ASSOCIATION BETWEEN TSH AND SERUM CREATININE IN EUTHYROID AND HYPOTHYROID DURING PREGNANCY

Abstract

Introduction: One of the most common endocrine disorders identified during pregnancy is thyroid illness. Poor results for both the mother and the foetus have been associated with it. Abortion, preeclampsia, abruptio placenta, early labour, and foetal problems like prematurity, low birth weight, stillbirth, and perinatal mortality are the most frequent obstetric outcomes linked to thyroid disorders. A clinical syndrome known as hypothyroidism is brought on by a thyroid hormone shortage, which causes metabolic processes to generally slow down. In the general population, it is a frequent metabolic condition. After diabetes during pregnancy, thyroid illness is the second most prevalent endocrine condition. Pregnant women's physiology is significantly challenged by thyroid dysfunction, which also has important ramifications for both the mother and the foetus.

Aim and Objectives: To study the Serum Creatinine level in Euthyroid and Hypothyroid cases in pregnant women and to assess the correlation of serum creatinine with TSH.

Material and methods: This was a 12-month comparative cross-sectional study carried out from December 2023 to December 2024 at a tertiary medical centre,  Department of Obstetrics and Gynaecology .Out of the 72 participants in the trial, 60 were enrolled; the remaining 10 patients were receiving haemodialysis and were not included in the study. Two individuals were excluded because they were not followed up with. comprising 30 newly diagnosed hypothyroid patients (cases) between the ages of 20 and 40, 30 sex-matched euthyroid people, and 30 healthy controls free of any illnesses. The Cobas e411 electro-chemiluminescence method was used to measure TSH. The Modified Jaffe's method was used to measure the levels of serum creatinine.

Results: Thirty hypothyroid patients and thirty controls were among the 60 participants in the current investigation. The age group of 25–29 years old had the highest number of cases and controls (n = 26), followed by the 30–40 year old age group and the age group of 35–40 years old (n = 3).When compared to controls, it was shown that subclinical and hypothyroidism cases had significantly higher serum levels of creatinine and TSH. There was higher mean serum TSH in controls as compared to cases, and the difference among both the groups was significant and mean serum creatinine of cases was 0.82 ± 0.45, and in controls it was 0.53 ± 0.18, there being less mean serum creatinine in controls as compared to cases and the difference between both the groups being significant. There was a significant positive correlation with TSH and serum creatinine in hypothyroid cases.

Conclusion: The evaluation of the biochemical parameters (creatinine, TSH) in the current study showed that they were significant markers and that the development, monitoring, and treatment of pregnant women with hypothyroidism depended heavily on their aberrant values.