VITAMIN D DEFICIENCY IN PATIENTS WITH CHRONIC LIVER DISEASE: A SINGLE CENTRE CROSS SECTIONAL STUDY
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Keywords
vitamin D, Deficiency, Chronic Liver Disease.
Abstract
Background: Chronic liver disease is a medical disorder characterized by a lack of certain nutrients. Those with more severe forms of this disease are more likely to have vitamin D deficiency.
Objective: The aim of the study was to determine the vitamin D Deficiency in Patients with Chronic Liver Disease.
Methodology: This cross-sectional study was carried out at Department of Medicine Mekran Medical College Turbat from January 2023 to June 2023 after taking permission from the ethical committee of the institute. A total of 143 chronic liver diseases individuals of both genders and different age groups (20 to 80 years) were included. Three groups of CLD patients were created using Child-Pugh scores. Using medical records, demographic information such as age, gender, Child-Pugh Class, frequency of CLD, and primary cause of CLD were recorded. The data was analyzed using the statistical application IBM SPSS 22.
Results: There were 143 individuals participating in this research. Thirty individuals (20.9%) had both Class A and Class B of Child-Pugh chronic liver disease, whereas 84 of them (58.7%) had Class C. CLD was most often caused by HCV in 81 cases (56.64%), followed by HBV in 32 cases (22.37%), HBV+HCV in 11 cases (7.69%), Primary Biliary Cirrhosis in 5 cases (3.49%), hemochromatosis, NAFLD, Wilson, or no underlying etiology in 14 cases (9.79%). A total of 96 individuals (67.13%) were vitamin D deficient. There was no relationship between age and vitamin deficiency in this research (p = 0.818). Vitamin D deficiency was associated with gender (p = 0.025).
Conclusion: From the current study we concluded that Vitamin D was deficient in the majority (67.13%) of Chronic liver diseases participants and mostly female and participants with severe fibrosis had vitamin D deficiency.
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Zafar Abdul Nabi
Assistant Professor of Medicine, Head of the Department of Medicine Mekran Medical College Turbat,
Faroz Khan
Assistant Professor of Medicine Mekran Medical College Turbat
Sassi Manzoor Hassan
Assistant Professor of Medicine Mekran Medical College Turbat
Abdul Wahid
Senior Registrar Jhalawan Medical College Khuzdar
Waqar Azeem Taj
Assistant Professor Gastroenterology Mekran Medical College Turbat
Abdul Bari Baloch
Assistant professor medicine Jhalawan Medical College Khuzdar