ROLE OF INFLAMMATORY MARKERS IN CORONARY ARTERY DISEASE
Main Article Content
Keywords
Coronary artery disease (CAD), Inflammatory markers, High-sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Tumour necrosis factor-alpha (TNF-α), Fibrinogen, Cardiovascular risk prediction, Biomarkers
Abstract
Aim
The aim of this article is to explore the role of inflammatory markers in the prediction and early detection of coronary artery disease (CAD), and to assess their potential use as predictive tools in clinical practice for improving early diagnosis and cardiovascular risk assessment.
Methods
A cross-sectional observational study was conducted on 50 participants, including 30 patients with angiographically confirmed coronary artery disease (CAD) and 20 age- and sex-matched controls without CAD. Blood samples were analyzed for inflammatory markers: high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and fibrinogen, using standard ELISA techniques. Statistical analysis was performed using SPSS version 25, with significance set at p < 0.05.
Results
Inflammatory marker levels were significantly higher in the CAD group compared to controls. The mean hs-CRP level in CAD patients was 4.8 ± 1.6 mg/L versus 2.1 ± 1.0 mg/L in controls (p < 0.001). IL-6, TNF-α, and fibrinogen were also elevated in CAD patients (all p < 0.01). A positive correlation was found between these markers and the severity of coronary artery disease.
Conclusion
The study confirms that inflammatory markers-particularly hs-CRP, IL-6, TNF-α, and fibrinogen-are significantly associated with the presence and severity of CAD. These findings suggest that inflammatory biomarkers may serve as valuable tools for risk assessment and early detection of coronary artery disease.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Praveen Kumar H.
Associate Professor, Department of General Medicine, BGS MCH Medical College, Nagarur, Bengaluru, Karnataka, India.
Dr. Saqlain N.M.
Assistant Professor, Department of General Medicine, BGS MCH Medical College, Nagarur, Bengaluru, Karnataka, India.
Dr. Gouthami D.
Assistant Professor, Department of General Medicine, BGS MCH Medical College, Nagarur, Bengaluru, Karnataka, India.
Dr. Gireesh
Professor &HOD, Department of General Medicine, BGS MCH Medical College, Nagarur, Bengaluru, Karnataka, India.