ASSOCIATION OF CORRECTED QT INTERVAL WITH MICROVASCULAR COMPLICATIONS OF TYPE 2 DIABETES MELLITUS
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Keywords
Type 2 diabetes mellitus, microvascular complications, QTc interval
Abstract
Background and Objectives: There is a rising incidence of type 2 diabetes mellitus, and hyperglycaemia is known to cause microvascular complications and macrovascular complications like ischemic heart disease and sudden cardiac death. Each microvascular complication is an independent risk factor for sudden cardiac death. QT interval, corrected for heart rate, is a simple electrocardiogram (ECG)-based method indicating cardiac repolarization abnormality. Prolonged QTc lowers the threshold for life-threatening cardiac arrhythmias. The present study examines the association of QTc interval with microvascular complications in diabetes mellitus.
Methods: A cross-sectional study was conducted from January 2020 to June 2021. A total of 117 patients with type 2 diabetes mellitus were enrolled after obtaining informed consent. All participants underwent clinical examination and laboratory investigations. Statistical analysis was performed to correlate the QTc interval with microvascular complications using SPSS software. Unpaired t-test and chi-square test were applied.
Results: Out of 117 patients, 45 were female and 72 were male. Prolonged QT interval was found in 12% of participants (p < 0.001). There was no significant difference in age, duration of diabetes, or glycemic control between those with and without prolonged QT. QT prolongation was significantly associated with diabetic retinopathy (20.3%), nephropathy (22.9%), and neuropathy (29.0%).
Conclusion: There is a significant association between QT interval prolongation and the severity and multiplicity of diabetic microvascular complications. QTc interval serves as a simple and cost-effective method for early detection of cardiovascular risk in patients with type 2 diabetes mellitus.
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Dr. Tejashree Pasumarthy
Post graduate, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore- 560066
Dr. Fareeha Afreen
Post graduate, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore- 560066
Dr. Pooja Rajesh Naik
Assistant professor, department of general medicine, KLE JGMMMC,Hubli, Kle academy of Higher education and Research"
Dr. Seetha VSR Prashanthi
Post graduate, Department of General Medicine, Vydehi Institute of Medical Sciences and Research Centre,Bangalore- 560066
Dr. Javeria Afshan
Senior Resident, Department of General Medicine Bangalore Medical College and Research Institute