EXTRACTION AND EVALUATION OF NIGELLA SATIVA AND SYZYGIUM AROMATICUM OILS AND THEIR PHARMACOLOGICAL STANDARDIZATION
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Keywords
Nigella sativa, Syzygium aromaticum, Anti-microbial, Antioxidant and Anti-inflammatory agent.
Abstract
Nigella sativa (black seed) and Syzygium aromaticum (clove) have been widely recognized for their medicinal and pharmacological significance, primarily due to their bioactive compounds—thymoquinone and eugenol, respectively. This study focused on the extraction of essential oils by using the cold compression method and to evaluates their antioxidant, anti-inflammatory, and antimicrobial activities. The antimicrobial efficacy of the both extracted oils were assessed against common pathogenic microorganisms including both Gram-positive and Gram-negative bacterial strains against standardized antimicrobial testing methods. The results indicated that both the study samples (oils) exhibited notable antimicrobial properties along with promising antioxidant and anti-inflammatory activities. In addition, both reinforcing the antimicrobial potential as natural therapeutic agents. Standardization processes were conducted to ensure consistency, potency, and safety, to establish their viability for pharmaceutical applications. This research underscores the potential of Nigella sativa and Syzygium aromaticum oils as an effective alternative to synthetic antimicrobial agents, contributing to advancements in natural medicine.
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Praful Kumar
Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi-834010, Jharkhand, India
Asif Raza
Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi-834010, Jharkhand, India
Rajnish Kumar Rana
Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi-834010, Jharkhand, India
Satyam Prasad
Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi-834010, Jharkhand, India
Avinash Kumar Ray
Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi-834010, Jharkhand, India
Syed Mohammad Abdullah
Department of Pharmaceutical Sciences, Jharkhand Rai University, Ranchi-834010, Jharkhand, India