross-sectional analytical study and recruited a cohort of eighty (80) self-reported healthy individuals in the study by non-probability convenient sampling. The whole experimental work was conducted at the Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore from September 2021 to June 2022. The adiponectin levels in patients’ serum were assessed by ELISA kit. Lipid profile was assessed by commercial Human Diagnostics® kits.
Results: Our results showed that mean value of serum adiponectin levels in subjects was 5.55±1.93 (Mean±SD) with no significant difference between male (5.43± 1.35) and female subjects (5.75 ± 2.59) at p>0.50. There was no significant correlation between adiponectin and any of the anthropometric or metabolic parameters including waist circumference, BMI, blood sugar fasting, serum insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and lipid profile at p>0.50 when checked by Spearman correlation testing. However, when multiple linear regression was used to check the association of adiponectin levels with waist circumference while controlling age and serum lipids, a statistically significant link was revealed (beta=0.34, p=0.03).
Conclusions: Our study adds to the developing pool of knowledge about the physiological role of adiponectin. There is no simple correlation of this adipokine with anthropometric and metabolic parameters. A positive association with waist circumference may be linked to the visceral intraabdominal fat which is a source of this adipokine. More studies are required to find out physiological role of adipokines on genetic and molecular grounds.
References
2. Zaidi H. Abdominal adipose tissue associates with adiponectin and TNF in middle-aged healthy men. Atherosclerosis. 2022 Aug 1;355:134. oi: 10.3389/fendo.2022.874977. eCollection 2022.
3. Swarup S, Goyal A, Grigorova Y, Zeltser R. Metabolic Syndrome [Updated 2022 Oct 24]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023.
4. Bungau AF, Tit DM, Stoicescu M, Moleriu LC, Muresan M, Radu A, Brisc MC, Ghitea TC. Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase. Medicina. 2024 Mar 21;60(3):513. doi: 10.3390/medicina60030513.
5. Balsan GA, Vieira JL, Oliveira AM, Portal VL. Relationship between adiponectin, obesity and insulin resistance. Revista da Associação Médica Brasileira. 2015 Jan;61:72-80. doi: 10.1590/1806-9282.61.01.072. Epub 2015 Jan 1.
6. De Bernardi Rodrigues AM, da Silva Cde C, Vasques AC, Camilo DF, Barreiro F, Cassani RS, Zambon MP, Antonio MA, Geloneze B. Brazilian Metabolic Syndrome Study (BRAMS) Investigators. Association of sleep deprivation with reduction in insulin sensitivity as assessed by the hyperglycemic clamp technique in adolescents. JAMA Pediatr. 2016;170(5):487-94. doi: 10.1371/journal.pone.0214081. eCollection 2019.
7. Wang G, Wang Y, Luo Z. Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta‐Analysis. Cardiovascular Therapeutics. 2022;2022(1):4395266. doi: 10.1155/2022/4395266. eCollection 2022.
8. Gunturiz Albarracín, M. L., & Forero Torres, A. Y. (2020). Adiponectin and leptin adipocytokines in metabolic syndrome: what is its importance?. Dubai Diabetes and Endocrinology Journal, 26(3), 93-102.
9. Khalafi, M., Sakhaei, M. H., Kheradmand, S., Symonds, M. E., & Rosenkranz, S. K. (2023). The impact of exercise and dietary interventions on circulating leptin and adiponectin in individuals who are overweight and those with obesity: A systematic review and meta-analysis. Advances in Nutrition, 14(1), 128-146. doi: 10.1016/j.advnut.2022.10.001. Epub 2022 Dec 15.
10. Luo, L., & Liu, M. (2022). Adiponectin: Friend or foe in obesity and inflammation. Medical Review, 2(4), 349-362. Luo, L., & Liu, M. (2022). Adiponectin: Friend or foe in obesity and inflammation. Medical Review, 2(4), 349-362.
11. Nawai F, Syauqy A, Pramono A. Correlation of lipid profile, glucose, and body composition on insulin resistance in overweight and obese subjects. AcTion: Aceh Nutrition Journal. 2024 Mar 15;9(1):141-9.
12. Shabu SA, Saka MH, Boya MN, Ahmed HM, Zaki SM, Hettinga F, Shabila NP. Association between body weight perception and actual body mass index among adult women in Erbil city, Iraq. Journal of Health, Population and Nutrition. 2024 Jan 29;43(1):15. doi: 10.1186/s41043-024-00512-8.
13. Ali MH, Alshawi A. High-Molecular weight Adiponectin, and TyG-BMI, are better predictive markers than TyG index and HbA1c to predict pre-diabetes in overweight adults. Ain Shams Medical Journal. 2024 Mar 1;75(1):37-46.
14. Khabour OF, Alomari MA, Abu Obaid AA. The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women. Dermatoendocrinol. 2018 Jun 18;10(1). doi: 10.1080/19381980.2018.1477902. eCollection 2018.
15. Tamang HK, Timilsina U, Singh KP, Shrestha S, Pandey B, Basnet S, Waiba B, Shrestha U. Assessment of adiponectin level in obese and lean Nepalese population and its possible correlation with lipid profile: A cross-sectional study. Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S349-54. doi: 10.4103/2230-8210.119618
16. Nigro E, Scudiero O, Ludovica Monaco M, Polito R, Schettino P, Grandone A, Perrone L, Miraglia Del Giudice E, Daniele A. Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance. Cytokine. 2017 Jun;94:8-13. doi: 10.1016/j.cyto.2016.12.018. Epub 2017 Apr 3.
17. Bhosle, D., Sayyed, A., Bhagat, A., Sheikh, H., & Londhe, V. (2016). Homeostasis model assessment of insulin resistance (HOMA-IR) in the diagnosis of insulin resistance and prediabetes. J Med Sci Clin Res, 4(9), 12705-12710.
18. Aisike G, Kuerbanjiang M, Muheyati D, Zaibibuli K, Lv MX, Han J. Correlation analysis of obesity phenotypes with leptin and adiponectin. Sci Rep. 2023 Oct 18;13(1):17718. doi: 10.1038/s41598-023-43550-8.
19. Park S, Shimokawa I. Influence of Adipokines on Metabolic Dysfunction and Aging. Biomedicines. 2024 Apr 15;12(4):873.
20. Becerril S, Rodríguez A, Catalán V, Ramírez B, Mentxaka A, Neira G, Gómez-Ambrosi J, Frühbeck G. Sex- and Age-Dependent Changes in the Adiponectin/Leptin Ratio in Experimental Diet-Induced Obesity in Mice. Nutrients. 2022 Dec 23;15(1):73. doi: 10.3390/biomedicines12040873.
21. Hong X, Zhang X, You L, Li F, Lian H, Wang J, Mao N, Ren M, Li Y, Wang C, Sun K. Association between adiponectin and newly diagnosed type 2 diabetes in population with the clustering of obesity, dyslipidaemia and hypertension: a cross-sectional study. BMJ Open. 2023 Feb 24;13(2) Hong X, Zhang X, You L, Li F, Lian H, Wang J, Mao N, Ren M, Li Y, Wang C, Sun K. Association between adiponectin and newly diagnosed type 2 diabetes in population with the clustering of obesity, dyslipidaemia and hypertension: a cross-sectional study. BMJ Open. 2023 Feb 24;13(2)
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Foquia Tasser Hunan
Postgraduate Resident in the Department of Dermatology, Rashid Latif Medical College, Lahore.
Nooria Naeem
Assistant Professor Physiology, University College of Medicine & Dentistry, The University of Lahore.
Zobiah Hafeez
Assistant Professor Physiology, University College of Medicine & Dentistry, The University of Lahore.
Chaman Nasrullah
Assistant Professor Physiology, University College of Medicine & Dentistry, The University of Lahore.
Sara Mukhtar
Professor of Physiology, University College of Medicine & Dentistry, The University of Lahore.
Maimoona Nasreen
Professor of Physiology, University College of Medicine & Dentistry, The University of Lahore.