FORMULATION AND ASSESSMENT OF LIPOSOMAL DELIVERY SYSTEMS FOR TARGETED HEPATOPROTECTIVE DRUG DELIVERY TO THE LIVER
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Keywords
Lipid Microspheres, Silymarin, Soya Lecithin
Abstract
This study investigates the development of silymarin-loaded lipid microspheres aimed at enhancing the hepatic delivery and bioavailability of silymarin, a known hepatoprotective agent. Liposomes, niosomes, and lipid emulsions were considered as potential carriers, with lipid emulsions selected due to their favorable properties. Soybean lecithin and Tween 80 were used as surfactants, with soybean oil as the lipid phase. The formulations were characterized in terms of drug release, size distribution, stability, and drug-holding capacity. The silymarin lipid emulsion (Formulation A) exhibited significantly higher drug release compared to a silymarin solution (Formulation B), demonstrating superior stability and drug retention. Transmission electron microscopy (TEM) confirmed the near-spherical shape of the microspheres, with a size range of 0.31–1.24 µm. The drug release from Formulation A was enhanced, indicating its potential for targeted liver delivery with minimized drug loss during transit.
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Dr. Shraddha Sanghani
Assistant Professor, Department of General Medicine, Aarupadai Veedu Medical College and Hospital, Kirumampakkam, Bahour Commune Panchayat, Puducherry – 607402