EFFICACY OF PROBIOTICS IN REDUCING ANTIBIOTIC-ASSOCIATED DIARRHEA IN CHILDREN
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Keywords
Probiotics, antibiotic-associated diarrhea, children, prevention, gut health
Abstract
Objectives: The objective is to identify the optimal probiotic strains and dosage schedules and to comprehensively evaluate the impact of probiotics in reducing the frequency, severity, and duration of antibiotic-associated diarrhea (AAD) in children.
Materials and Methods: At a tertiary care hospital in Islamabad, Pakistan, 200 children between the ages of 1 and 12 who had taken antibiotics participated in the current study, which was a randomized placebo-controlled trial. Two groups of participants were created, one for the probiotic and one for the placebo. While the placebo group received the placebo in the form of empty sachets, the probiotic group received the multispecies probiotics as a supplement. After gathering data on AAD incidence, prevalence, and severity, statistical analysis was performed.
Results: The children in the placebo group had a high risk of AAD (35%, p<0.01), while the children in the probiotic group had a reduced rate of 15%. Additionally, there was a substantial decrease in the overall duration of AAD from 4.8 days in the placebo group to 2.5 days in the probiotic group (p<0.05). Additionally, probiotic supplementation decreased the severity of diarrhea and demonstrated an excellent safety profile.
Conclusion: Because probiotics have fewer adverse effects, the study demonstrated that they are useful in both preventing and treating AAD in children.
References
2- Maity, C. and Gupta, A.K., 2021. Therapeutic efficacy of probiotic Alkalihalobacillus clausii 088AE in antibiotic-associated diarrhea: A randomized controlled trial. Heliyon, 7(9).
3- Liao, W., Chen, C., Wen, T. and Zhao, Q., 2021. Probiotics for the prevention of antibiotic-associated diarrhea in adults: a meta-analysis of randomized placebo-controlled trials. Journal of Clinical Gastroenterology, 55(6), pp.469-480.
4- Goodman, C., Keating, G., Georgousopoulou, E., Hespe, C. and Levett, K., 2021. Probiotics for the prevention of antibiotic-associated diarrhea: a systematic review and meta-analysis. BMJ open, 11(8), p.e043054.
5- Parmar, D.J., 2024. The Effects of Probiotic Supplementation on Antibiotic-Associated Diarrhea in Pediatric Patients a Randomized, Placebo-Controlled Trial. European Journal of Cardiovascular Medicine, 14(1).
6- Shyoran, R., Kaur, A., Bharat, P. and Pathania, R., 2024. Effect of probiotic yogurt on antibiotic-associated diarrhea among pediatric patients randomized controlled trial. Journal of Education and Health Promotion, 13(1), p.317.
7- Rajkumar, C., Wilks, M., Islam, J., Ali, K., Raftery, J., Davies, K.A., Timeyin, J., Cheek, E., Cohen, J., Wright, J.U.L.I.E.T. and Natarajan, U., 2020. Do probiotics prevent antibiotic-associated diarrhea? Results of a multicentre randomized placebo-controlled trial. Journal of Hospital Infection, 105(2), pp.280-288.
8- De Castro, J.A., Kesavelu, D., Lahiri, K.R., Chaijitraruch, N., Chongsrisawat, V., Jog, P.P., Liaw, Y.H., Nguyen, G.K., Nguyen, T.V.H., Pai, U.A. and Phan, H.N.D., 2020. Recommendations for the adjuvant use of the poly-antibiotic–resistant probiotic Bacillus clausii (O/C, SIN, N/R, T) in acute, chronic, and antibiotic-associated diarrhea in children: consensus from Asian experts. Tropical diseases, travel medicine and vaccines, 6, pp.1-15.
9- Zhang, L., Zeng, X., Guo, D., Zou, Y., Gan, H. and Huang, X., 2022. Early use of probiotics might prevent antibiotic-associated diarrhea in elderly (> 65 years): a systematic review and meta-analysis. BMC geriatrics, 22(1), p.562.
10- Ma, Y., Yang, J.Y., Peng, X., Xiao, K.Y., Xu, Q. and Wang, C., 2020. Which probiotic has the best effect on preventing Clostridium difficile‐associated diarrhea? A systematic review and network meta‐analysis. Journal of Digestive Diseases, 21(2), pp.69-80.
11- Fadin, L., de Oliveira Vieira, K.C., Toledo, A.C.C.G., Da Silva, A.K.F., Pereira, V.C. and Winkelstroter, L.K., 2023. Probiotics in the Management of Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-analysis of Randomized and Controlled Trials. Topics in Clinical Nutrition, 38(3), pp.211-223.
12- Łukasik, J., Guo, Q., Boulos, L., Szajewska, H. and Johnston, B.C., 2020. Probiotics for the prevention of antibiotic-associated adverse events in children—A scoping review to inform the development of a core outcome set. PLoS One, 15(5), p.e0228824.
13- Ferguson, J.R. and Taylor, K., 2022. Probiotics for Antibiotic-Associated Diarrhea: What, When, and How Long? International Journal of Clinical Medicine, 13(12), pp.571-583.
14- Doar, N.W. and Samuthiram, S.D., 2023. Qualitative analysis of the efficacy of probiotic strains in the prevention of antibiotic-associated diarrhea. Cureus, 15(6).
15- Schnadower, D., O'Connell, K.J., VanBuren, J.M., Vance, C., Tarr, P.I., Schuh, S., Hurley, K., Rogers, A.J., Poonai, N., Roskind, C.G. and Bhatt, S.R., 2021. Association between diarrhea duration and severity and probiotic efficacy in children with acute gastroenteritis. Official journal of the American College of Gastroenterology| ACG, 116(7), pp.1523-1532.
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Muhammad Abbas
Associate Professor of Pediatrics Medicine, Rahber Medical and Dental College Lahore, Pakistan
Muhammad Fareeduddin
Consultant Pediatrician, Indus Hospital, Karachi, Pakistan
Muhammad Imran
Consultant Paediatrician, Department of Paediatrics, DHQ Hospital Narowal, Punjab, Pakistan
Dr. Riffat Farrukh
Assistant Professor, Department of paediatrics, Abbasi shaheed hospital Karachi.
Email: riffatfarrukh15@gmail.com
Tufail Ahmed Soomro
Assistant Professor, GMMMC Hospital Sukkur, Pakistan
Poonam Kataria
Senior Registrar, Bolan Medical Complex Hospital Quetta, Pakistan