ANTITUMOR ACTIVITY OF 6-HETERO ARYL-5-HEXENE-2, 4-DIONES AND THEIR METAL COMPLEXES AGAINST DALTON’S ASCITIC LYMPHOMA IN MICE
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Keywords
ML2 stoichiometry; IR spectra; 1 H NMR; Mass; Complexation; Alanine amino Transferase; Alkaline Phosphatase;Aspartate amino Transferase
Abstract
A series of 6-Hetero aryl-5-hexene-2, 4-diones (1a-c) and their Cu (II) complexes (1d-f) of ML2 stoichiometry were synthesized by condensation of heterocyclic aldehydes with acetyl acetone through boric anhydride mediated mechanism. Boric anhydride act by blocking the medial methylene group of acetyl acetone and provides a new pathway other than facile Knoevenagel condensation. All the final structures were assigned on the basis of IR, 1H NMR and mass spectra analysis. Acute toxicity studies were performed initially in order to determine the safety of titled derivatives and the ED50 value was calculated 30 mg/kg. All the derivatives were screened for antitumor activity against Dalton’s Ascitic Lymphoma in mice. All the new candidates at a dose of 30mg/kg showed a good antitumor activity against DLA bearing mice when compared to the standard 5-fluoro uracil.
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K.L. Krishnakumar
Department of Chemistry, Karuna College of Pharmacy, Palakkad, Kerala 679533, India
Manju R
Department of Chemistry, Karuna College of Pharmacy, Palakkad, Kerala-679533, India