EFFICIENCY AND SAFETY OF 10% MINOXIDIL IN THE TREATMENT OF ALOPECIA AREATA: A RANDOMISED CONTROLLED TRIAL
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Keywords
Alopecia areata, minoxidil 10%, hair regrowth, autoimmune, SALT rating, dermatology.
Abstract
Background: Alopecia areata (AA) is a chronic autoimmune form of disease characterized by non-scarring hair loss. Topical minoxidil is commonly used in 2% and 5% concentrations, but limited proof exists of the efficacy and protection of 10% minoxidil in treating AA.
Objective: To evaluate the therapeutic efficacy as well as safety profile of 10% topical minoxidil compared to 5% minoxidil in various patients with mild to moderate alopecia areata.
Methods: A double-blind, randomised controlled trial was conducted involving one hundred twenty sufferers identified with patchy alopecia areata. Patients have been randomly assigned to get hold of either 10% or 5 % minoxidil topical answer two times each day for twenty-four weeks. Efficacy was assessed using the Severity of Alopecia Tool (SALT) rating, photographic assessment, and patient delight scale. Safety was monitored via detrimental occasion reporting and scalp assessments.
Results: Patients handled with 10% minoxidil confirmed a statistically enormous greater imply discount in SALT score (63.2% ± nine.1%) compared to the 5% organization (41.6% ± 11.5%, p < zero.01). Mild negative outcomes, consisting of scalp inflammation and erythema, were extra frequent inside the 10% group however had been self-limited.
Conclusion: 10% topical minoxidil demonstrates advanced efficacy in comparison to five% in selling hair regrowth in alopecia areata, with an appropriate safety profile. Further long-time period research is warranted.
References
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Dr. Karupalli Leslie Vasantha
House Surgeon, Konaseema Institute of Medical Sciences and Research Foundation