COMPARATIVE STUDY OF THE EFFICACY AND SAFETY OF DIFFERENT OVULATION INDUCTION PROTOCOLS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME IN PESHAWAR
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Keywords
Polycystic Ovary Syndrome (PCOS), Ovulation Induction, Clomiphene Citrate, Letrozole, Metformin, Infertility, Pregnancy Rate, Reproductive Health, Insulin Resistance, Anovulation.
Abstract
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine condition that frequently results in anovulatory infertility in women of reproductive age. This research evaluates the effectiveness and safety of various ovulation induction techniques in women with PCOS in Peshawar. Fifty individuals were randomly allocated to four groups: Group A (Clomiphene Citrate), Group B (Letrozole), Group C (Clomiphene Citrate + Metformin), and Group D (Letrozole + Metformin). The principal outcomes assessed were ovulation rate, pregnancy rate, and live birth rate, whereas secondary goals encompassed side effects and patient satisfaction. Group D (Letrozole + Metformin) demonstrated the greatest ovulation rate (82%) and pregnancy rate (65%), followed by Group B (Letrozole) with rates of 78% and 60%, respectively. Groups A and C exhibited comparable results, with ovulation rates of 70% and pregnancy rates of 50%. Adverse effects were negligible across all groups, with no significant disparities. Patient satisfaction reached its zenith in Group D. This study indicates that the combination of Letrozole and Metformin yields enhanced results in ovulation induction for women with PCOS in Peshawar.
References
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Dr. Mehtab shah
Ex-Trainee Medical Officer, Department of Gynecology, Lady Reading Teaching Hospital, Peshawar.