A study on the antimicrobial susceptibility pattern of Nitrofurantoin and Fosfomycin against gram negative uropathogens in a teaching hospital of South Bengal.
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Keywords
Urinary tract infections, Antibiotic resistance, Fosfomycin
Abstract
INTRODUCTION- Urinary tract infections (UTIs) are the most common bacterial infection which can affect all age groups. They lead to large proportion of antibiotic consumption contributing to development of antibiotic resistance .UTIs caused by multidrug resistant (MDR) pathogens have limited treatment options. Fosfomycin (FO) and Nitrofurantoin(NIT) are broad-spectrum oral antibiotics with high urine concentration and bactericidal activity against a wide range of bacteria.Their use in complicated UTI has caused emergence of increased antibiotic resistance for these two urinary specific antibiotics
AIM-
- To identify the sensitivity pattern of gram negative uro-pathogens to Nitrofurantoin and Fosfomycin
- To compare the sensitivity and resistance patterns of Nitrofurantoin and Fosfomycin in different age groups of our study population
MATERIALS AND METHODS- Isolation and identification of microorganisms from aseptically collected urine samples of UTI patients were done by standard microbiological procedures and tests.. Antibiotic susceptibility testing was done by Kirby-Bauer’s disc diffusion method on Muller-Hinton agar and results interpreted according to CLSI guidelines 2024.
RESULTS- Escherichia coli was the most common gram negative pathogen detected (60.22%)followed by Klebsiella pneumoniae (25.97%).Sensitivity to Fosfomycin was high among all the gram negative pathogens but sensitivity to Nitrofurantoin was found to be lower in comparison to Fosfomycin sensitivity.
CONCLUSION- Both Nitrofurantoin and Fosfomycin are urine specific antibiotics which should be used with proper prescription and caution following the principles of antimicrobial stewardship protocol so that emergence of antibiotic resistance strains can be prevented.
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Dr Sayani Bose
Senior Resident,Department of Microbiology, Tamralipto Government Medical College and Hospital,Tamluk,Purba Medinipur,West Bengal.,INDIA
Dr Feradica D Laloo
Senior Resident,Department of Microbiology, Jalpaiguri Government Medical College and Hospital,Jalpaiguri,West Bengal,INDIA
Dr Christopher Rolawmum Infimate
Junior Resident 3rd yr, Department of General Medicine, Nilratan Sircar Medical College and Hospital,Kolkata, INDIA
Dr Anirban Bhaduri
Associate Professor,Department of Microbiology, Tamralipto Government Medical College and Hospital,Tamluk,Purba Medinipur,West Bengal.,INDIA
