STUDY OF ANTIMICROBIAL PROPHYLAXIS, PRESCRIPTION PATTERN AND ASSOCIATED ADVERSE DRUG REACTIONS PROFILE AMONG PATIENTS UNDERGOING FOR CESAREAN SECTION IN OBSTETRICS AND GYNECOLOGY DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL
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Keywords
Prescription pattern, Adverse drug reaction, Antimicrobials prophylaxis, Cesarean Section
Abstract
Introduction: Caesarean section (C-section) procedures are becoming increasingly common worldwide. Preoperative strategies include administering prophylactic antibiotics within an hour before surgery, optimizing maternal health by treating infections during pregnancy, and ensuring proper antiseptic preparation of the surgical site. This study is planned with aims to evaluate the prescription pattern and adverse drug reaction associated with antimicrobial prophylaxis for Caesarean section.
Materials: This prospective observational study was conducted among 200 patients who visited and underwent cesarean section in department of Obstetrics and Gynaecology department at G.S.V.M. Medical College, Kanpur.
Results: All 200 preoperative prescriptions included exactly two drugs, resulting in an average of two drugs per prescription. The study observed 100% antibiotic usage across all phases. In the preoperative phase, third-generation cephalosporins (ceftriaxone) and nitroimidazoles (metronidazole) were each prescribed in 50% of cases. On postoperative day 1, aminoglycosides (gentamicin ), piperacillin+ tazobactam were added in 9.99% of cases, and by day 5, penicillin-class antibiotics with beta-lactamase inhibitors (amoxicillin-clavulanic acid) were introduced in 12.48% of cases.
Conclusions: These findings highlight the need for rational antibiotic use, reduced polypharmacy, increased generic prescribing, and stronger antibiotic stewardship to minimize ADRs, and improve patient safety in Caesarean section management.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Geeta Singh Rana
Post Graduate, Department of Pharmacology, GSVM Medical College, Kanpur (UP)
Dr. Virendra Kushwaha
DCH, MD(Pharmacology), Professor & Head, GSVM Medical College, Kanpur (UP),
Dr. Pooja Agrawal
Professor, Department of Pharmacology, GSVM Medical College, Kanpur (UP)
Dr. Renu Gupta
Professor & Head, Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur (UP)
Dr. Amit Kumar
Associate Professor, Department of Pharmacology, Govt. Medical College, Jalaun (UP)
Dr. Himanshu Sharma
Assistant Professor, Department of Pharmacology, GSVM Medical College, Kanpur (UP)