EVALUATION OF THE CONCORDANCE OF SERUM HER 2/NEU LEVELS WITH IMMUNOHISTOCHEMISTRY IN TUMOUR TISSUE
Main Article Content
Keywords
Serum HER 2/neu levels, immunohistochemistry, tumour tissue
Abstract
Background: Breast cancer is the second most common cancer in the world and it is the most frequent cancer among women with overall estimated 1.67 million new cancer cases diagnosed in 2012.
Objective: To evaluate concordance of serum HER-2/neu with immunohistochemistry in tumour tissue.
Methods: This present study included 56 patient suspected cases of malignancy of breast received in Department of Surgery and Department of Pathology in Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh during the period of May 2014 to September 2016.
Result: Most cases were in the stage 2 (50%, 25 cases), followed by46% (23 cases) in the stage 3 and 4% in the stage 1 (2 cases). The correlation between serum HER -2 /neu and age of the patient and mentural status was found to be non significant. (P = 0.864, NS) In the present study, there was also significant correlation between serum HER-2/neu and cytological grading, done by Robinson cytological grading system..(P<0.05,S) There were 69.6 %of serum HER-2/neu positive cases in stage3 as compared to 40 % in stage 2 and no casein stage 1. The correlation between serum HER-2 /neu and tumour stagewas found to be significant. (P < 0.05, S)
Conclusion: Serum HER -2/neu can be used as complimentary method besides tissue methods as it has advantages of being non invasive and provide real time assessment of HER -2/ neu level.
References
2. Potter CR, van Doele S, van de Vijver MJ, Pauwels C, Maertens G, De Boever J, et al. The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues. Histopathology 1989;15:351 – 62.
3. Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER2/neu oncogene. Science 1987; 235: 177–182.
4. Bramwell VH, Doig GS, Tuck AB, et al. Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer. Breast Cancer Res Treat 2009;114(3):503-11.
5. Disis ML, Gralow JR, Bernhard H, Hand SL, Rubin WD, Cheever MA. Peptide based but not whole protein vaccines elicit immunity to HER2/neu, oncogenic self protein. J Immunol 1996;156(9):3151e8.
6. Harris l, Fritsche H, Mennel R, Norton L, Ravdin P, Taube S, et al. Recommendations for the use of tumor markers in breastcancer. J Clin Oncol 2007; 25:5287 – 312.
7. Liu PC, Liu X, Li Y, Covington M, Wynn R, Huber R, et al. Identifi cation of ADAM10 as a major source of HER-2 ectodomainsheddase activity in HER-2 overexpressing breast cancer cells. Cancer Biol Ther 2006; 5:657 – 64.
8. Ludovini V, Gori S, Colozza M, Pistola L, Rulli E, Floriani I, et al. Evaluation of serum HER-2 extracellular domain in early breast cancer patients: correlation with clinicopathological parameters and survival. Ann Oncol 2008; 19:883 – 90.
9. Imoto S, Kitoh T, Hasebe T. Serum c-erbB2 levels in monitoringof operable breast cancer patients. Jpn J Clin Oncol 1999; 29:336 – 9
10. Farzadnia M, Meibodi NT, Shandiz FH, Mahmoudi M, Bahar MM, Memar B, Amoian S, et al . Evaluation of HER2/neu oncoprotein in serum and tissue samples of women with breast cancer: correlation with clinicopathological parameters. The Breast. 2010 ;19(6):489-, 92.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Islam Barkatullah Khan
Assistant Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, UP, India
Aseeb Ur Rehman
Assistant Professor, Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, UP, India
Arif Rasul
Assistant Professor, Department of General Surgery, Venkateswara Institute of Medical Sciences, Gajraula, UP, India
Mohsin Aijaz
Assistant Professor, Department of Pathology, Para Medical College, Faculty of Medicine, AMU, Aligarh, UP, India